Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review

Abstract

Sesame oil (SO) is a supplement that has been known to have anti-inflammatory and antioxidant properties, which makes it effective for reducing atherosclerosis and the risk of cardiovascular disease. Due to the side effects of statins, the current recommended treatment for atherosclerosis and cardiovascular diseases, the idea of using dietary and nutritional supplementation has been explored. The benefits of a dietary health regime have piqued curiosity because many different cultures have reaped health benefits through the ingredients in their cooking with negligible side effects. The purpose of this literary review is to provide a broad overview of the potential benefits and risks of SO on the development of atherosclerosis and its direction toward human clinical use. Current in vivo and in vitro research has shed light on the effects of SO and its research has shown that SO can decrease low-density lipoprotein (LDL) levels while maintaining high-density lipoprotein (HDL) levels. Current limitations in recent studies include no standardized doses of SO given to subjects and unknown specific mechanisms of the different components of SO. Future studies should explore possible synergistic and adverse effects of SO when combined with current recommended pharmaceutical therapies and other adjunct treatments.

Simvastatin Does Not Affect Nitric Oxide Generation Increased by Sesame Oil in Obese Zucker Rats

“…There were no significant changes in TBARS concentration within the groups; however, decreasing trend in TBARS concentration after SO treatment in Zucker fa/fa rats was seen. In agreement with our study, antioxidant effect of sesame oil and its polyphenolic compounds were documented in atherosclerotic and diabetic conditions [ 18 , 34 ] or in hyperlipidemic patients [ 24 ]. By reducing oxidative load, sesame oil may have direct activated effect on endothelial NOS leading to increase in NO production.…”

“…Unfortunately, there are only limited data concerning the effects of sesame oil on NOS activity. Hsu and Parthasarathy [ 18 ] found that sesame oil significantly decreased lipid peroxidation but did not increase nitric oxide compared to N-acetyl cysteine. Sharma et al [ 32 ] have found an upregulation of eNOS in rats with cardiometabolic syndrome after sesamol treatment.…”

“…All of them are considered to be protective [ 13 , 14 ] acting as antioxidants, antihypertensives, anti-inflammatory, and cardioprotective substances [ 15 – 17 ]. By reducing 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity, sesamin could also potentially reduce LDL levels in a similar manner as statin drugs without side effects [ 18 ]. Similarly, different other polyphenols, also those including in the sesame, may improve vasoactivity, endothelial function, and nitric oxide (NO) production.…”

The EFFECT OF THE COMBINATION OF THE SESAME OIL AND VITAMIN E TO IMPROVE ERYTHROCYTE MEMBRANE ON HYPERCHOLESTEROL RATS

“…Sesame oil, known to have antioxidant effects associated with the characteristics of its components 5 . Sesame oil contains approximately 0.3-0.5% sesamolin, 1-4% sesamol and 0.5-1% sesamin 6 .…”

Assessment of effectiveness of synthetic diacylglycerols as emulsifiers in dispersion systems containing interesterified Turkey fat

“…Moreover, sesame oil is a supplement with known anti-inflammatory properties and can reduce the risk of cardiovascular disease. Current studies have shown that this oil can reduce low-density lipoprotein (LDL) while maintaining high-density lipoprotein (HDL) levels [20]. Sesame oil is extremely resistant to oxidative rancidity [21].…”