Anti-inflammatory and analgesic activities of a new cucurbitacin isolated from Citrullus colocynthis seeds

Marzouk, Belsem; Mahjoub, Mohamed Ali; Bouraoui, Abderrahman; Fenina, Nadia; Aouni, Mahjoub; Marzouk, Zohra

doi:10.1007/s00044-012-0406-2

Cited by 17 publications

(10 citation statements)

References 14 publications

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“…He, Yu, He, Hu, Xia and He [10] reported an increase in the mRNA abundances of HSP-70 in the spleen of heat-stressed yellow-feather broilers associated with increased TNF-α among other pro-inflammatory cytokines. In rat model study, it was found that CCs fractions possess anti-inflammation properties [23]. In the present study, the significant reduction in TNF-α observed with CCs supplementation can justify the associated reduction in the HSP-70 protein expression.…”

Section: Discussionsupporting

confidence: 47%

“…Ten bioactive compounds were characterized in CC seeds, including quinic acid, isovitexin, scoparin, vitexin-2"-O-rhamnoside, reserpine, digitoxin, triprolidine, naringenin, linoleic acid, and oleic acid [22]. Anti-inflammation properties of CC seeds fractions have been reported [23][24][25] as well as anti-microbial potentials [26]. Normal growth performance was achieved in broilers fed a diet containing whole CC seeds up to 15% [27] and with no toxicity effect of their oil [28].…”

Section: Introductionmentioning

confidence: 99%

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Citrullus colocynthis Seeds: A Potential Natural Immune Modulator Source for Broiler Reared under Chronic Heat Stress

Alzarah

Althobiati

Abbas

et al. 2021

Animals

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There is an extensive search for natural products that can be introduced to broiler rations to improve performance, especially during the unfavorable breeding conditions. Under heat-stress conditions, the immune response seriously deteriorates, which consequently impairs broiler production performance. Thus, the present study aimed to investigate the potentials of Citrullus colocynthis seeds (CCs) supplementation to modulate the immune response of broilers subjected to chronic heat stress. A total of 300 Cobb-500 male broiler chickens aged 21 days were randomly divided into two equal groups and reared under either thermo-neutral condition (24 ± 1 °C) or subjected to cyclic heat stress (34 ± 1 °C for 8 h). Each group was further divided into two groups (5 replicate × 15 chicks) and was fed either the basal diet or the basal diet with 0.1% CCs supplementation. The results showed that heat stress impaired the production performance by lowering the final body weight and feed intake as well as impairing feed conversion. The levels of stress markers (i.e., malondialdehyde, tumor necrosis factor-α and corticosterone) increased (p < 0.05), whereas the activity of antioxidant enzymes decreased in broilers exposed to heat stress. Further, heat stress caused direct suppression of broiler humoral and cell-mediated immune responses. The stimulating index of T and B lymphocytes proliferation, as well as the antibody titer against sheep red blood cells, were significantly (p < 0.05) reduced by heat-stress exposure. However, CCs supplementation to broilers subjected to heat stress improved (p < 0.05) the final body weight, feed intake, and feed conversion ratio (FCR), compared to the non-supplemented stressed group. The cellular and cell-mediated immune response indicators significantly enhanced (p < 0.05) with CCs supplementation. Supplementation of CCs to broilers reared under similar environmental conditions elevated the total white blood cells (TWBCs) count and the broiler stimulating index of T and B lymphocytes. It can be concluded that CC seeds can be effectively used to stimulate the immune response and improve the production performance of broilers reared under heat-stress condition.

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Citrullus colocynthis Seeds: A Potential Natural Immune Modulator Source for Broiler Reared under Chronic Heat Stress

Alzarah

Althobiati

Abbas

et al. 2021

Animals

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“…The leaves and fruits are rich sources of bio-active compounds such as cucurbitacins Ghane, 2018, 2019;Chanda et al, 2019) which have various health benefits such as antioxidant, antidiabetic, anti-tumor, anti-proliferrative and antimicrobial properties (Marzouk et al, 2012;Ma et al, 2014;Ku et al, 2017;Attar and Ghane, 2019). The contents of cucubitacins type E and I have been quantified in leaves (Mashilo et al, 2018;Chanda et al, 2019).…”

Section: Nutritional and Anti-nutritional Compositionsmentioning

confidence: 99%

Progress on Genetic Improvement and Analysis of Bottle Gourd [Lagenaria siceraria (Molina) Standl.] for Agronomic Traits, Nutrient Compositions, and Stress Tolerance: A Review

Mkhize

Mashilo

Shimelis

2021

Front. Sustain. Food Syst.

