Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study

Cardoso, Larissa Colonetti; Pinto, Natália Bitú; Nobre, Maria Elizabeth Pereira; Silva, M.R.; Pires, Glauber Magalhães; Lopes, Maria Janice Pereira; Viana, G. S. B.; Rodrigues, Luciano Miller Reis

doi:10.1590/1414-431x20187773

Cited by 7 publications

(11 citation statements)

References 26 publications

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“…According to previous studies [11], the antibacterial properties of SNP are enhanced under the influence of low-frequency ultrasound (US) due to reduction of their agglomeration. In addition, US is also able to independently carry out a destructive effect on microorganisms and has a very important effect of phonophoresis, due to which the delivery of active substances into the thickness of the body tissues occurs [12]. This is especially important in the treatment of abscesses, phlegmon, postoperative complications, when it is necessary to ensure the availability of the drug in hard-to-reach places.…”

Section: Introductionmentioning

confidence: 99%

Cytological Examination of Experimental Purulent Wounds in the Treatment of Silver Nanoparticles in Ultrasound Cavitation

Myronov

Bugaiov

Tymakova

et al. 2019

EUMJ

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The treatment of purulent wounds is an important problem of modern surgery. Antibiotic resistance of bacteria dramatically reduces the effectiveness of traditional methods of treatment. Previous studies have indicated that silver nanoparticles have good antibacterial activity and do not cause bacterial resistance. Low-frequency ultrasound improves the bactericidal properties of nanoparticles, as well as plays an important role in cleaning wounds from purulent-necrotic tissue and delivering nanoparticles to the site of infection. The combination of the properties of silver nanoparticles and low-frequency ultrasound requires careful investigation in the treatment of purulent wounds. The purpose of the study was to substantiate the effectiveness of the treatment of purulent wounds with silver nanoparticles and low-frequency ultrasound by cytological examination. Materials and Methods. This study was carried out on 60 laboratory rats, which were equally divided into 3 groups. In the first group, treatment was carried out by low-frequency ultrasound; in the second group, a solution of silver nanoparticles was used together with low-frequency ultrasound; in the third, control group, a 0.05% Chlorhexidine solution was used. Silver nanoparticles with a size of 10-60 nm were synthesized by the polyol method. Results. The study showed that there were no statistically significant differences between the ultrasound, silver nanoparticles/ultrasound and Chlorhexidine groups on the first day. On the third day, a statistically significant increase in phagocytic neutrophilic leukocytes and fibroblasts was observed in the silver nanoparticles/ultrasound group compared with the first day. In comparison with the Chlorhexidine group, the number of monocytes (2.2 and 4.2 times) and macrophages (1.4 and 1.9 times) increased in the ultrasound and silver nanoparticles/ultrasound groups respectively, and the necrotic type of cytograms was not determined. On the seventh day, granulation tissue began to appear in the silver nanoparticles/ultrasound group, the percentage of leukocyte destruction decreased (by 4.5 times), microorganisms were almost not detected, regenerative types of cytograms appeared for the first time. The number of neutrophils in the control group exceeded the analogous parameter of the ultrasound group by 2.4 times and the silver nanoparticles/ultrasound group by 3.8 times. The number of fibroblasts became significantly larger in the ultrasound (2.2 times) and the silver nanoparticles/ultrasound (2.3 times) groups, compared with the group where Chlorhexidine was used. On the tenth day, the number of fibroblasts and cells of the monocytic-macrophage series increased in the control group, which indicates later regenerative processes. On the tenth day, there was a complete epithelization of wounds in the silver nanoparticles/ultrasound group, while healing occurred on day 12 in the ultrasound group, and on day 21 in the control group. Conclusions. The combined use of silver nanoparticles and low-frequency ultrasound significantly improves the cytological parameters of wound healing of purulent wounds and has clear advantages over the ultrasound monotherapy and the use of Chlorhexidine. The presented method reduces the treatment time and can be prospectively introduced into surgical practice.

