Anti-inflammatory and antioxidative activity of anthocyanins from purple basil leaves induced by selected abiotic elicitors

Szymanowska, Urszula; Złotek, Urszula; Karaś, Monika; Baraniak, Barbara

doi:10.1016/j.foodchem.2014.09.043

Cited by 81 publications

(55 citation statements)

References 35 publications

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“…The antioxidant capacity of basil has been reported in numerous studies (Szymanowska et al, 2015), indicating that regardless of genotype, basil is a potential source of bioactive compounds with antioxidant capacity. On the other hand, the results showed that the antioxidant capacity of basil was higher with the increase of the potassium level, demonstrating this with the significant positive correlation obtained (R2= 0.951) between NK and CA in the three genotypes studied (Table 3 ).…”

Section: Resultados Y Discusiónmentioning

confidence: 98%

“…For NK factor, yields were statistically similar with the levels of 9, 11 and 13 mM, the lowest yield was 7 mM. capacidad antioxidante de albahaca se ha reportado en numerosos estudios (Szymanowska et al, 2015), lo cual indica que independientemente del genotipo, la albahaca es una fuente potencial de compuestos bioactivos con capacidad antioxidante. Por otra parte, los resultados mostraron que la capacidad antioxidante de la albahaca fue mayor con el aumento del nivel de potasio, demostrándose esto con la correlación positiva significativa obtenida (R2= 0.951) entre NK y CA en los tres genotipos estudiados (Cuadro 3).…”

Section: Resultados Y Discusiónunclassified

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Efecto del potasio en el contenido fenólico y capacidad antioxidante de Ocimum basilicum L.

Martínez¹,

Salas-Pérez²,

Soto³

et al. 2017

Remexca

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ResumenEn la última década, se han realizado numerosos esfuerzos para incrementar el contenido de compuestos fenólicos y la capacidad antioxidante de plantas que vayan directo al consumo humano, empleando para esto diversos métodos de cultivo; sin embargo, los resultados han sido discrepantes acerca de la calidad de los frutos y el rendimiento obtenido, concluyendo que el alto contenido de compuestos fenólicos y la capacidad antioxidante no ha sido garantía de alto rendimiento de los cultivos. Por lo tanto, el objetivo de este estudio fue determinar un posible aumento del contenido en compuestos fenólicos totales, capacidad antioxidante total y rendimiento de tres genotipos de albahaca (Sweet Lemon, Red Rubin y Cinnamon) producidos bajo diferentes niveles de potasio (7, 9, 11 y 13 mM). Adicionalmente, se evaluó materia seca, altura de planta y número de hojas. El trabajo se llevó a cabo en la Comarca Lagunera de Durango en el año 2014. El análisis de varianza mostró diferencias significativas (p≤ 0.001) por efecto de genotipo y nivel de potasio en casi todas las variables. Se encontró interacción en compuestos fenólicos totales, capacidad antioxidante, rendimiento y altura de la planta. También se encontró correlación (R2) (p≤ 0.05) entre el nivel de potasio y todas AbstractIn the last decade, numerous efforts have been made to increase the content of phenolic compounds and the antioxidant capacity of plants that go directly to human consumption, using for this several methods of cultivation; however, the results have been discrepant about the quality of the fruits and the yield obtained, concluding that the high content of phenolic compounds and the antioxidant capacity has not been a guarantee of high crop yields. Therefore, the objective of this study was to determine a possible increase in total phenolic compounds, total antioxidant capacity and yield of three basil genotypes (Sweet Lemon, Red Rubin and Cinnamon) produced under different levels of potassium (7,9 , 11 and 13 mM). In addition, dry matter, plant height and number of leaves were evaluated. The work was carried out in the Comarca Lagunera of Durango in the year 2014. The analysis of variance showed significant differences (p≤ 0.001) due to genotype and potassium levels in almost all variables. It was found interaction in total phenolic compounds, antioxidant capacity, yield and height of the plant. The correlation (R2) (p≤ 0.05) was also found between the potassium level and all variables. The results indicate that las variables. Los resultados indican que el control de potasio en la solución de nutrientes puede ser una opción viable para mejorar las cualidades nutracéuticas en cuanto al contenido de compuestos fenólicos totales y la capacidad antioxidante sin afectar el rendimiento de albahaca.Palabras clave: Ocimum basilicum L., antioxidants, concentración de potasio, rendimiento.

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Section: Resultados Y Discusiónmentioning

confidence: 98%

Section: Resultados Y Discusiónunclassified

Efecto del potasio en el contenido fenólico y capacidad antioxidante de Ocimum basilicum L.

