Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems

Shaheen, Nazma; Azam, A.T.M. Zafrul; Anwar, Saeed; Parvez, Sorwer Alam; Punyamurtula, Ujwal; Hasan, Md. Kamrul

doi:10.1186/s42269-022-00708-0

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Additionally, NS may protect against neurodegenerative conditions such as Alzheimer's [15] and Parkinson's disease [16]. Pertinent to the present study, NS has repetitively exhibited anti-oxidative and anti-inflammatory properties [17][18][19][20][21], reducing the symptoms of headaches, menstrual cramps, and arthritis [22] and boosting immunity [23,24]. Several studies reported NS, and its active component thymoquinone, to reduce levels of pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrosis factor (TNF)-α [3,[25][26][27][28][29].…”

Section: Introductionsupporting

confidence: 61%

Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats

Uzzan,

Rostevanov,

Rubin

et al. 2024

IJMS

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Nigella sativa (NS) is a native herb consumed habitually in several countries worldwide, possessing manifold therapeutic properties. Among them, anti-inflammatory features have been reported, presumably relating to mechanisms involved in the nuclear factor kappa-B pathway, among others. Given the observed association between neuroimmune factors and mental illness, the primary aim of the present study was to examine the effects of chronic NS use on manic-like behavior in rats, as well as analyze levels of brain inflammatory mediators following NS intake. Using male and female rats, baseline tests were performed; thereafter, rats were fed either regular food (control) or NS-containing food (treatment) for four weeks. Following intervention, behavioral tests were induced (an open field test, sucrose consumption test, three-chamber sociality test, and amphetamine-induced hyperactivity test). Subsequently, brain samples were extracted, and inflammatory mediators were evaluated, including interleukin-6, leukotriene B4, prostaglandin E2, tumor necrosis factor-α, and nuclear phosphorylated-p65. Our findings show NS to result in a marked antimanic-like effect, in tandem with a positive modulation of select inflammatory mediators among male and female rats. The findings reinforce the proposed therapeutic advantages relating to NS ingestion.

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Section: Introductionsupporting

confidence: 61%

Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats

Uzzan,

Rostevanov,

Rubin

et al. 2024

IJMS

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“…For headache and body pain, seeds of Nigella sativa, cloves of Allium sativum, and leaves of Centella asiatica are crushed together to obtain juice, which is then massaged onto painful areas. Analgesic and anti-inflammatory activities of Nigella sativa (black cumin) seeds have been demonstrated in acetic acid-induced writhing tests and carrageenan-induced rat paw edema [57] . A constituent of the seeds, thymoquinone, has been shown responsible for these two effects among others [58] .…”

Section: Resultsmentioning

confidence: 99%

A collection of home remedies used in Dhaka city, Bangladesh

Jahan¹,

Bashar²,

Swachho³

et al. 2023

J. Med. