Anti-inflammatory and anti-hyperuricemia properties of chicken feet cartilage: treatment on gouty arthritis animal model

Abstract

Gout is a form of inflammatory arthritis caused by the deposition of uric acid. The therapeutic approach to gout is mainly divided by the treatment of inflammation and the management of serum urate level. This study aim to investigate whether chondroitin sulfate (CS) and glucosamine in chicken feet cartilage powder (CFE) and aqueous extract (AE) are able to decrease serum urate level and inflammation in animal model of gouty arthritis. CFE and AE were evaluated in vitro for xanthine oxidase (XO) inhibition. The anti-hyperuricemic activity and liver XO inhibition were evaluated in vivo on oxonate-induced hyperuricemia rats. Anti-inflammatory property was also determined on monosodium urate (MSU) crystal-induced paw edema model. CFE and AE supplementation showed urate-lowering activity. However, both treatments were not able to inhibit in vitro and in vivo XO activity. In MSU crystal-induced mice, the levels of paw swelling and lipid peroxidation were increased; in addition, a decrease in the activities of SOD and changes in the expression of CD11b + TNF-α and CD11b + IL-6 of the spleen were demonstrated. These changes were reverted to near normal levels upon CFE and AE treatments. These results suggest that CS and glucosamine from CFE and AE show a potent therapeutic effect against gouty arthritis.

Tempuyung Leaves (Sonchus arvensis) Ameliorates Monosodium Urate Crystal-Induced Gouty Arthritis in Rats through Anti-Inflammatory Effects

“…MSU crystals further induce the conversion of pro-caspase-1 to active caspase-1, which then breaks down prointerleukin (IL)-1β into the active form, IL-1β [2]. Along with chemotaxis factors, IL-1β can activate other proinflammatory cytokines, including tumor necrosis factor (TNF)-α and nuclear factor (NF)-kB, which are very important for the initiation and spread of the inflammatory response, and contribute to bone erosion and damage [3]. Nonsteroidal anti-inflammatory drugs (naproxen and indomethacin), corticosteroids, and colchicine are currently used as first-line therapy for gouty arthritis [4].…”