Anti‐Inflammatory and Antinociceptive Activities of Untreated, Germinated, and Fermented Mung Bean Aqueous Extract

Ali, Norlaily Mohd; Yusof, Hamidah Mohd; Yeap, Swee Keong; Ho, Wan Yong; Beh, Boon Kee; Long, Kamariah; Koh, Soo Peng; Abdullah, Md. Pauzi; Alitheen, Noorjahan Banu Mohamed

doi:10.1155/2014/350507

Cited by 31 publications

(25 citation statements)

References 18 publications

(23 reference statements)

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“…Inflammation is a defence mechanism by host against infections, foreign substances and tissue injury by activation of the cellular immune responses that stimulates various cytokines and nitric oxide which are known as pro-inflammatory mediators [2]. Excessive production of inflammatory mediators could, however, result in a chronic disease condition such as autoimmune disease and rheumatoid arthritis with features of redness, swelling, pain transmitted by peripheral or central nerves [3].…”

Section: Introductionmentioning

confidence: 99%

“…A number of mediators such as eicosanoids, reactive oxygen and nitrogen species, cytokines like tumor necrosis factor-α, interleukin-1β and interleukin-6 have been implicated in the pathogenesis of these inflammatory disorders which provides a plethora of targets for anti-inflammatory molecules [2]. Many drugs have been developed for the treatment of nociception and inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…(T. indica) (family: Fabaceae) is an important food in the tropics with numerous applications in chemicals, nutritional, textile and pharmaceutical industries [7]. It is indigenous to tropical Africa but it has been naturalized in more than 50 countries globally [2]. Tamarind has been characterized by the presence of all amino acids except tryptophan [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Protective effects of crude and alkaloidal extracts of Tamarindus indica against acute inflammation and nociception in rats

Jigam

Mahmood

Lawal

2017

JAD

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective effects of crude and alkaloidal extracts of Tamarindus indica against acute inflammation and nociception in rats

Jigam

Mahmood

Lawal

2017

JAD

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“…The main ingredient is tannin acid. In vitro and in vivo studies have demonstrated its pharmacological effects, including spermicidal, antibacterial, and antioxidant activities [ 8 , 9 ]. However, there are no reports about the analgesic and anti-inflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Analgesic and Anti‐Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models

Sun

Song

Jia

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Aim Pain and inflammation are associated with many diseases in humans and animals. Galla Chinensis, a traditional Chinese medicine, has a variety of pharmacological properties. The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models. Method The analgesic activities were evaluated by hot-plate and writhing tests. The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests. The contents of cytokines (NO, iNOS, PGE2, and IL-10) in serum of rats in paw edema test were inspected by ELISA assays. Results In the hot-plate test, Galla Chinensis could significantly extend pain threshold when compared to control group. The inhibitory rates of writhes ranged from 36.62% to 68.57% in Galla Chinensis-treated mice. Treatment with Galla Chinensis (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; P < 0.01). Galla Chinensis (1 g/kg) had significant (P < 0.05) anti-inflammatory activity in capillary permeability test (29.04%). In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% (P < 0.01) at 1 h and 2 h after administration of Galla Chinensis (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced. Conclusion These results suggest that Galla Chinensis has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain.

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“…A recent finding has suggested that antioxidant and anti‐inflammatory properties of mung bean coats can be greatly increased once fermented with fungi (Huang et al., ; Ali et al., ). Consequently, this process indicates the potential of the product of fermented mung bean seed coats (FMSC) in formulating diets for post‐weaned pigs as an antioxidant supplement.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus awamori‐fermented mung bean seed coats enhance the antioxidant and immune responses of weaned pigs

Lee

Hung

Yang

et al. 2017

Animal Physiology Nutrition

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The potential benefits of Aspergillus-fermented mung bean seed coats (FMSC) for weaned pigs remain unexplored. Both in vitro and in vivo experiments were employed to evaluate the potential of FMSC supplement on the growth, antioxidant and immune responses of weaned pigs. The total polyphenols and DPPH scavenging capability of ethanol extract of FMSC exhibited a greater (p < 0.01) increase than those of pre-fermentation. With the addition of the polyphenol of FMSC extract, an increase in phagocytosis by neutrophils and proliferation of peripheral blood mononuclear cells (PBMC) were found. However, these observations were significantly inhibited (p < 0.05) in those activated cells. Next, 96 weaned pigs were allotted with a randomized complete block design into four dietary treatments, including 0 (control), 600, 1200 or 1800 mg/kg FMSC in a corn-soya bean meal basal diet for a 35-day trial. The pigs were injected with swine enzootic pneumonia (SEP) vaccines at day 3 and day 21 respectively. The results showed that dietary treatment failed to affect growth performance or serum SEP titre. The diet supplemented with 600-1800 mg/kg FMSC decreased faecal lactoferrin on day 21 and increased plasma trolox equivalent antioxidant capacity (TEAC) and erythrocytes catalase activity, as well as decreased (p < 0.01) plasma malondialdehyde (MDA) concentration on day 35. Diet supplementation of 1800 mg/kg FMSC increased phagocytosis by neutrophils and PBMC proliferation induced by pokeweed mitogen (PWM). However, the polymorphonuclear leucocytes (PMN)-positive respiratory burst cells were decreased in the supplementation of 1200 or 1800 mg/kg FMSC respectively. In addition, the serum haptoglobin concentration was decreased in the supplementation with 1200 mg/kg FMSC. Taken together, FMSC enriches polyphenols with antioxidative and immune modulated properties. After feeding FMSC, an improvement in antioxidative capability and immunocompetence was found, implying that FMSC could provide as a feed additive at optimal level 1200 mg/kg for weaned pigs.

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Anti‐Inflammatory and Antinociceptive Activities of Untreated, Germinated, and Fermented Mung Bean Aqueous Extract

Cited by 31 publications

References 18 publications

Protective effects of crude and alkaloidal extracts of Tamarindus indica against acute inflammation and nociception in rats

Protective effects of crude and alkaloidal extracts of Tamarindus indica against acute inflammation and nociception in rats

Evaluation of Analgesic and Anti‐Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models

Aspergillus awamori‐fermented mung bean seed coats enhance the antioxidant and immune responses of weaned pigs

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