Anti‐inflammatory and anti‐peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation

Abstract

This study was designed to reveal the possible involvement of thyroid hormones, if any, in diacerein induced alterations in glucose metabolism and tissue lipid peroxidation (LPO) in the animal model of carrageenan-induced inflammation. We studied the influence of diacerein administration on the changes in carrageenan-induced thyroid dysfunction; hepatic, renal and cardiac LPO as well as serum glucose, thyroid hormones and insulin concentrations in Wistar rats. Alterations in paw volume, serum levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol and triglycerides as well as hepatic, renal and cardiac reduced glutathione (GSH) contents were also studied as supporting parameters. While a decrease in the level of serum thyroid hormones and HDL-C and in tissue GSH content was observed in carrageenan-treated animals, it increased paw volume, the concentration of other serum lipids, glucose and insulin as well as tissue LPO. However, following diacerein administration for 21 days to carrageenan-treated animals, level of thyroid hormones and all other thyroid dependent parameters were reversed suggesting that the drug might be acting through stimulation in the thyroid functions.

Chronic Carrageenan Toxicity and the Possible Ameliorative Role of Diacerein in Experimental Animals

“…In this study, T4 was decreased significantly due to oral intake of carrageenan and that results are in accordance with Jatwa & Kar, (2009), who observed significant decrease in the serum concentrations of T4 following carrageenan administration. Carrageenan is known to induce inflammation, which resulted in depressed activity of thyroid gland (Borthakur et al, 2007).…”

“…Carrageenan-induced hypothyroidism appears to be an outcome of increased IL-1 level, which in turn decreases serum concentration of T4 and T3 (Singh et al, 2014). The level of serum T4 level was significantly increased by administration of diacerein in group V. Jatwa & Kar, (2009) found that the levels of both thyroid hormones were regulated after diacerein administration. Their study concluded that administration of diacerein with Carageenan regulates thyroid functions both at the glandular level (the only source of T4 generation) and at the level of peripheral conversion of T4 to T3 (the major process of T3 formation).…”

“…A dose of 30 mg/kg/day was given orally 30 min before carrageenan by a gavage for 3 months. This anti-inflammatory and antioxidant dose was chosen according to Kar, 2009 andMarwa et al, 2016).…”

New Opportunities Therapy in Patients With Knee Joint Osteoarthritis and Metabolic Syndrome

“…На фоне терапии диацереи-ном достоверно улучшились показатели липидограммы -снизились уровни ЛПНП (р < 0,001) и ТГ (р < 0,01). Полученные данные не противоречат литературным и связаны с плейотропными эффектами препарата [29,41]. А.В.…”

“…Наши результаты соответствуют данным, полученным другими исследователями, которые считают, что диаце-реин может участвовать в регуляции деятельности щито-видной железы [41]. В ряде работ, в т. ч. эксперименталь-ных, было подтверждено [29,41], что при приеме препа-рата наблюдается положительная динамика, связанная с нормализацией концентраций гормонов щитовидной железы. Однако механизмы развития данного эффекта точно не установлены, что требует дальнейшего изучения данного вопроса.…”