Anti-inflammatory and antitumoural effects of Uncaria guianensis bark

Urdanibia, Izaskun; Michelangeli, Fabián A.; Ruiz, Marie Christine; Milano, Balentina; Taylor, Peter

doi:10.1016/j.jep.2013.10.055

Cited by 13 publications

(12 citation statements)

References 34 publications

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“…as a specific example. Although both anti-inflammatory and anticancer activities have been reported for this plant (Heitzman et al, 2005), results from our laboratory suggest that the antitumoural activity of Uncaria may be due to a great degree to its anti-inflammatory properties (Caballero et al, 2005;Fazio et al, 2008;Urdanibia et al, 2013). Although cytotoxic compounds have been identified, we do not believe that they are present at a high enough concentration in Uncaria extracts to explain the anticancer effect.…”

Section: Relationship Between Inflammation and Cancermentioning

confidence: 68%

The search for plants with anticancer activity: Pitfalls at the early stages

Taylor

Colman

Bajoon

2014

Journal of Ethnopharmacology

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Section: Relationship Between Inflammation and Cancermentioning

confidence: 68%

The search for plants with anticancer activity: Pitfalls at the early stages

Taylor

Colman

Bajoon

2014

Journal of Ethnopharmacology

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“…Accumulating evidence indicates that NO and PGE 2 are important mediators of inflammation, such as autoimmune diseases and neurodegenerative disease [25][26][27][28][29][30]. The generation of excessive NO and PGE2 in response to various inflammatory stimuli contributes to the development of chronic inflammatory diseases [31][32][33][34]. For these reasons, the suppression of NO production may possibly be a promising strategy against inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages

Lei¹,

Zhao²,

Zhang³

et al. 2016

ABBS

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Inflammation is a response of body tissues to injury and infection. Compounds that can inhibit inflammation have been shown to have potential therapeutic clinical application. Gambogenic acid (GEA) has potent antitumor and anti-inflammatory activities. Herein, the molecular mechanisms of GEA's anti-inflammatory effect were investigated in lipopolysaccharide (LPS)-stimulated macrophage cells. The results showed that pretreatment with GEA could markedly inhibit interleukin (IL)-1α, IL-1β, tumor necrosis factor-α, IFN-β, IL-12b, and IL-23a production in a dose-dependent manner in LPS-induced model. Furthermore, this drug significantly reduced the release of nitric oxide (NO), and impaired the protein level of inducible NO synthase and the cyclooxygenase 2. The finding also showed that the effect of GEA may be related to the suppression of the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathway. These results indicate that GEA could suppress LPS-simulated inflammatory response partially by attenuating NO synthesis and NF-κB and MAPK activation, suggesting that it may become a potent therapeutic agent for the treatment of inflammatory diseases.

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“…In addition, Uncaria preparations may possess immunomodulatory and chemopreventive properties besides direct cytotoxic activity. The former assumption is supported by the involvement of anti-inflammatory processes rather than cytotoxic events in the antitumor activity of a hydroethanolic U. guianensis stembark extract in 4 T1 mammary tumor-bearing BALB/c mice [161]. The latter supposition stems from the changes in expression patterns of critical proto-oncogenes and tumor suppressor genes in DMBA-treated CBA/Ca mice following administration of Claw of Dragon tea (CoD™ tea), a mixture of the stembarks from U. guianensis, U. tomentosa, and the trumpet-tree Tabebuia avellanedae Lorentz ex Griseb.…”

Section: Loranthaceae-phthirusa Stelis (L) Kuijtmentioning

confidence: 92%

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

Mans¹,

Irving²

2019

Pharmacognosy - Medicinal Plants

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Despite much progress in our understanding of the essence of cancer, remarkable advances in methods for early diagnosis, the expanding array of antineoplastic drugs and treatment modalities, as well as important refinements in their use, this disease is among the leading causes of morbidity and mortality in many parts of the world. In fact, the next decade is anticipated to bring over 20 million new cases per year globally, about half of whom will die from their disease. This indicates a need for better strategies to deal with cancer. One way to go forward is to draw lessons from ancient ethnopharmacological wisdom and to evaluate the plant biodiversity for compounds with potential antineoplastic activity. This approach has already yielded many breakthrough cytotoxic drugs such as vincristine, etoposide, paclitaxel, and irinotecan. The Republic of Suriname (South America), renowned for its pristine and highly biodiverse rain forests as well as its ethnic, cultural, and ethnopharmacological diversity, could also contribute to these developments. This chapter addresses the cancer problem throughout the world and in Suriname, extensively deals with nine plants used for treating cancer in the country, and concludes with their prospects in anticancer drug discovery and development programs.

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Anti-inflammatory and antitumoural effects of Uncaria guianensis bark

Cited by 13 publications

References 34 publications

The search for plants with anticancer activity: Pitfalls at the early stages

The search for plants with anticancer activity: Pitfalls at the early stages

Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

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Anti-inflammatory and antitumoural effects of Uncaria guianensis bark

Cited by 13 publications

References 34 publications

The search for plants with anticancer activity: Pitfalls at the early stages

The search for plants with anticancer activity: Pitfalls at the early stages

Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-&kappa;B and MAPK in macrophages

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

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Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages