Anti-Inflammatory and Antioxidant Effects of Dietary Supplementation and Lifestyle Factors

Roberts, Llion A.

doi:10.3390/antiox10030371

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Given its proven positive effect on hypertension and cardiovascular health, it would be beneficial to study the effects of physical activity on the changes in exercise-related miRNAs that control the activity of IL-1β. The impact of diet and the use of food supplements on miRNA regulation of inflammation has also been considered a necessary area of study [87]. For example, in a 2019 study, obese individuals exposed to a ketogenic diet exhibited miRNA levels similar to lean subjects [88].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1β in Multifactorial Hypertension: Inflammation, Vascular Smooth Muscle Cell and Extracellular Matrix Remodeling, and Non-Coding RNA Regulation

Melton

Qiu

2021

IJMS

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The biological activities of interleukins, a group of circulating cytokines, are linked to the immuno-pathways involved in many diseases. Mounting evidence suggests that interleukin-1β (IL-1β) plays a significant role in the pathogenesis of various types of hypertension. In this review, we summarized recent findings linking IL-1β to systemic arterial hypertension, pulmonary hypertension, and gestational hypertension. We also outlined the new progress in elucidating the potential mechanisms of IL-1β in hypertension, focusing on it’s regulation in inflammation, vascular smooth muscle cell function, and extracellular remodeling. In addition, we reviewed recent studies that highlight novel findings examining the function of non-coding RNAs in regulating the activity of IL-1β and its associated proteins in the setting of hypertension. The information collected in this review provides new insights into understanding the pathogenesis of hypertension and could lead to the discovery of new anti-hypertensive therapies to combat this highly prevalent disease.

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Section: Discussionmentioning

confidence: 99%

Interleukin-1β in Multifactorial Hypertension: Inflammation, Vascular Smooth Muscle Cell and Extracellular Matrix Remodeling, and Non-Coding RNA Regulation

Melton

Qiu

2021

IJMS

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“…PE is considered a valuable non-pharmacological therapy, but it must be included in a lifestyle strategy designed to enhance overall wellbeing, in which diet also plays an important role. This combination can beneficially influence oxidative stress and inflammation levels [ 213 ].…”

Section: State Of the Artmentioning

confidence: 99%

Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects

et al. 2022

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Studies show that the autonomic nervous system (ANS) has an important impact on health in general. In response to environmental demands, homeostatic processes are often compromised, therefore determining an increase in the sympathetic nervous system (SNS)’s functions and a decrease in the parasympathetic nervous system (PNS)’s functions. In modern societies, chronic stress associated with an unhealthy lifestyle contributes to ANS dysfunction. In this review, we provide a brief introduction to the ANS network, its connections to the HPA axis and its stress responses and give an overview of the critical implications of ANS in health and disease—focused specifically on the immune system, cardiovascular, oxidative stress and metabolic dysregulation. The hypothalamic–pituitary–adrenal axis (HPA), the SNS and more recently the PNS have been identified as regulating the immune system. The HPA axis and PNS have anti-inflammatory effects and the SNS has been shown to have both pro- and anti-inflammatory effects. The positive impact of physical exercise (PE) is well known and has been studied by many researchers, but its negative impact has been less studied. Depending on the type, duration and individual characteristics of the person doing the exercise (age, gender, disease status, etc.), PE can be considered a physiological stressor. The negative impact of PE seems to be connected with the oxidative stress induced by effort.

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“…Subjects with COPD (compared to healthy controls) who follow a diet with lower antioxidant content (low proteins, defective intake of iron, calcium, potassium, zinc, folate, vitamin B6, retinol) show a reduction in lung function with a higher risk of developing COPD [ 244 , 245 ]. The in vivo and in vitro models of inflammation induced by bleomycin, lipopolysaccharide and cigarette smoke demonstrate the antioxidant and anti-inflammatory properties of these compounds [ 246 , 247 ]. Additionally, some researchers show that high-intake dietary antioxidants protect against the progression of lung disease but this increases in mice exposed to cigarette smoke.…”

Section: New Pharmacological Perspectives In Airway Diseases: Antioxi...mentioning

confidence: 99%

Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases

et al. 2022

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Inflammation of the human lung is mediated in response to different stimuli (e.g., physical, radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental pollutants. They often promote an increase in inflammatory activities in the airways that manifest themselves as chronic diseases (e.g., allergic airway diseases, asthma, chronic bronchitis/chronic obstructive pulmonary disease (COPD) or even lung cancer). Increased levels of oxidative stress (OS) reduce the antioxidant defenses, affect the autophagy/mitophagy processes, and the regulatory mechanisms of cell survival, promoting inflammation in the lung. In fact, OS potentiate the inflammatory activities in the lung, favoring the progression of chronic airway diseases. OS increases the production of reactive oxygen species (ROS), including superoxide anions (O2−), hydroxyl radicals (OH) and hydrogen peroxide (H2O2), by the transformation of oxygen through enzymatic and non-enzymatic reactions. In this manner, OS reduces endogenous antioxidant defenses in both nucleated and non-nucleated cells. The production of ROS in the lung can derive from both exogenous insults (cigarette smoke or environmental pollution) and endogenous sources such as cell injury and/or activated inflammatory and structural cells. In this review, we describe the most relevant knowledge concerning the functional interrelation between the mechanisms of OS and inflammation in airway diseases.

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Anti-Inflammatory and Antioxidant Effects of Dietary Supplementation and Lifestyle Factors

Abstract: Trends relating to specific diets and lifestyle factors like physical (in) activity have formed in recent times [...]

Cited by 4 publications

References 24 publications

Interleukin-1β in Multifactorial Hypertension: Inflammation, Vascular Smooth Muscle Cell and Extracellular Matrix Remodeling, and Non-Coding RNA Regulation

Interleukin-1β in Multifactorial Hypertension: Inflammation, Vascular Smooth Muscle Cell and Extracellular Matrix Remodeling, and Non-Coding RNA Regulation

Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects

Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases

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