Anti-inflammatory and antioxidant activity of astragalus polysaccharide in ulcerative colitis: A systematic review and meta-analysis of animal studies

Hu, Hengchang; Zhang, Wei; Xiong, Peiyu; Li, Song; Jia, Bo; Liu, Xinglong

doi:10.3389/fphar.2022.1043236

Cited by 18 publications

(5 citation statements)

References 66 publications

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“…Amino salicylates scavenge ROS superoxide and recover SOD activity, NF-kB, MPO, and proinflammatory cytokine production. The inhibitory effect of 5-aminosalicylic acid and acetylsalicylic acid on NETosis was proved, making them a potentially ideal supplementary therapy in NET-related kidney disorders (205,206).…”

Section: Antioxidantsmentioning

confidence: 99%

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Antioxidantsmentioning

confidence: 99%

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases

2024

Frontiers Research Topics

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Section: Antioxidantsmentioning

confidence: 99%

NETosis: an emerging therapeutic target in renal diseases

Juha,

Molnár,

Jakus

et al. 2023

Front. Immunol.

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IntroductionNeutrophil extracellular traps (NETs) are web-like structures composed of nuclear and granular components. The primary role of NETS is to prevent the dissemination of microbes and facilitate their elimination. However, this process is accompanied by collateral proinflammatory adverse effects when the NET release becomes uncontrollable, or clearance is impaired. Although NET-induced organ damage is conducted primarily and indirectly via immune complexes and the subsequent release of cytokines, their direct effects on cells are also remarkable. NETosis plays a critical pathogenic role in several renal disorders, such as the early phase of acute tubular necrosis, anti-neutrophil cytoplasmic antibody-mediated renal vasculitis, lupus nephritis, thrombotic microangiopathies, anti-glomerular basement membrane disease, and diabetic nephropathy. Their substantial contribution in the course of these disorders makes them a desirable target in the therapeutic armamentarium. This article gives an in-depth review of the heterogeneous pathogenesis and physiological regulations of NETosis and its pivotal role in renal diseases. Based on the pathogenesis, the article also outlines the current therapeutic options and possible molecular targets in the treatment of NET-related renal disorders.MethodsWe carried out thorough literature research published in PubMed and Google Scholar, including a comprehensive review and analysis of the classification, pathomechanisms, and a broad spectrum of NET-related kidney disorders.ConclusionsNETosis plays a pivotal role in certain renal diseases. It initiates and maintains inflammatory and autoimmune disorders, thus making it a desirable target for improving patient and renal outcomes. Better understanding and clinical translation of the pathogenesis are crucial aspects to treatment, for improving patient, and renal outcomes.

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“…Hu et al performed a meta-analysis and concluded that APS treatment dramatically relieved colonic damage by reversing the levels of DAI, CMDI, CHS, TNF-α, IL-6, IL-1β, MPO, MDA, and SOD [104]. Pre-and post-addition of APS (100 µg/mL) could downregulate the expression of inflammation indicators and levels of short circuit current while increasing the mRNA expression of ZO-1 and occludin in LPS-infected Caco-2 cells [105] (Table 3).…”

Section: Astragalus Polysaccharidementioning

confidence: 99%

Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals

Yang,

Xiao,

Cheng

et al. 2023

Molecules

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Intestinal inflammation is a chronic gastrointestinal disorder with uncertain pathophysiology and causation that has significantly impacted both the physical and mental health of both people and animals. An increasing body of research has demonstrated the critical role of cellular signaling pathways in initiating and managing intestinal inflammation. This review focuses on the interactions of three cellular signaling pathways (TLR4/NF-κB, PI3K-AKT, MAPKs) with immunity and gut microbiota to explain the possible pathogenesis of intestinal inflammation. Traditional medicinal drugs frequently have drawbacks and negative side effects. This paper also summarizes the pharmacological mechanism and application of Chinese herbal compounds (Berberine, Sanguinarine, Astragalus polysaccharide, Curcumin, and Cannabinoids) and formulae (Wumei Wan, Gegen-Qinlian decoction, Banxia xiexin decoction) against intestinal inflammation. We show that the herbal compounds and formulae may influence the interactions among cell signaling pathways, immune function, and gut microbiota in humans and animals, exerting their immunomodulatory capacity and anti-inflammatory and antimicrobial effects. This demonstrates their strong potential to improve gut inflammation. We aim to promote herbal medicine and apply it to multispecies animals to achieve better health.

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Anti-inflammatory and antioxidant activity of astragalus polysaccharide in ulcerative colitis: A systematic review and meta-analysis of animal studies

Cited by 18 publications

References 66 publications

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases

Emerging molecular mechanisms and therapeutics of autoimmune liver or kidney diseases

NETosis: an emerging therapeutic target in renal diseases

Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals

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