Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase

Gupta, O.P.; Sing, Seema; Bani, Sarang; Sharma, Neha; Malhotra, S.; Gupta, B. K.; Banerjee, S.; Handa, S. S.

doi:10.1016/s0944-7113(00)80017-3

Cited by 99 publications

(49 citation statements)

References 5 publications

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“…These activities of the SC extract may probably be due to the presence of flavonoids in the extract, since these substances isolated from Myrtaceae species, including SC, are known to exert a potent inhibitory effect on a variety of enzymes related to cell activation and to the production of inflammatory mediators (35,36). Some isolated flavonoids possess anti-inflammatory (37), antiallergic (38) and analgesic (39) activities; however, few flavonoids from SC leaves (23,27) and flowers have been isolated or identified (40).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Brito

Lima

Ramos

et al. 2007

Braz J Med Biol Res

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Myrtaceae is a plant family widely used in folk medicine and Syzygium and Eugenia are among the most important genera. We investigated the anti-allergic properties of an aqueous leaf extract of Syzygium cumini (L.) Skeels (SC). HPLC analysis revealed that hydrolyzable tannins and flavonoids are the major components of the extract. Oral administration of SC (25-100 mg/kg) in Swiss mice (20-25 g; N = 7/group) inhibited paw edema induced by compound 48/80 (50% inhibition, 100 mg/kg; P ≤ 0.05) and, to a lesser extent, the allergic paw edema (23% inhibition, 100 mg/kg; P ≤ 0.05). SC treatment also inhibited the edema induced by histamine (58% inhibition; P ≤ 0.05) and 5-HT (52% inhibition; P ≤ 0.05) but had no effect on plateletaggregating factor-induced paw edema. SC prevented mast cell degranulation and the consequent histamine release in Wistar rat (180-200 g; N = 7/group) peritoneal mast cells (50% inhibition, 1 µg/mL; P ≤ 0.05) induced by compound 48/80. Pre-treatment of BALB/c mice (18-20 g; N = 7/group) with 100 mg/kg of the extract significantly inhibited eosinophil accumulation in allergic pleurisy (from 7.662 ± 1.524 to 1.89 ± 0.336 x 10 6 /cavity; P ≤ 0.001). This effect was related to the inhibition of IL-5 (from 70.9 ± 25.2 to 12.05 ± 7.165 pg/mL) and CCL11/eotaxin levels (from 60.4 ± 8.54 to 32.8 ± 8.4 ng/mL) in pleural lavage fluid, using ELISA. These findings demonstrate an anti-allergic effect of SC, and indicate that its anti-edematogenic effect is due to the inhibition of mast cell degranulation and of histamine and serotonin effects, whereas the inhibition of eosinophil accumulation in the allergic pleurisy model is probably due to an impairment of CCL11/eotaxin and IL-5 production.

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Section: Discussionmentioning

confidence: 99%

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Brito

Lima

Ramos

et al. 2007

Braz J Med Biol Res

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“…In the present study, silymarin significantly reduced the serum NF-κB, TNF-α, IL-1β and IL-6 levels in the lungs of I/R-injured rats. A previous study demonstrated that silymarin suppressed inflammation in mycobacterial adjuvant-induced arthritis (19) and in the skin of SENCAR mice (20). Silymarin may therefore represent a potent agent for protection against the lung I/R-induced inflammatory response.…”

mentioning

confidence: 94%

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Jin

Zhao

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Silymarin is a traditional therapeutic used to protect the liver, acting to oppose lipid peroxidation, to enhance liver regeneration and functioning as an antioxidant. However, the effects of silymarin on pulmonary vascular dysfunction have not been investigated. In the present study, the modulatory effects of silymarin on pulmonary vascular dysfunction and the underlying mechanisms behind this were investigated in a lung ischemia-reperfusion (I/R) injury rat model. Male Sprague Dawley rats were randomly divided into 3 groups, including: i) A control group (n=10); ii) an I/R group (n=10); and iii) a silymarin-treated group (n=10). All experimental rats received 250 mg/kg/day of silymarin for 8 days. Silymarin was demonstrated to markedly improve lung I/R-induced pulmonary vascular dysfunction and lung moisture. Following silymarin treatment, inflammation and oxidative stress in the lung I/R-injury rats were demonstrably suppressed. Treatment with silymarin also inhibited the activation of caspase-3 and -9, and hypoxia inducible factor-1α (HIF-1α) and inducible nitric oxide synthase (iNOS) protein expression in the lung I/R-injury rats. Silymarin was concluded to impact upon pulmonary vascular dysfunction through the HIF-1α-iNOS pathway in the lung I/R injury rat model.

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“…This action was attributed to the inhibition of enzymatic peroxidation in the lipoxygenase pathway and free radical scavenging activity (Bauman et al, 1980). Silymarin exhibited significant anti-inflammatory and antiarthritic activities in the papaya latex induced model of inflammation and mycobacterial adjuvant induced arthritis in rats (Gupta et al, 2000). This action is mediated through inhibition of 5-lipoxygenase.…”

Section: Anti-inflammatory Activitymentioning

confidence: 96%

Silymarin, Natural Flavonolignans from Milk Thistle

AbouZid¹

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase

Cited by 99 publications

References 5 publications

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

Silymarin, Natural Flavonolignans from Milk Thistle

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