Anti-inflammatory and antiproliferative diterpenoids from Plectranthus scutellarioides

Cretton, Sylvian; Saraux, Noémie; Monteillier, Aymeric; Righi, Davide; Marcourt, Laurence; Genta‐Jouve, Grégory; Wolfender, Jean‐Luc; Cuendet, Muriel; Christen, Philippe

doi:10.1016/j.phytochem.2018.06.012

Cited by 31 publications

(32 citation statements)

References 23 publications

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“…P. hadiensis acetonic extract had a growth inhibition effect on MDA-MB-231 cancer cells (IC 50 value of 25.6 µg/mL, Table 3 ). Many studies have attributed the cytotoxicity of Plectranthus extracts to the presence of royleanone-type abietane diterpenoids with known anticancer activities [ 18 , 36 ]. The abietane-type diterpenoid royleanones are a highly bioactive group of lead molecules, important for the development of new anticancer drugs [ 22 ] Given the good levels of bioactivity of P. hadiensis extract in all the cell lines tested, it was selected to identify its main bioactive component.…”

Section: Resultsmentioning

confidence: 99%

“…Phytochemical studies on some species of Plectranthus revealed the presence of a large number of diterpenes and triterpenes [ 10 , 11 ]. Isolated terpenes from Plectranthus species are reported to possess antibacterial [ 12 , 13 , 14 ], antitumoral [ 15 , 16 , 17 , 18 ], antifungal [ 12 , 19 ], insecticidal [ 20 ], and antiplasmodial [ 20 ] activities. Moreover, our group has been focused on the phytochemical study of Plectranthus species and we have reported abietane diterpenoids with diverse bioactivity [ 16 , 17 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

et al. 2021

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Plectranthus species (Lamiaceae) have been employed in traditional medicine and this is now validated by the presence of bioactive abietane-type diterpenoids. Herein, sixteen Plectranthus acetonic extracts were prepared by ultrasound-assisted extraction and their biological activity was screened. The antimicrobial activity of each extract was screened against yeasts, and Gram-positive and Gram-negative bacteria. The P. hadiensis and P. mutabilis extracts possessed significant activity against Staphylococcus aureus and Candida albicans (microdilution method). Moreover, all extracts showed antioxidant activity using the DPPH method, with P. hadiensis and P. mutabilis extracts having the highest scavenging activities. Selected by the Artemia salina model, P. hadiensis and P.ciliatus possessed low micromolar anti-proliferative activities in human colon, breast, and lung cancer cell lines. Furthermore, the most bioactive extract of P. hadiensis leaves and the known abietane diterpene, 7α-acetoxy-6β-hydroxyroyleanone isolated from this plant, were tested against the aggressive type triple negative breast cancer (MDA-MB-231S). P. hadiensis extract reduced the viability of MDA-MB-231S cancer cell line cells, showing an IC50 value of 25.6 µg/mL. The IC50 value of 7α-acetoxy-6β-hydroxyroyleanone was 5.5 µM (2.15 µg/mL), suggesting that this lead molecule is a potential starting tool for the development of anti-cancer drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

et al. 2021

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“…The diterpene quinone 6-acetylfredericone B and the two-quinone like diterpenoids coleon G and O were tested on MM-CSC and RPMI226 cells [ 176 ]. The three compounds, which were isolated from Plectranthus scutellarioides, showed IC 50 values of 17.6, 37.4, and 9.2 µM, respectively, against MM-CSC cells as well as values of 21.6, 38.4, and 8.4 µM, respectively, against RPMI8226 cells.…”

Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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A literature search on plant natural products with antimyeloma activity until the end of 2020 resulted in 92 compounds with effects on at least one human myeloma cell line. Compounds were divided in different compound classes and both their structure–activity-relationships as well as eventual correlations with the pathways described for Multiple Myeloma were discussed. Each of the major compound classes in this review (alkaloids, phenolics, terpenes) revealed interesting candidates, such as dioncophyllines, a group of naphtylisoquinoline alkaloids, which showed pronounced and selective induction of apoptosis when substituted in position 7 of the isoquinoline moiety. Interestingly, out of the phenolic compound class, two of the most noteworthy constituents belong to the relatively small subclass of xanthones, rendering this group a good starting point for possible further drug development. The class of terpenoids also provides noteworthy constituents, such as the highly oxygenated diterpenoid oridonin, which exhibited antiproliferative effects equal to those of bortezomib on RPMI8226 cells. Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-κB and proteasome chymotrypsin-like activity.

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“…Abietane-type diterpenes are abundant in nature and have various biological activities and pharmacological properties, such as antitumor (26), antiviral (27), antibacterial (28, 29), and anti-inflammatory (30). However, their antiallergic effect has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Scrodentoid A Inhibits Mast Cell–Mediated Allergic Response by Blocking the Lyn–FcεRIβ Interaction

Qian

Zhang

et al. 2019

Front. Immunol.

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Background: Mast cells are considered an attractive therapeutic target for treating allergic diseases, and the Lyn–FcεRIβ interaction is essential for mast cell activation. This study investigated the antiallergic effect of scrodentoid A (SA) on mast cells and mast cell–mediated anaphylaxis. Methods: For in vitro experiments, mast cells were treated with SA. Cell proliferation was tested using the XTT assay. The mRNA expression of various cytokines and chemokines was measured using qPCR. The levels of histamine, eicosanoids (PGD 2 , LTC 4 ), and cytokines were measured using enzyme immunoassay kits. Signaling was investigated using Western blotting and immunoprecipitation. For in vivo experiments, the antiallergic activity of SA was evaluated using two mouse models of passive anaphylaxis as passive cutaneous and systemic anaphylaxis. The mechanism was investigated through immunohistochemistry and immunofluorescence. Results: SA considerably inhibited immunoglobulin (Ig) E-mediated mast cell activation, including β-hexosaminidase release, mRNA and protein expression of various cytokines, and PGD 2 and LTC 4 release . Oral administration of SA effectively and dose-dependently suppressed mast cell–mediated passive cutaneous and systemic anaphylaxis. SA significantly attenuated the activation of Lyn, Syk, LAT, PLCγ, JNK, Erk1/2, and Ca 2+ mobilization without Fyn, Akt, and P38 activation by blocking the Lyn–FcεRIβ interaction. Conclusions: SA suppresses mast cell–mediated allergic response by blocking the Lyn–FcεRIβ interaction in vitro and in vivo . SA may be a promising therapeutic agent for allergic and other mast cell–related diseases.

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Anti-inflammatory and antiproliferative diterpenoids from Plectranthus scutellarioides

Cited by 31 publications

References 23 publications

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Scrodentoid A Inhibits Mast Cell–Mediated Allergic Response by Blocking the Lyn–FcεRIβ Interaction

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