Anti-inflammatory and anti-periductal fibrosis effects of an anthocyanin complex in Opisthorchis viverrini-infected hamsters

Intuyod, Kitti; Priprem, Aroonsri; Limphirat, Wanwisa; Charoensuk, Lakhanawan; Pinlaor, Porntip; Pairojkul, Chawalit; Lertrat, Kamol; Pinlaor, Somchai

doi:10.1016/j.fct.2014.09.021

Cited by 24 publications

(17 citation statements)

References 42 publications

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“…For example, the combination of purple waxy corn cob and pandan leaf extract provided neuroprotective and memory-enhancing effects in menopause [13]. Moreover, an anthocyanin complex from purple waxy corn cobs and petals of blue butterfly pea can be anti-inflammatory, inhibit oxidative stress, reduce liver injury and periductal fibrosis, and it can be a chemopreventive agent to prevent cholangiocarcinoma caused by Opisthorchis viverrini infection [14,15].…”

Section: Introductionmentioning

confidence: 99%

Variability in Anthocyanins, Phenolic Compounds and Antioxidant Capacity in the Tassels of Collected Waxy Corn Germplasm

et al. 2019

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Corn tassel is a valuable co-product and an excellent source of phytochemicals with bioactive properties. The information on the genetic diversity in the tassel properties of waxy corn germplasm is important for creating new varieties that can have the potential for the commercial production of tassels as a co-product. Therefore, the objective of this study was to evaluate the potential of corn tassels in a set of waxy corn germplasm for the extraction of phenolic compounds with an antioxidant activity. The experiment was carried out under field conditions in the rainy season 2017 and the dry season 2017/2018. Fifty waxy corn genotypes were evaluated. Data were collected for the total anthocyanin content (TAC), total phenolic content (TPC) and the antioxidant activity was determined by the 2,2-diphenyl−1-picrylhydrazyl (DPPH) radical scavenging activity and Trolox equivalent antioxidant capacity (TEAC) assays. The season (S) had small effect on all of the parameters, accounting for 0.2–8.7% of the total variance. The genotype (G) was the largest variance component in the TAC and DPPH radical scavenging activity, accounting for 83.5–97.5% of the total variance. The G and S × G interaction contributed approximately equally to the total variance in the TPC and TEAC. Based on the TAC, TPC and antioxidant capacity variation, the genotypes were classified into seven groups. The tassels of corn genotypes belonging to three of these clusters (clusters E, F and G) had high levels of phytochemicals along with an antioxidant capacity. A significant correlation coefficient was found between the TAC and DPPH (r = 0.70 **). The TPC showed a moderate relationship with the DPPH and TEAC assays (r = 0.60 ** and 0.76 **, respectively). The information obtained from this study can be used for germplasm management and waxy corn breeding for enhancing levels of bioactive properties in waxy corn tassels.

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Section: Introductionmentioning

confidence: 99%

Variability in Anthocyanins, Phenolic Compounds and Antioxidant Capacity in the Tassels of Collected Waxy Corn Germplasm

et al. 2019

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“…Besides, in the treated animals there were reduced the formation of 8-oxodG (an oxidative DNA damage marker), NF-κB expression, iNOS synthesis, and oxidative stress. Contrarily, the gene expression of CAT, SOD, and GPx was increased in the treated experimental group [Intuyod et al, 2014]. pigment from black glutinous corncob; CTGF, connective tissue growth factor; PDGF, platelet-derived growth factor; BW, body weight; Bax, bcl-2-like protein 4; MDA, malondialdehyde; TAC, total antioxidant capacity; DM, dry mass.…”

Section: Other Biological Effectsmentioning

confidence: 99%

Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review

Magaña-Cerino¹,

Peniche-Pavía²,

Tiessen³

et al. 2019

Pol. J. Food Nutr. Sci.

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Different maize (Zea mays L.) varieties have been used for thousands of years as a healthy food source in Mesoamerica including pigmented maize. Maize ingestion could contribute to the reduction in the rate of non-communicable diseases and, in turn, to its function as an adjuvant in their management. These diseases are mainly associated with oxidative stress, which is characterized by a redox cell imbalance produced due to pro-oxidant molecules accumulation, inducing irreversible damages. Although the endogenous antioxidant defense system is effi cient, exogenous antioxidants are necessary to help to prevent this damage. Bioactive compounds, like anthocyanins, contained in dietary plants exert a major activity against oxidative stress. Could the maize anthocyanins play a curative, preventive or complementary role in the treatment of chronic diseases? Here, we describe the occurrence of anthocyanins from pigmented maize and their chemical structures. Furthermore, the biosynthesis, bioavailability, and stability are also summarized. Finally, many in vitro and in vivo studies of maize anthocyanins are discussed that demonstrated their nutraceutical potential, antioxidant capacity, and other biological effects. Given the importance of the biological properties of maize anthocyanins, it is necessary to understand the current knowledge and propose further research or clinical studies which allows us to better elucidate the biological mechanism of maize anthocyanins derivatives of several varieties and processes of cooking and combination with other ingredients to enhance their nutritional and health benefi ts.

