Anti-inflammatory and antinociceptive activities of Trewia polycarpa roots

Chamundeeswari, D.; Vasantha, J; Gopalakrishnan, S.; Sukumar, E.

doi:10.1016/j.fitote.2004.07.001

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…These observations indicate an increased ROS production, the deactivation of SOD, GSH and thus increased levels of lipid peroxidation. These results are supported by the reports of Chamundeeswari et al (2004) and Mythilypriya et al (2007).…”

Section: Discussionsupporting

confidence: 91%

“…Several reports have shown that during inflammatory joint diseases, such as adjuvant-induced arthritis, joint diseases, phagocytes accumulate in the joints and produce superoxide radicals and hydrogen peroxide, which in the presence of traces of iron salts found in synovial fluids, interact to form the highly reactive hydroxyl radical (OHÁ). Thus, free radicals might contribute in the biochemical changes (Fahim et al 1995;Chamundeeswari et al 2004). In order to reduce the damage caused by the ROS, multiple defense systems collectively called antioxidants are present in both human and in animals.…”

Section: Discussionmentioning

confidence: 99%

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Protective potential of MMR vaccine against complete Freund’s adjuvant-induced inflammation in rats

et al. 2011

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The aim of the present study was to investigate the effect of MMR vaccine on inflammation which was induced by complete Freund's adjuvant (CFA) in male Sprague-Dawley rats. Rats were randomly divided into the control, CFA, MMR and CFA + MMR groups. Inflammatory symptoms such as paw oedema was measured in CFA-injected rats' paw. Body weight changes and alterations in some haematological parameters and oxidative stress markers following CFA injection were checked. In CFA-inflammed rats, there was a significant increase in rat paw thickness and decrease in body weight increment. MMR exhibited a significant anti-inflammatory effect as manifested by reduction in paw thickness and normal gain in body weight when administered 1 week prior to induction of inflammation. The altered haematological parameters (TLC) and oxidative stress markers (MDA, GSH, SOD) in the inflammed rats were significantly brought back to near normal by MMR treatment. In conclusion, MMR vaccine showed a reduction in rat paw thickness and it could significantly normalize the haematological and biochemical abnormalities in CFA-induced inflammatory pain model in rats. Our data suggested that MMR could be a potential protective agent against certain types of inflammatory pain. Further histopathological and radiological studies are required to confirm the possibility of developing novel therapeutic vaccines against some forms of arthritis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Protective potential of MMR vaccine against complete Freund’s adjuvant-induced inflammation in rats

et al. 2011

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“…A total of 60 mice were divided randomly into 12 groups. Acute edema was induced by injection of carrageenan 1% into the sub-plantar region of hind-paw of mice (Chamundeeswari et al, 2004;Tjandrawinata et al, 2015). The mice of group I, as a negative control group for avocado peel infusion and decoction, were given aquadest.…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory effects of avocado peels against inflammation induced by carrageenan in mice

et al. 2019

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The aim of this research is to investigate the anti-inflammatory activity of avocado peel against carrageenan-induced inflammation in mice. The group of mice that was used as a negative control group to test the anti-inflammatory activity of infusion and decoction (group I) were given aquadest, while the group for testing the activity of extract (group II) was given CMC-Na. The positive control group (group III) was given potassium diclofenac. Groups IV-VI were given avocado peel infusion with the following doses 667.5; 1335; and 2670 mg/kgBW respectively. Groups VII-IX were given avocado peel decoction with the same doses as the previous groups. Groups X-XII were given 830; 1670; and 3330 mg/kgBW of avocado peel extract respectively. The paw edema were measured using a digital caliper for 6 hours afterwards after carrageenan injection. There were a significant (p<0.05) reduction in paw edema at all doses of infusion, decoction, and extract of avocado peel. Based on the research, it can be concluded that the avocado peels have anti-inflammatory activities.

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“…Acute edema was induced by the injection of carrageenan1% (prepared in normal saline) into the sub-plantar region of hind-paw of mice [11]. Then, each group was treated orally with 1% CMC-Na (negative control), 4.48 mg/kg BW of diclofenac sodium (positive control), and treatment doses of 105, 210 and 420 mg/kg BW EL [10].…”

Section: Anti-inflammatory Studymentioning

confidence: 99%

“…The analgesic activity of EL was tested using acetic acid-induced writhing method [11,14,15,17]. Female mice Swiss were divided randomly into five groups (n=5).…”

Section: Analgesic Studymentioning

confidence: 99%

Evaluation of Antihyperlipidemic, Anti-Inflammatory, and Analgesic Activities of Eurycoma Longifolia in Animal Models

Hendra

Fenty

Andreani

et al. 2017

Int J Pharm Pharm Sci

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Objective: To investigate the anti-hyperlipidemic, anti-inflammatory and analgesic properties of of E. longifolia root extract in animal models. Methods:In this study, glucose-fructose enriched diet-induced hyperlipidemia, carrageenan-induced paw edema and acetic acid-induced writhing were used to evaluate the anti-hypertriglyceridemia, anti-inflammatory and analgesic activities, respectively. At the end of the experiment of glucose-fructose enriched diet-induced hyperlipidemia, blood samples were collected and estimation of blood lipids were carried out. Edema thickness was measured using digital caliper at 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, and 360 min after carrageenan injection. The number of abdominal writhing for each mouse was observed and counted during a period of 1 h post injection of acetic acid.Results: E. longifolia root extract demonstrated a significant reduction of triglyceride levels (p<0.05) compared with the control group in glucosefructose enrich diet in rats. In anti-inflammatory test, the extract significantly inhibited the carrageenan induced paw edema formation (p<0.05). The extract also significantly decreased the number of writhing in acetic acid-induced mice (p<0.05).Conclusion: E. longifolia root extract shown a significant anti-hypertriglyceridemia, anti-inflammatory and analgesic activities. Further studies are needed to determine mechanisms for its acitivities of E. longifolia root extract.

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Anti-inflammatory and antinociceptive activities of Trewia polycarpa roots

Cited by 5 publications

References 4 publications

Protective potential of MMR vaccine against complete Freund’s adjuvant-induced inflammation in rats

Protective potential of MMR vaccine against complete Freund’s adjuvant-induced inflammation in rats

Anti-inflammatory effects of avocado peels against inflammation induced by carrageenan in mice

Evaluation of Antihyperlipidemic, Anti-Inflammatory, and Analgesic Activities of Eurycoma Longifolia in Animal Models

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