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Section: Introductionmentioning

confidence: 99%

Cytological Examination of Experimental Purulent Wounds in the Treatment of Silver Nanoparticles in Ultrasound Cavitation

Myronov

Bugaiov

Tymakova

et al. 2019

EUMJ

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“…Association between algae consumption and a lower incidence of chronic degenerative diseases is also reported for The Japanese [363]. Carrageenan has been widely used as a tool in the screening of novel anti-inflammatory drugs [364]. Among others, Porphyra vietnamensis [365,366], Eucheuma Cottonii [367], Dichotomaria obtusata (Figure 17) [368], Cystoseira sedoides, Cladostephus spongiosis, Padina pavonica (Figure 18) [369], Ecklonia cava (due to phlorotannins) [370][371][372], Caulerpa racemose [373], Sarcodia ceylanica [374], actinotrichia fragilis [375], Dictyota menstrualis (Figure 19) [376], Gracilaria cornea [377], Gracilaria birdiae [378], Class Phaeophyceae, Rhodophyceae and Chlorophyceae [379], Caulerpa curpressoides [380,381], Ulva lactuca (Figure 20) [382], Sargassum wightii and Halophila ovalis [383], Grateloupia lanceolate [384], Sargassum fulvellum and Sargassum thunbergii [385], Briareum excavatum [386], Caulerpa racemose [387], Sargassum hemiphyllum [388], Laurencia obtusa [389], Caulerpa kempfii [390] Caulerpa cupressoides [391] are reported for their analgesic and anti-inflammatory properties.…”

Section: Analgesic and Anti-inflammatory Potentialmentioning

confidence: 75%

Seaweeds: A Comprehensive Review of Pharmacological Interests

Mohiuddin¹,

Bangladesh.²

2019

IJCPT

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According to the WHO, 2.3 billion adults are overweight and the prevalence is higher in females of childbearing age than males [1]. In the US, the economic burden is estimated to be about $100 billion annually [2]. Worldwide obesity causes 2.8 million deaths per year and 35.8 million disability-adjusted life-years, some 45% of diabetes, 25% of IHDs and up to 41% of certain cancers [3]. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins [4]. Alginates are amongst the seaweed fibers that are well-known for their anti-obesity effects. They have been shown to inhibit pepsin, pancreatic lipase [5], reduced body

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“…Association between algae consumption and a lower incidence of chronic degenerative diseases is also reported for The Japanese [363]. Carrageenan has been widely used as a tool in the screening of novel antiinflammatory drugs [364]. Among others, Porphyra vietnamensis [365,366], Eucheuma Cottonii [367], Dichotomaria obtusata ( Figure 17) [368], Cystoseira sedoides, Cladostephus spongiosis, Padina pavonica ( Figure 18) [369], Ecklonia cava (due to phlorotannins) [370][371][372], Caulerpa racemose [373], Sarcodia ceylanica [374], actinotrichia fragilis [375], Dictyota menstrualis ( Figure 19) [376], Gracilaria cornea [377], Gracilaria birdiae [378], Class Phaeophyceae, Rhodophyceae and Chlorophyceae [379], Caulerpa curpressoides [380,381], Ulva lactuca ( Figure 20) [382], Sargassum wightii and Halophila ovalis [383], Grateloupia lanceolate [384], Sargassum fulvellum and Sargassum thunbergii [385], Briareum excavatum [386], Caulerpa racemose [387], Sargassum hemiphyllum [388], Laurencia obtusa [389], Caulerpa kempfii [390] Caulerpa cupressoides [391] are reported for their analgesic and anti-inflammatory properties.…”

Section: Analgesic and Anti-inflammatory Potentialmentioning

confidence: 75%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study

Cited by 7 publications

References 26 publications

Cytological Examination of Experimental Purulent Wounds in the Treatment of Silver Nanoparticles in Ultrasound Cavitation

Cytological Examination of Experimental Purulent Wounds in the Treatment of Silver Nanoparticles in Ultrasound Cavitation

Seaweeds: A Comprehensive Review of Pharmacological Interests

Seaweeds: An Extensive Review of Medicinal Values

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