Anti-Inflammatory and Anti-Oxidative Effects of Isorhamnetin for Protection Against Lung Injury in a Rat Model of Heatstroke in a Dry-Heat Environment

Dong, Xiang Da; Li, Jiajia; Ma, Ning; Liu, Aizhong; Liu, Jiangwei

doi:10.12659/msm.935426

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Patients mainly present with acute lung injury (ALI), accompanied by pulmonary edema, pulmonary hemorrhage, pleural effusion, and exudation of inflammatory cells and cytokines (150,176,177). ALI was also found in mouse and rat models of heatstroke (21,99,158,(177)(178)(179)(180)(181)(182)(183). Rhabdomyolysis is more common in patients with EHS, and several possible mechanisms cause such phenomenon (3,166,(184)(185)(186)(187)(188)(189)(190)(191)(192)(193).…”

Section: Tissue Injury Responsesmentioning

confidence: 99%

ZBP1 and heatstroke

Deng²,

He³

et al. 2023

Front. Immunol.

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Heatstroke, which is associated with circulatory failure and multiple organ dysfunction, is a heat stress-induced life-threatening condition characterized by a raised core body temperature and central nervous system dysfunction. As global warming continues to worsen, heatstroke is expected to become the leading cause of death globally. Despite the severity of this condition, the detailed mechanisms that underlie the pathogenesis of heatstroke still remain largely unknown. Z-DNA-binding protein 1 (ZBP1), also referred to as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, was initially identified as a tumor-associated and interferon (IFN)-inducible protein, but has recently been reported to be a Z-nucleic acid sensor that regulates cell death and inflammation; however, its biological function is not yet fully understood. In the present study, a brief review of the main regulators is presented, in which the Z-nucleic acid sensor ZBP1 was identified to be a significant factor in regulating the pathological characteristics of heatstroke through ZBP1-dependent signaling. Thus, the lethal mechanism of heatstroke is revealed, in addition to a second function of ZBP1 other than as a nucleic acid sensor.

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Section: Tissue Injury Responsesmentioning

confidence: 99%

ZBP1 and heatstroke

Deng²,

He³

et al. 2023

Front. Immunol.

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“…This failure leads to a dangerous elevation in core body temperature (Tcore), surpassing 40.6 • C, which in turn can cause central nervous system dysfunction, manifesting as delirium, convulsions, and coma. As a severe condition resulting from internal thermal injury, heatstroke presents a significant life-threatening risk and is associated with a notably high mortality rate (1,2).…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes, and practices among the general community population toward heatstroke

Xu,

Chen,

et al. 2024

Front. Public Health

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Background and objectiveHeatstroke (HS) is a life-threatening condition resulting from thermal injury within the body, and it is associated with a significantly high mortality rate. This study aimed to assess the knowledge, attitudes and practices (KAP) among the general community population toward heatstroke.MethodsThe web-based cross-sectional study was conducted between September 2023 and October 2023 at the Emergency Department of Dongyang People's Hospital. A self-designed questionnaire was developed to collect demographic information of the general community population and to assess their knowledge, attitudes and practices toward heatstroke.ResultsA total of 1,356 valid questionnaires were collected. Among the participants, 875 (64.53%) were female, and 496 (36.58%) had regular exercise. The mean knowledge, attitudes and practices scores were 12.73 ± 1.42 (possible range: 0–14), 33.74 ± 2.91 (possible range: 8–40) and 34.65 ± 5.30 (possible range: 8–40), respectively. The structural equation model demonstrated that education had direct effects on knowledge (β = 0.017, p < 0.001), attitudes (β = 0.123, p < 0.001), and practices (β = −0.094, p < 0.001). Moreover, knowledge had direct effects on attitudes (β = 1.920, p < 0.001), and attitudes had direct effects on practices (β = 0.642, p < 0.001).ConclusionThe findings revealed that the general community population have sufficient knowledge, active attitudes and proactive practices toward the heatstroke. However, there is still room for improvement and it is necessary to develop and implement educational initiatives and interventions designed to further enhance their KAP toward heatstroke.

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“…Isorhamnetin (IRh), extracted from various plants including Hippophae rhamnoides L., Ginkgo biloba L., and Tamarix ramosissima, is a flavonoid-based substance and a direct metabolite of quercetin in mammals [12]. Numerous investigations have shown that IRh has exceptional anticancer, antioxidant, cardiovascular, and cerebrovascular protective properties [12][13][14][15][16]. According to recent research, IRh has also shown anti-inflammatory and immunomodulatory properties.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms and Effects of Isorhamnetin on Imiquimod-Induced Psoriasiform Dermatitis in Mice

Lin

Chen

et al. 2022

Life

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Isorhamnetin (IRh), which has a wide range of pharmacological effects, is one of the most significant active components in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L. It protects the heart and brain, in addition to possessing anti-tumor, anti-inflammatory, antioxidant, organ protection, and anti-obesity properties. We sought to assess IRh’s anti-psoriatic activity, explore its immunomodulatory properties in reducing the severity of psoriatic symptoms, and evaluate its potential immunotherapeutic effects. We used IRh to treat imiquimod (IMQ)-induced psoriasis in BALB/C mice and examined the underlying mechanisms. The outcomes demonstrated that IRh reduced epidermal hyperplasia, lowered PASI scores, and improved histopathological psoriasiform lesions in IMQ-induced mice. IRh attenuated the accumulation of malondialdehyde (MDA), and also reversed the reduction caused by IMQ of superoxide dismutase (SOD) and catalase (CAT) in skin tissues. Additionally, IRh effectively inhibited IMQ’s ability to increase proinflammatory cytokines such as TNF-α, IL-6, IL-17A, and transcription factor NF-κB. Furthermore, IRh significantly reduced the percentage of Th1 and Th17 in the spleens of mice treated with IMQ and suppressed the maturation of splenic dendritic cells. Overall, our research suggests that IRh protects against oxidative stress and inflammation in the pathogenesis of psoriasis, with potential for the development of new and potent medication for the treatment of psoriasis.

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Anti-Inflammatory and Anti-Oxidative Effects of Isorhamnetin for Protection Against Lung Injury in a Rat Model of Heatstroke in a Dry-Heat Environment

Cited by 5 publications

References 39 publications

ZBP1 and heatstroke

ZBP1 and heatstroke

Knowledge, attitudes, and practices among the general community population toward heatstroke

Mechanisms and Effects of Isorhamnetin on Imiquimod-Induced Psoriasiform Dermatitis in Mice

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