Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract

Perazzo, Fábio Ferreira; Lima, Leonardo M.; Padilha, Marina de Mesquita; Rocha, Leandro; Sousa, Pergentino José da Cunha; Carvalho, J.C.T.

doi:10.1590/s0102-695x2008000300002

Cited by 17 publications

(18 citation statements)

References 30 publications

(38 reference statements)

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“…*p < 0.05 compared to the control group (ANOVA, Tukey test). willd (Perazzo et al, 2008) and Satureja hortensis L (Hajhashemi et al, 2002). Our data demonstrated that the antiinflammatory and antinociceptive activities of eugenol might be partially related to inhibition of prostaglandin synthesis or release of other endogenous mediators.…”

Section: Resultsmentioning

confidence: 70%

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Daniel¹,

Sartoretto²,

Schmidt³

et al. 2009

Rev. bras. farmacogn.

166

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RESUMO: "Atividades antiinflamatória e antinociceptiva do eugenol em modelos experimentais em animais". Eugenia caryophyllata, popularmente conhecida como "cravo-daíndia", cresce naturalmente na Indonésia e é cultivada em várias partes do mundo, incluindo o Brasil. O cravo-da-índia é utilizado em culinária, em farmácia, perfumaria e cosméticos. O óleo essencial extraído do cravo-da-índia cujo principal componente é o eugenol tem sido utilizado em odontologia como anti-séptico e analgésico. O objetivo deste estudo foi avaliar as atividades antiinflamatória e antinociceptiva do eugenol de uso odontológico, administrado oralmente, em modelos experimentais in vivo. A atividade antiinflamatória do eugenol foi avaliada através do volume de exsudato e migração leucocitária no teste de pleurisia e do edema de pata de rato induzido pela carragenina. A atividade antinociceptiva foi avaliada através dos testes de contorções induzidas pelo ácido acético e da placa quente. O eugenol (200 e 400 mg/kg) reduziu o volume de exsudato pleural sem interferir na contagem de leucócitos totais presentes na pleura. Na dose de 200 mg/kg, o eugenol inibiu significativamente o edema de pata, 2-4 h após a injeção do agente flogístico. No teste da placa quente, a administração do eugenol (100 mg/kg) mostrou atividade significativa à reação de desconforto-tempo dependente, avaliada como a latência da resposta, inibida pela meperidina. Eugenol na doses de 50, 75 e 100 mg/kg apresentou efeito antinociceptivo significativo no teste de contorções abdominais induzidas pelo ácido acético em comparação com o grupo controle. Os dados obtidos indicam que o eugenol apresenta atividade antiinflamatória e antinociceptiva periférica.Unitermos: Eugenia caryophyllata, Syzygium aromaticum, Myrtaceae, atividade antiinflamatória, atividade antinociceptiva, óleo essencial, cravo-da-índia.ABSTRACT: Eugenia caryophyllata, popular name "clove", is grown naturally in Indonesia and cultivated in many parts of the world, including Brazil. Clove is used in cooking, food processing, pharmacy; perfumery, cosmetics and the clove oil (eugenol) have been used in folk medicine for manifold conditions include use in dental care, as an antiseptic and analgesic. The objective of this study was evaluated the anti-inflammatory and antinociceptive activity of eugenol used for dentistry purposes following oral administration in animal models in vivo. The anti-inflammatory activity of eugenol was evaluated by inflammatory exudates volume and leukocytes migration in carrageenan-induced pleurisy and carrageenan-induced paw edema tests in rats. The antinociceptive activity was evaluated using the acetic acid-induced writhing and hot-plate tests in mice. Eugenol (200 and 400 mg/kg) reduced the volume of pleural exudates without changing the total blood leukocyte counts. At dose of 200 mg/kg, eugenol significantly inhibited carrageenan-induced edema, 2-4 h after injection of the flogistic agent. In the hot-plate test, eugenol administration (100 mg/kg) showed unremarkable activity agai...

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Section: Resultsmentioning

confidence: 70%

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Daniel¹,

Sartoretto²,

Schmidt³

et al. 2009

Rev. bras. farmacogn.

166

View full text Add to dashboard Cite

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“…F1 rats born to mothers exposed to EHP showed greater sensitivity to the painful inflammatory agent acetic acid, as noted in the test writhes, though this extract can decrease the production of inflammatory mediators (Albert et al, 2002;Perazzo et al, 2008). As previously discussed, exposure of the F1 animals to EHP during neurogenesis caused increased central antinociceptive response but it is proposed that this could not prevent the generation and propagation of nociceptive stimuli to the central nervous system.…”

Section: Discussionmentioning

confidence: 83%

Effect of the extract of Hypericum perforatum on neurodevelopment of regions related to pain control and convulsion

Campos¹,

Guerra²,

Peters³

et al. 2017

J. Med. Plants Res.

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Hypericum perforatum (HP) is well-known by the population of the world as herb with antidepressant effect. Its various components, such as hypericin and hyperforin, provide many other effects for this plant, for example, antinociceptive and anticonvulsant. The aim of this work was to determine whether HP administration during pregnancy can cause changes in neurodevelopment related to pain control and seizures in rats (F1). For this, Wistar rats received oral doses of HP at 36, 72 and 144 mg/kg throughout pregnancy. Tests to evaluate the antinociceptive and anticonvulsant activity of HP were performed in adult F1 rats, which showed a decrease of both responses, suggesting therefore that HP exposition during pregnancy causes changes in neurodevelopment of brain regions related to pain control and seizures in rats.

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“…7140, Italy), which consists of immersing the animal's paws into a vat containing a transducing ionic solution. The paw volume was measured directly in millimetres using a digital computer system (Perazzo et al 2008). …”

Section: Rat Paw Oedemamentioning

confidence: 99%

Anti-inflammatory and analgesic effects of 6α,7β–dihydroxy-vouacapan-17β-oic acid isolated from Pterodon emarginatus Vog. fruits

et al. 2011

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6α,7β-dihydroxy-vouacapan-17β-oic (tricyclic furanoid diterpene; DHVO) acid was isolated from the hexane extract of Pterodon emarginatus fruits and evaluated for anti-inflammatory and analgesic effects using an assay that induces paw oedema with carrageenan, dextran and prostaglandin E(2) (PGE(2)) in rats and the writhing and formalin tests in mice. Oral administration of 50 mg/kg DHVO significantly inhibited carrageenan-induced oedema formation by 24% (p < 0.05). This treatment did not inhibit dextran-induced oedema but was effective when the inflammatory effect was triggered by PGE(2), inhibiting oedema formation by 39% (p < 0.05). In the writhing test, doses of 50, 200 and 400 mg/kg resulted in a dose-dependent effect with a correlation coefficient (r) of 0.983 (F = 29.04, ANOVA). Doses of 50 and 100 mg/kg inhibited both the neurogenic and inflammatory phases (p < 0.05) in the formalin test but were not effective for increasing the lag time in the hot plate test. Together, these results suggest that DHVO has both anti-inflammatory and peripheral analgesic effects.

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Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract

Cited by 17 publications

References 30 publications

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models

Effect of the extract of Hypericum perforatum on neurodevelopment of regions related to pain control and convulsion

Anti-inflammatory and analgesic effects of 6α,7β–dihydroxy-vouacapan-17β-oic acid isolated from Pterodon emarginatus Vog. fruits

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