Anti-inflammatory and Antiapoptotic Effect of Interleukine-18 Binding Protein on the Spinal Cord Ischemia-Reperfusion Injury

Karavelioğlu, Ergün; Gönül, Yücel; Kokulu, Serdar; Hazman, Ömer; Bozkurt, Mehmet Fatih; Koçak, Ahmet; Eser, Olcay

doi:10.1007/s10753-014-9811-7

Cited by 20 publications

(9 citation statements)

References 39 publications

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“…5 Transgenic overexpression of IL-18BP and exogenous IL-18BP administration significantly suppress IL-18 function and attenuate I/R injury in several organs, such as the heart, kidney, and spinal cord. [31][32][33][34] In liver injury models, the protective effects of IL-18BP have also been demonstrated. For example, FIGURE 5.…”

Section: Discussionmentioning

confidence: 99%

Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling

Liu

Pan

et al. 2015

Transplantation

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Section: Discussionmentioning

confidence: 99%

Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling

Liu

Pan

et al. 2015

Transplantation

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“…Cellular damage, DNA fragmentation, apoptosis, and increased activity of nuclear kappa B (NF-κB) cause local and systemic organ damage [ 12 ]. Proinflammatory cytokines such as IL-1, IL-6, IL-18, TNF-α, and IFN-γ have important roles, especially in the pathophysiology of reperfusion injury [ 13 ]. Hepatic IR injury is a complex mechanism involving many cytokines, endothelin, and oxygen free radicals and it may also frequently appear in the clinical practice after liver trauma, liver transplantation, and liver resection.…”

Section: Discussionmentioning

confidence: 99%

Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

et al. 2015

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PurposeSevere local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury.MethodsWistar-Albino rats were divided into three groups that contained seven rats. Group I (sham): Laparotomy and infrarenal abdominal aorta (AA) dissection were done but no clamping was done. Group II (I/R): The infrarenal AA was clamped by atraumatic microvascular clamp for 30 minutes and then was exposed to 90 minutes of reperfusion. Group III (IR + IL-18BP): 75 µg/kg of IL-18BP in 0.9% saline (1 mL) was administered 30 minutes before infrarenal AA dissection and clamping; 30 minutes of ischemia was applied and then was exposed to 90 minutes of reperfusion.ResultsSerum AST, ALT, and LDH levels were remarkably higher in IR group and returned to normal levels in treatment group. The proinflammatory cytokine levels had decreased in treatment group, and was statistically significant compared with the IR group. Serum levels of total oxidant status and oxidative stress index decreased and levels of total antioxidant status increased by IL-18BP.ConclusionThis study suggested that IL-18BP has antioxidant, anti-inflammatory and hepatoprotective effects in cases of IR with infrarenal AA induced liver oxidative damage.

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“…Proinflammatory cytokines tend to be the more prevalently used outcome variables, as increased proinflammatory cytokines have consistently demonstrated to indicate worsening of the immune system, and may therefore be reliable and direct indicators of disease progression [32]. In addition, despite serum proinflammatory cytokines being peripheral in nature, they have been described as mediators of many pathways underlying the CNS through its important roles in inflammatory response [38], therefore may provide valuable insight with regards to the pathophysiology of PTSD from a CNS perspective. Proinflammatory cytokines increase in concentration with age but also may be elevated with stress as well as secondary symptoms of stress such as sleep and fatigue [24].…”

Section: Roles Of Proinflammatory Cytokines In Ptsd: Il-1β Il-6 Tnfmentioning

confidence: 99%

Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective

2020

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Post-traumatic stress disorder (PTSD) is a chronic condition characterized by symptoms of physiological and psychosocial burden. While growing research demonstrated signs of inflammation in PTSD, specific biomarkers that may be representative of PTSD such as the detailed neural correlates underlying the inflammatory responses in relation to trauma exposure are seldom discussed. Here, we review recent studies that explored alterations in key inflammatory markers in PTSD, as well as neuroimaging-based studies that further investigated signs of inflammation within the brain in PTSD, as to provide a comprehensive summary of recent literature with a neurological perspective. A search was conducted on studies published from 2009 through 2019 in PubMed and Web of Science. Fifty original articles were selected. Major findings included elevated levels of serum proinflammatory cytokines in individuals with PTSD across various trauma types, as compared with those without PTSD. Furthermore, neuroimaging-based studies demonstrated that altered inflammatory markers are associated with structural and functional alterations in brain regions that are responsible for the regulation of stress and emotion, including the amygdala, hippocampus, and frontal cortex. Future studies that utilize both central and peripheral inflammatory markers are warranted to elucidate the underlying neurological pathway of the pathophysiology of PTSD.

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Anti-inflammatory and Antiapoptotic Effect of Interleukine-18 Binding Protein on the Spinal Cord Ischemia-Reperfusion Injury

Cited by 20 publications

References 39 publications

Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling

Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling

Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective

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