Anti-inflammatory and antinociceptive properties of blueberry extract<i>(Vaccinium corymbosum</i>)

Torri, Eliane; Lemos, Marivane; Caliari, Vinícius; Kassuya, Cândida Aparecida Leite; Bastos, Jairo Kenupp; Andrade, Sérgio Faloni de

doi:10.1211/jpp.59.4.0015

Cited by 45 publications

(23 citation statements)

References 29 publications

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“…These results could be attributed to the structural features of the polyphenols and/or other compounds present in each fruit extract. Compared to previously published works, TP reported in the present study was lower than those reported in maqui (4570 mg GAE/ 100g DW 19 ), calafate (3490 mg GAE/100 g DW 20 ), and blueberry extracts (5660 mg catechin equivalents/100 g fresh weight [FW] 21 ). This could be explained by the use of a nonacidified hydroalcoholic extract, which probably resulted in a decrease extraction efficiency of anthocyanins FIG.…”

Section: It Has Been Recognized That Increased Body Adiposity Is Habicontrasting

confidence: 96%

Chilean Native Fruit Extracts Inhibit Inflammation Linked to the Pathogenic Interaction Between Adipocytes and Macrophages

Reyes-Farías

Vasquez

Ovalle-Marin

et al. 2015

Journal of Medicinal Food

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Obesity is characterized by an increase in the infiltration of monocytes into the adipose tissue, causing an inflammatory condition associated with, for example, the development of insulin resistance. Thus, anti-inflammatory-based treatments could emerge as a novel and interesting approach. It has been reported that Chilean native fruits maqui (Aristotelia chilensis) and calafate (Berberis microphylla) present high contents of polyphenols, which are known for their antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the ability of extracts of these fruits to block the pathogenic interaction between adipocytes and macrophages in vitro and to compare its effect with blueberry (Vaccinium corymbosum) extract treatment, which has been already described to possess several biomedical benefits. RAW264.7 macrophages were treated with 5 μg/mL lipopolysaccharides (LPS), with conditioned media (CM) from fully differentiated 3T3-L1 adipocytes, or in a coculture (CC) with 3T3-L1 adipocytes, in the presence or absence of 100 μM [total polyphenolic content] of each extract for 24 h. The gene expression and secretion profile of several inflammatory markers were evaluated. Nitric oxide secretion induced by LPS, CM, and CC was reduced by the presence of maqui (-12.2%, -45.6%, and -14.7%, respectively) and calafate (-27.6%, -43.9%, and -11.8%, respectively) extracts. Gene expression of inducible nitric oxide synthase and TNF-α was inhibited and of IL-10 was induced by maqui and calafate extract incubation. In conclusion, the extracts of these fruits present important inhibitory-like features over the inflammatory response of the interaction between adipocytes and macrophages, comprising a potential therapeutic tool against comorbidities associated with obesity development.

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Section: It Has Been Recognized That Increased Body Adiposity Is Habicontrasting

confidence: 96%

Chilean Native Fruit Extracts Inhibit Inflammation Linked to the Pathogenic Interaction Between Adipocytes and Macrophages

Reyes-Farías

Vasquez

Ovalle-Marin

et al. 2015

Journal of Medicinal Food

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“…Vaccinium corymbosum, isolated from blueberries, shows anti-inflammatory and antinociceptive activities. Thus, its consumption will be beneficial for the therapy of inflammatory diseases (Torri et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Zhong

Wang

Guo

et al. 2015

Tohoku J. Exp. Med.

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Juvenile idiopathic arthritis (JIA) is the most common arthritis in the adolescents under the age of 16. Etanercept, an inhibitor of tumor necrosis factor, is often used to treat JIA despite its significant side effects. Homeopathic remedies, such as blueberries, have anti-inflammatory properties with fewer unwanted effects and should be considered as a primary treatment. We aimed to explore the efficacy and safety of combination therapy of blueberry and etanercept for JIA. Two hundred and one JIA patients were selected, and randomly and evenly assigned to three groups: ETA (50 mg of etanercept twice weekly), ETABJ (matched etanercept and 50 ml blueberry juice daily) and ETAPJ (matched etanercept and placebo juice). The severity of JIA was measured using American College of Rheumatology scales (ACR) 20, 50 and 70. The levels of pro-inflammatory cytokines, interleukin-1 (IL1) alpha and IL1 beta, and interleukin-1 receptor antagonist (IL1RA) were measured by qRT-PCR and ELISA. After a 6-month follow-up, the ACR20, ACR50 and ACR70 in an ETABJ group were higher than those in other two groups (P < 0.05), suggesting clinically meaningful improvement in JIA. Meanwhile, the symptoms and side effects were reduced significantly or absent in an ETABJ group, including mental diseases, retrobulbar optic neuritis, gaining weight, infection, cutaneous vasculitis, diarrhea, uveitis and pancytopenia. Blueberries reduced the levels of IL1 alpha and beta, and increased the level of IL1RA. Thus, a combination therapy of blueberry and etanercept can reduce the severity of JIA and should be developed as a new method for JIA therapy.

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“…40 Evaluation of the pharmacological properties of the compounds isolated from the active fractions pointed out that anthocyanins possess strong antioxidant=anti-inflammatory activities, as well as the ability to inhibit lipid peroxidation and the inflammatory mediators cyclooxygenase-1 and -2, including cell migration. Cyanidins are reported to possess anti-inflammatory properties comparable to those of commercial products naproxen and ibuprofen.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Studies on the Antinociceptive Activity of Vaccinium ashei Berry in Experimental Animal Models

Ramirez

Guterres

Dickel

et al. 2010

Journal of Medicinal Food

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The aim of this study was to carry out pharmacological screening in order to evaluate the potential effects of lyophilized fruits of different cultivars of Vaccinium ashei Reade (Family Ericaceae) berries, commonly known as rabbiteye blueberries, on nociception. This was achieved using the formalin, hot plate, tail-flick, and writhing tests in mice. During this experiment the mice consumed approximately 3.2-6.4 mg=kg=day (p.o.) of the anthocyanins. The extract was administered for 21 days or 60 minutes before test. Morphine and diclofenac (10 mg=kg, p.o.) as the standard drug (positive control) and water (via oral gavage) as the negative control were administered before all tests. The blueberry extract produced a significant decrease in constrictions induced by acetic acid and caused graded inhibition of the second phase of formalin-induced pain. Moreover, in both the hot plate and tail-flick tests, it significantly increased the threshold. These data suggest that the extract from V. ashei produced antinociceptive effects, as demonstrated in the experimental models of nociception in mice. Additional experiments are necessary in order to clarify the true target for the antinociceptive effects of rabbiteye blueberry extract.

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Anti-inflammatory and antinociceptive properties of blueberry extract(Vaccinium corymbosum)

Cited by 45 publications

References 29 publications

Chilean Native Fruit Extracts Inhibit Inflammation Linked to the Pathogenic Interaction Between Adipocytes and Macrophages

Chilean Native Fruit Extracts Inhibit Inflammation Linked to the Pathogenic Interaction Between Adipocytes and Macrophages

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Preliminary Studies on the Antinociceptive Activity of Vaccinium ashei Berry in Experimental Animal Models

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