Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models

Abstract

Introduction The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract.

Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract

“…Piperine inhibited the expression of IL6 and Matrix Metalloproteinase (MMP) 13 and reduced the production of PGE2 in a dose dependant manner at concentrations of 10 to 100 μg/ml [15]. In a study by Chuchawankul et al, Piperine also inhibited IL-2 and Interferon (IFN)-γ production by activated PBMCs in a dosedependent manner [16].…”

Piperine and Its Various Physicochemical and Biological Aspects: A Review

“…Along with anti-inflammatory activity piperine also shows antiarthritic activity [104]. Piperine was also isolate from the bark of Careya arborea, found to possess significant central and peripheral analgesic activity at oral doses of 10, 20 and 30 mg/kg body weight against acetic acid induced writhing in mice.…”

Synthesis and Structure Activity Relationship of Some Indole Derivatives as Potential Anti-inflammatory Agents

“…[8][9][10] 5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl The NSAIDs have exerted their anti-inflammatory activities through cyclooxygenase (COX) inhibition. [11][12][13] Structural variation of the heterocyclic rings through the manipulation of the heterocyclic core influences the activity of the resulting fused systemes, among these of pyrroles and their fused deivatives. [14][15][16] Due to their pharmaceutical importance, [17][18][19][20][21][22] attention was paid to develop a new synthetic route for pyrroles and their fused forms.…”