Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells

Vuong, Linh Dieu; Nguyen, Quang Ngoc; Truong, Van-Long

doi:10.1080/08923973.2019.1569049

Cited by 24 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of them can inhibit the activation of the LPS-induced NF-κB signaling pathway to reduce the inflammatory response, including tretinoin (Austenaa et al, 2009), stearidonic acid (Sung et al, 2017), caffeic acid (Kim et al, 2014), tyrosol (Lu et al, 2013), aspirin (Liu et al, 2017), 4-hydroxy-2-nonenal (Kim et al, 2009). Resveratrol (Bigagli et al, 2017), chloral hydrate (Cai et al, 2016) and paracetamol (Vuong et al, 2019) have antiinflammatory and anti-oxidant effects in LPS-stimulated RAW 264.7 macrophage cells in vitro. Calcitriol, the active form of vitamin D, has been confirmed that it can reduce the infiltration of inflammatory cells and attenuate the elevation of TNF-α during LPS-induced acute lung injury in mice (Tan et al, 2016).…”

Section: Research Articlementioning

confidence: 99%

Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening

Zhang

Zhao³

et al. 2020

Protein Cell

171

178

View full text Add to dashboard Cite

Fecal microbiota transplantation (FMT) by manual preparation has been applied to treat diseases for thousands of years. However, this method still endures safety risks and challenges the psychological endurance and acceptance of doctors, patients and donors. Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events. This washing preparation makes delivering a precise dose of the enriched microbiota feasible, instead of using the weight of stool. Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration. The toxic reactions that include death, the change in the level of peripheral white blood cells, and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted. The metagenomic next-generation sequencing (NGS) indicated the increasing types and amount of viruses could be washed out during the washing process. Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4, corticosterone, and prostaglandin G2 could be removed by repeated washing. Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess. In conclusion, this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation (WMT) is safer, more precise and more quality-controllable than the crude FMT by manual.

show abstract

Section: Research Articlementioning

confidence: 99%

Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening

Zhang

Zhao³

et al. 2020

Protein Cell

171

178

View full text Add to dashboard Cite

show abstract

“…As an example, sulforaphane protects against acetaminophen‐induced hepatotoxicity [59 ]. Its anti‐oxidant and anti‐inflammatory activity may be enhanced in vitro by combining it with some medications used in COVID‐19 such as acetaminophen [60 ]. Moreover, other mechanisms such as lipid rafts, autophagy, the fatty acid transporter CD36 and adipokines may play an equally important role.…”

Section: Introductionmentioning

confidence: 99%

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Bousquet

Cristol

Czarlewski³

et al. 2020

Clin Transl Allergy

View full text Add to dashboard Cite

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.

show abstract

“…Sulforaphane (SFN) is abundant in cruciferous plants and is a phytochemical of isothiocyanates [ 131 ]. SFN has antioxidant, anti-inflammatory, and anticancer properties [ 132 ] and is widely known as an activator of Nrf2, a key regulator of cellular redox balance [ 133 ]. SFN promoted Nrf2 expression and Nrf2-mediated cytoprotective response in both p53-wildtype (WT) and p53-knockout (KO) human colon cancer cells in a biphasic manner [ 134 ].…”

Section: Regulation Of Nrf2/keap1 By Phytochemicals In Colorectal Cancermentioning

confidence: 99%

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals

2021

View full text Add to dashboard Cite

Colorectal cancer still has a high incidence and mortality rate, according to a report from the American Cancer Society. Colorectal cancer has a high prevalence in patients with inflammatory bowel disease. Oxidative stress, including reactive oxygen species (ROS) and lipid peroxidation, has been known to cause inflammatory diseases and malignant disorders. In particular, the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) pathway is well known to protect cells from oxidative stress and inflammation. Nrf2 was first found in the homolog of the hematopoietic transcription factor p45 NF-E2, and the transcription factor Nrf2 is a member of the Cap ‘N’ Collar family. KEAP1 is well known as a negative regulator that rapidly degrades Nrf2 through the proteasome system. A range of evidence has shown that consumption of phytochemicals has a preventive or inhibitory effect on cancer progression or proliferation, depending on the stage of colorectal cancer. Therefore, the discovery of phytochemicals regulating the Nrf2/KEAP1 axis and verification of their efficacy have attracted scientific attention. In this review, we summarize the role of oxidative stress and the Nrf2/KEAP1 signaling pathway in colorectal cancer, and the possible utility of phytochemicals with respect to the regulation of the Nrf2/KEAP1 axis in colorectal cancer.

show abstract

Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells

Cited by 24 publications

References 31 publications

Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening

Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals

Contact Info

Product

Resources

About