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Bottle gourd [Lagenaria siceraria (Molina) Standl.] is an important multi-purpose cucurbit crop grown for its leaf, fruit, and seed. It is widely cultivated and used for human consumption in sub-Saharan Africa (SSA) providing vital human nutrition and serving as food security crop. There is wide genetic variation among bottle gourd genetic resources in Africa for diverse qualitative and quantitative attributes for effective variety design, product development, and marketing. However, the crop is under- researched and -utilized, and improved varieties are yet to be developed and commercialized in the region. Therefore, the objective of this review is to provide the progress on bottle gourd genetic improvement and genetic analysis targeting agronomic and horticultural attributes, nutritional composition, biotic, and abiotic stress tolerance to guide current and future cultivar development, germplasm access, and conservation in SSA. The first section of the paper presents progress on breeding of bottle gourd for horticultural traits, agronomic performance, nutritional and anti-nutritional composition, and biotic and abiotic stress tolerance. This is followed by important highlights on key genetic resources of cultivated and wild bottle gourd for demand driven breeding. Lastly, the review summaries advances in bottle gourd genomics, genetic engineering and genome editing. Information presented in this paper should aid bottle gourd breeders and agronomists to develop and deploy new generation and promising varieties with farmer- and market -preferred attributes.

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“…The main bioactive chemical components in the chloroform part of CCS extracts came from the separation and characterization of glycoside 11-deoxycucurbitacinI2ObD at the doses of 0.5 and 1 mg/kg body weight in two animal models. The compounds studied demonstrated strong analgesic and anti-inflammatory effects in two animal models ( Marzouk et al, 2013 ). The in vivo analgesic and anti-inflammatory actions of organic extracts of unripe fruits and seeds of Tunisian melon were studied.…”

Section: Pharmacological Effects Of C Colocynthismentioning

confidence: 99%

Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising Traditional Uses, Pharmacological Effects, Aspects, and Potential Applications

Munawar

Saeed

et al. 2022

Front. Pharmacol.

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Health consciousness and increased knowledge about the side effects of synthetic drugs have enhanced interest in traditional medicines. Medicinal plants offer cures for various diseases, leading to improved living standards. This has brought ethnomedicinal studies into the spotlight and increased demand for herb-based medicines. Citrullus colocynthis is an herbaceous plant containing an abundance of nutrients that play a key role in the improvement of wellbeing. C. colocynthis has many biological properties, such as antioxidative, hypoglycemic, antibacterial, anti-cancerous, anti-inflammatory, analgesic, gastrointestinal tract, reproduction, protection, anti-microbial, antidiabetic, hypolipidemic, antineoplastic, profibrinolytic, anti-allergic, pesticidal, and immune-stimulatory. There are numerous bioactive compounds like cucurbitacin, flavonoids, and polyphenols in C. colocynthis that give it medicinal properties. Herein, we have extensively compiled, reviewed, and analyzed significant information on C. colocynthhis from the best published available evidence in PubMed, Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, and Google Scholar, etc. Scientific literature evidenced that owing to the bioactive constituents, including cucurbitacin, polyphenols, flavonoids, and other potent molecules, C. colocynthis has many pharmacological and physiological functions. It possesses multi-beneficial applications in treating various disorders of humans and animals. So, the primary purpose of this comprehensive review is to provide an overview of the findings of positive impacts and risks of C. colocynthis consumption on human health, especially in poultry and veterinary fields. In the future, this narrative article will be aware of discoveries about the potential of this promising natural fruit and its bioactive compounds as the best nutraceuticals and therapeutic drugs in veterinary and human medicine.

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Anti-inflammatory and analgesic activities of a new cucurbitacin isolated from Citrullus colocynthis seeds

Cited by 17 publications

References 14 publications

Citrullus colocynthis Seeds: A Potential Natural Immune Modulator Source for Broiler Reared under Chronic Heat Stress

Citrullus colocynthis Seeds: A Potential Natural Immune Modulator Source for Broiler Reared under Chronic Heat Stress

Progress on Genetic Improvement and Analysis of Bottle Gourd [Lagenaria siceraria (Molina) Standl.] for Agronomic Traits, Nutrient Compositions, and Stress Tolerance: A Review

Citrullus colocynthis (L.) Schrad (Bitter Apple Fruit): Promising Traditional Uses, Pharmacological Effects, Aspects, and Potential Applications

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