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“…Hasil ini menunjukkan potensi bunga telang sebagai bahan nutrasetikal untuk perlindungan terhadap penyakit peradangan kronis dengan menekan produksi mediator pro-inflamasi yang berlebihan dari sel makrofag . Sebagai kompleks dengan sumber antosianin lain, ekstrak juga menunjukkan aktivitas antiinflamasi yang potensial (Priprem et al, 2015;Intuyod et al, 2014) Antiasma Salah satu khasiat bunga telang yang dipercaya di dalam pengobatan tradisional India adalah untuk menyembuhkan asma dan meredakan batuk. Asma merupakan gangguan inflamasi kronik pada saluran pernapasan yang dapat menyebabkan penderitanya mengalami batuk dan sesak napas.…”

Section: Aktivitas Inflamasi Secara In Vitrounclassified

“…Selain itu, antosianin juga menunjukkan sifat antivirus, antiinflamasi, antioksidan, anti-alergi, dan antimikroba, antikanker, anti-arteri aterosklerosis, anti-hipertensi, mencegah diabetes, melindungi sistem kardiovaskular dari kerusakan dan banyak manfaat kesehatan lainnya (Ghosh & Konishi, 2007;Khoo et al, 2017). Studi klinis telah menunjukkan efek menguntungkan antosianin pada manusia seperti meningkatkan kadar kolesterol HDL dan menurunkan kadar kolesterol LDL pada subyek dislipidemik, mengurangi risiko infark miokard pada wanita muda dan setengah baya, dan mengurangi risiko penyakit kardiovaskuler (Intuyod et al, 2014). 2020:1(2) Akan tetapi masih sangat sedikit studi terkait efek fungsional dari antosianin seri ternatin yang khas dimiliki oleh bunga telang.…”

Section: Antosianinunclassified

Tinjauan manfaat bunga telang (clitoria ternatea l.) bagi kesehatan manusia

Marpaung

2020

jffn

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All part of the butterfly pea (Clitoria ternatea) plant reported having a various positive effect on human health. The blue petal, in particular, shows a wide range of functional activity including as an antioxidant, antidiabetic, antiobesity, anticancer, anti-inflammatory, and antibiotic. The hydrophilic phase of butterfly pea flower extract contains flavonol glycosides, anthocyanins, flavones, flavonols, phenolic acids, and cyclotides. Meanwhile, the terpenoids, alkaloids, and fatty acids were found in the lipophilic phase of butterfly pea flower extract. The proven health benefits and the wide range of the type of bioactive compounds promote butterfly pea flower as the source of functional food and nutraceuticals. However, a series of intensive research, including the clinical trial, is still needed. ABSTRAKTelang (Clitoria ternatea) merupakan salah satu dari tanaman yang semua bagiannya memiliki manfaat fungsional bagi tubuh manusia. Bagian kelopak bunganya dilaporkan bermanfaat sebagai antioksidan, antidiabetes, antiobesitas, antikanker, antiinflamasi, antibiotik dan melindungi jaringan hati. Berbagai komponen bioaktif ditemukan pada bunga telang, baik yang bersifat lipofilik maupun hidrofilik. Di antara komponen bioaktif yang dijumpai adalah flavonol glikosida, antosianin, flavon, flavonol, asam fenolat, senyawa-senyawa terpenoid dan alkaloid, serta senyawa-senyawa peptida siklik atau siklotida. Rentang manfaat yang luas menjadikan bunga telang sebagai salah satu bahan potensial baik untuk pangan fungsional maupun nutrasetikal. Sekalipun demikian, serangkaian penelitian hingga ke tahap uji klinis masih diperlukan.

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Anti-inflammatory and anti-periductal fibrosis effects of an anthocyanin complex in Opisthorchis viverrini-infected hamsters

Cited by 24 publications

References 42 publications

Variability in Anthocyanins, Phenolic Compounds and Antioxidant Capacity in the Tassels of Collected Waxy Corn Germplasm

Variability in Anthocyanins, Phenolic Compounds and Antioxidant Capacity in the Tassels of Collected Waxy Corn Germplasm

Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review

Tinjauan manfaat bunga telang (clitoria ternatea l.) bagi kesehatan manusia

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