Anti‐inflammatory and anti‐insulin resistance activities of aqueous extract from <i>Anoectochilus burmannicus</i>

Budluang, Phatcharaporn; Pitchakarn, Pornsiri; Ting, Pisamai; Temviriyanukul, Piya; Wongnoppawich, Ariyaphong; Imsumran, Arisa

doi:10.1002/fsn3.416

Cited by 20 publications

(21 citation statements)

References 75 publications

(111 reference statements)

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“…The mutagenic evaluation of FS, RS, FL, and RL is shown in Table . The reference mutagen, urethane, noticeably provoked mutant spots compared to negative control (26‐fold greater than the negative control), which is consistent with previous studies (Budluang et al., ; Pitchakarn et al., ). Furthermore, the highest concentration of all tested Inca peanut samples did not increase the incidence of total mutant spots compared to urethane after statistical analysis.…”

Section: Resultssupporting

confidence: 90%

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Safety assessment of Plukenetia volubilis (Inca peanut) seeds, leaves, and their products

Srichamnong

Ting

Pitchakarn

et al. 2018

Food Science & Nutrition

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Plukenetia volubilis or Inca peanut is a promising plant with high economic value. Its seeds can be pressed for oil production or roasted and served as a snack, while the dried leaves can be used to make a kind of tea. Although the oil from the cold‐pressed seeds has been proven to be safe for human consumption, little information is known about the other parts of the plant regarding safety. Thus, the aim of this study was to investigate the naturally occurring phytotoxins, including saponins, total alkaloids, and lectins in fresh and roasted Inca peanut seeds and leaves. In addition, cytotoxicity on several normal cell types including human peripheral blood mononuclear cells, human embryonic kidney cells, human hepatic stellate cells, and mouse fibroblasts as well as in vivo mutagenic properties was studied. This study showed that fresh Inca peanut seeds and leaves contain saponins, alkaloids, and lectins. However, roasting enables the reduction in alkaloids, saponins, and possibly lectins, suggesting that these phytotoxins become unstable under heat. Furthermore, Inca peanut seeds and leaves, especially after roasting, are safe to a variety of normal cell lines and do not induce DNA mutations in Drosophila expressing high biotransformation system. In conclusion, the data in this study indicated that high and chronic consumption of fresh seeds and leaves should be avoided. Heat processing should be applied before the consumption of Inca peanut seeds and leaves in order to reduce phytotoxins and potential health risks.

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Section: Resultssupporting

confidence: 90%

“…The mutagenic evaluation of FS, RS, FL, and RL is shown in Table 2. The reference mutagen, urethane, noticeably provoked mutant spots compared to negative control (26-fold greater than the negative control), which is consistent with previous studies (Budluang et al, 2017;Pitchakarn et al, 2017). Furthermore,…”

Section: In Vivo Mutagenicity Analysis In Drosophilasupporting

confidence: 91%

Safety assessment of Plukenetia volubilis (Inca peanut) seeds, leaves, and their products

Srichamnong

Ting

Pitchakarn

et al. 2018

Food Science & Nutrition

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“…The 2,2′‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulfonic acid (ABTS) radical decolorization assay was performed according to the method of Budluang et al () with modifications. Stock ABTS •+ was prepared in potassium persulfate and kept in the dark for 12–14 hr.…”

Section: Methodsmentioning

confidence: 99%

“…The 2,2 0 -azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical decolorization assay was performed according to the method of Budluang et al (2017)…”

Section: 2-diphenyl-1-picrylhydrazyl Radical Scavenging Assaymentioning

confidence: 99%

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

et al. 2018

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The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phytochemical contents in PSME were quantitatively equivalent to PSE. Rosmarinic acid was predominantly found in both extracts. Cell viability and anti‐mutagenicity testing demonstrated that PSE and PSME were biosecured and non‐genotoxic. Both extracts strongly scavenged free radicals and significantly reduced reactive oxygen species (ROS) production. The extracts drastically diminished nitric oxide (NO) production of LPS‐treated RAW 264.7 cells via iNOS mRNA expression. The expression of IL‐6 and COX‐2 were evidently inhibited by these extracts. It could be concluded that PSE and PSME clearly showed in vitro anti‐mutagenicity, antioxidant and anti‐inflammatory capacities. In particular, the by‐product perilla seed meal could be considered as a high nutritive functional food. Practical applications This study suggests that the seed meals, a by‐product from seed oil industry, can be utilized as a valuable dietary source for humans and animals. The high content of polyphenols and their bioactivities can be developed as functional foods, and excipients and fillers in pharmaceuticals and nutraceuticals production. Moreover, recycling of the by‐product seed meals should also reduce environmental and sanitary pollution.

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“…ABTS radical scavenging activity was evaluated by colorimetric assay 18 . To prepare a radical, a 1:1 (v/v) ratio of 7.5 mM ABTS (2,2 -azinobis-(3ethylbenzothiazoline-6-sulphonic acid)) was mixed with 6.6 mM potassium persulphate in water.…”

Section: Hplc Chromatographic Profile Of Tpc In Plementioning

confidence: 99%

Preventive effects of polyphenol-rich perilla leaves on oxidative stress and haemolysis

Tipsuwan¹,

Chaiwangyen²

2018

ScienceAsia

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We investigated the effect of perilla leaf extract (PLE) containing polyphenols on various biological functions including antioxidant activity, iron chelation, and red blood cell haemolysis protection. The total phenolic and flavonoid content were determined by colorimetric assay and HPLC analysis. The antioxidant activity was determined by DPPH and ABTS assay. The iron chelating effect was examined by the colorimetric method. Free radical scavenging activity was determined by haemoglobin-induced lipid peroxidation in a linoleic acid model system. Reactive oxygen species (ROS) inhibition was investigated in peripheral blood mononuclear cells. The antihaemolytic activity by AAPHinduced free radicals. The results revealed that PLE contained high levels of total phenolic compounds and total flavonoids (mainly rosmarinic acid). The IC 50 values of PLE by DPPH and ABTS radical scavenging assay were 34.3 ± 3.4 and 9.69 ± 0.14 µg/ml, respectively. The iron-binding effect of PLE was exhibited by complex formation with Fe 3+-NTA. The iron-chelating activity displayed a moderate IC 50 value of 10.1 ± 0.6 mg/ml. The PLE concentration of 200 µg/ml, significantly inhibited intracellular ROS 45%. The scavenging activity of PLE in haemoglobin-induced lipid peroxidation resulted in 27% inhibition. PLE also prevented AAPH-induced RBC haemolysis. In conclusion, PLE containing phenolic compounds plays a vital role in free radical scavenging and iron-chelating activities and subsequently prevents lipid peroxidation resulting from RBC haemolysis due to oxidative stress. Perilla products may be developed as health supplements, which could probably be used in prophylaxis and treatment of non-communicable diseases.

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Anti‐inflammatory and anti‐insulin resistance activities of aqueous extract from Anoectochilus burmannicus

Cited by 20 publications

References 75 publications

Safety assessment of Plukenetia volubilis (Inca peanut) seeds, leaves, and their products

Safety assessment of Plukenetia volubilis (Inca peanut) seeds, leaves, and their products

Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal

Preventive effects of polyphenol-rich perilla leaves on oxidative stress and haemolysis

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