Anti-inflammatory and antipyretic properties of Kang 601 heji, a traditional Chinese oral liquid dosage form

Alolga, Raphael N.; Amadi, Sarah Wambui; Onoja, Vitus; Assanhou, Assogba Gabin; Muyaba, Moses; Kassim, Said Abasse

doi:10.1016/j.apjtb.2015.08.001

Cited by 6 publications

(3 citation statements)

References 28 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animals intraperitoneally treated with NST promoted a significant reduction of nitrite concentrations at doses of 100 and 200 mg/kg. Interestingly, extraction fractions obtained from Alstonia scholaris L. containing alkaloids such as picrinine, valesamine, and escolaricin, which contain the indolic nucleus in their structures, also displayed the anti-inflammatory effect by inhibition of NO and PGE 2 biosyntheses [41].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents

NETO

Cunha

Nunes

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Purpose. To investigate the anti-inflammatory and antioxidant activities of N-salicyloyltryptamine (NST) in experimental models of carrageenan (Cg)-induced peritonitis in mice, and evaluation of the effects of NST on Cg-induced joint disability in rats. Methods. Female Swiss mice were submitted to Cg-induced peritonitis in mice or Cg-induced joint disability in rats after intraperitoneal injection of NST (100 or 200 mg/kg). Total leukocyte count, total protein concentration, myeloperoxidase (MPO) and catalase (CAT) activities, and nitrite ( NO 2 − ) and thiobarbituric acid reactive species (TBARS) levels were determined. Results. NST significantly decrease the migration of leukocytes to peritoneal exudate. Cg induces inflammatory responses mediated by expression of reactive oxygen species (ROS). The results further showed that NST significantly decreased MPO and CAT activities, as well as reduced NO 2 − and TBARS levels, compared with the vehicle group. Animals treated with NST significantly reduced paw elevation time (PET) on the first hour after induction of joint injury, and this effect was sustained throughout the analysis. Conclusion. NST presented anti-inflammatory and antioxidant effects in experimental models of carrageenan-induced peritonitis and joint disability in mice and rats, respectively, which may be related to the modulation of neutrophils migration as well as the involvement of antioxidant mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents

NETO

Cunha

Nunes

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…These results suggested that the Galla Chinensis and indomethacin could slow down the inflammatory symptoms and had a remarkable inhibitory effect on the release of PGE 2 . Early results showed that IL-10 effectively inhibited the expression of cytokines and had an important role in stimulating immune and inflammatory responses [ 33 ]. Therefore, the level of IL-10 is also important for inflammation diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract ofGalla Chinensis In VivoModels

Sun

Song

Jia

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Aim Pain and inflammation are associated with many diseases in humans and animals. Galla Chinensis, a traditional Chinese medicine, has a variety of pharmacological properties. The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models. Method The analgesic activities were evaluated by hot-plate and writhing tests. The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests. The contents of cytokines (NO, iNOS, PGE2, and IL-10) in serum of rats in paw edema test were inspected by ELISA assays. Results In the hot-plate test, Galla Chinensis could significantly extend pain threshold when compared to control group. The inhibitory rates of writhes ranged from 36.62% to 68.57% in Galla Chinensis-treated mice. Treatment with Galla Chinensis (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; P < 0.01). Galla Chinensis (1 g/kg) had significant (P < 0.05) anti-inflammatory activity in capillary permeability test (29.04%). In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% (P < 0.01) at 1 h and 2 h after administration of Galla Chinensis (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced. Conclusion These results suggest that Galla Chinensis has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain.

show abstract

“…It triggers the hypothalamus to increase body temperature. To treat fever, paracetamol and non-steroidal antiinflammatory drugs are prescribed 21,22 . NSAIDs inhibit cyclooxygenase 2 (COX-2) to reduce body temperature by inhibiting prostaglandin E2 biosynthesis 23 .…”

Section: Antipyretic Activitymentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Background: Fever is a part of a complex biological response due to pathogens, bacterial infection, damaged cells, drugs, toxins, etc. Fever is currently treated by NSAIDs. Unfortunately, NSAIDs damage the liver and kidney, inhibit COX-1, which affects the digestive system, and increase the risk of a blood clot. Therefore, the developments of potent antipyretic drugs from medicinal herbal plants are now under consideration. Polyherbal formulations (PHFs) was become resurgent due to the demand and consumption of herbal drugs. The present research aims to evaluate the antipyretic screening activity of PHFs in albino Wistar rats. Material methods: Different PHFs combinations were formulated using hydro-alcoholic extracts and explored the antipyretic activity of PHFs in albino Wistar rats. Male albino Wistar rats weighing 100-150g were selected and grouped among normal control, standard (Paracetamol; 150mg/kg) and treatment groups (PHF; 100 mg/kg, PHF; 300 mg/kg and PHF; 600 mg/kg) respectively. To check the safety parameters of PHFs extract, Hematological and biochemical tests were also performed. Results: PHFs (100mg/kg, 300mg/kg and 600mg/kg) shows antipyretic effect against brewer's yeast induced pyrexia in rats. It is noted that the % inhibition is 57.59 % in standard PCM, 43.39%in 100mg/kg, 42.68% in 300mg/kg and 42.66% in 600mg/kg dose. Discussion and Conclusions: The extract of PHFs has shown good antipyretic activity in Wistar rats. The present investigation comprised of pharmacological screening of PHFs extract in lab animals. The chemical constituents of PHFs extract were identified by different qualitative chemical test, and PHFs was selected for the pharmacological screening of antipyretic activity. The PHFs (100mg/kg, 300mg/kg, and 600mg/kg) show a significantly decreased pyretic effect against brewer's yeastinduced pyrexia in rats compared to the normal group. This suggests its efficacy in preventing hyperthermia. The extract of PHF S shows important compounds such as carbohydrates, steroids, alkaloids, flavonoids, tannins, and triterpenes which may be responsible for antipyretic activity.INTRODUCTION: Antipyretic refers to the substance which is used to reduce body temperature. In 1838 salicylic acid was first discovered from glucosidesalicin. In 1853 acetylsalicylic acid was synthesized, and this drug was commercially available in 1899.

show abstract

Anti-inflammatory and antipyretic properties of Kang 601 heji, a traditional Chinese oral liquid dosage form

Cited by 6 publications

References 28 publications

Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents

Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents

Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract ofGalla Chinensis In VivoModels

Untitled

Contact Info

Product

Resources

About