Anti-Inflammatory and Antifibrotic Effects of a Combination of Spiperone and Immobilized Hyaluronidase on Partially Reversible and Irreversible Toxic Pneumofibrosis
Abstract:The possibility of boosting antifibrotic activity of testicular hyaluronidase immobilized on polyethylene oxide with spiperone was studied on the bleomycin models of a single (partially reversible pneumofibrosis) and repeated (irreversible pneumofibrosis) injuries to the alveolar epithelium in C57Bl/6 mice. The antifibrotic effect was more pronounced after successive treatment with immobilized hyaluronidase and spiperone than after individual treatment with each of the compounds: no collagen deposition in the … Show more
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