Martínez¹,

Salas-Pérez²,

Soto³

et al. 2017

Remexca

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“…23) Since anthocyanin has anti-oxidant effects, 24) we first examined the radical scavenging activities of CAJY using the DPPH assay. CAJY scavenged free radicals in a concentration-dependent manner ( Fig.…”

Section: Cajy Reducesmentioning

confidence: 99%

<i>p</i>-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of <i>Solanum tuberosum</i> Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Induced RAW264.7 Macrophages

Lee

Shin

et al. 2017

Biological & Pharmaceutical Bulletin

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Previously, we first reported the identification of four p-coumaroyl anthocyanins (petanin, peonanin, malvanin, and pelanin) from the tuber epidermis of colored potato (Solanum tuberosum L. cv JAYOUNG). In this study, we investigated the anti-oxidative and anti-inflammatory effects of a mixture of peonanin, malvanin, and pelanin (10 : 3 : 3; CAJY). CAJY displayed considerable radical scavenging capacity of 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), increased mRNA levels of the catalytic and modulatory subunit of glutamate cysteine ligase, and subsequent cellular glutathione content. These increases preceded the inhibition of lipopolysaccharide (LPS)-induced intracellular reactive oxygen species (ROS) production. CAJY inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a concentration-dependent manner at the protein, mRNA, and promoter activity levels. These inhibitions caused attendant decreases in the production of prostaglandin E 2 (PGE 2 ). CAJY suppressed the production and mRNA expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Molecular data revealed that CAJY inhibited the transcriptional activity and translocation of nuclear factor κB (NF-κB) and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT3. Taken together, these results suggest that the anthocyanin mixture exerts anti-inflammatory effects in macrophages, at least in part by reducing ROS production and inactivating NF-κB and STAT 1/3. Key words anthocyanin; macrophage; antioxidant; anti-inflammatory; nuclear factor κB; signal transducer and activator of transcription Reactive oxygen species (ROS) are important in various biological processes at the levels of gene expression, protein translation, post-translational modification, and protein interactions.1) Cell-derived ROS independently or cooperatively regulate cellular signaling in response to environmental cues. 1)A sustained pro-inflammatory state characterized by excessive ROS production is the common aspect in the development, progression, and complication of obesity, infections, cardiovascular and neurodegenerative diseases, and cancer.2-4) The shift in the balance between oxidants and anti-oxidants in favor of oxidants is termed oxidative stress. This stress contributes to many pathological conditions.Aerobic organisms have integrated anti-oxidant systems, which include enzymatic and non-enzymatic antioxidants, that are usually effective in blocking harmful effects of ROS. 5)Anti-oxidant defense systems comprise glutathione (GSH) and its synthesis, phase II detoxifying enzymes, and ROS inactivating enzymes, which play key roles in protecting cells upon oxidative damage. 6) GSH effectively protects cells from various oxidative stresses caused by scavenging free radicals, suppression of lipid peroxidation, and removal of hydrogen peroxides in cells.7) Glutamate cysteine ligase (GCL) is the rate-limiting enzyme for de novo GSH synthesis and comprises a heterodimer formed of a catalytic subunit (GCLC) and a modulator...

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“…In recent years, many studies have reported that anthocyanins have strong antioxidants, which could lower the size of adipocytes and anticarcinogenic properties [1,2,3,4]. Meanwhile, it can protect the DNA from being damaged by free radicals [5] .…”

Section: Introductionmentioning

confidence: 99%

Changes in content and component of purple corn (Zea Mays L.) anthocyanin during the extraction and preparation

Wang¹,

Ma²,

Liu³

et al. 2015

Proceedings of the 2015 International Conference on Power Electronics and Energy Engineering

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Abstract-The contents of the total anthocyanin and color were detected in the purple corn at different process. The anthocyanin content at concentrating and spry drying process was decreased by 10.93%, 21.46% respectively compared to the extraction. The redness (a*) decreased significantly during the preparation process. Furthermore, the components of acylated group will decrease, whereas the unacylated group will increase during the extraction and preparation process.

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Anti-inflammatory and antioxidative activity of anthocyanins from purple basil leaves induced by selected abiotic elicitors

Cited by 81 publications

References 35 publications

Efecto del potasio en el contenido fenólico y capacidad antioxidante de Ocimum basilicum L.

Efecto del potasio en el contenido fenólico y capacidad antioxidante de Ocimum basilicum L.

<i>p</i>-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of <i>Solanum tuberosum</i> Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Induced RAW264.7 Macrophages

Changes in content and component of purple corn (Zea Mays L.) anthocyanin during the extraction and preparation

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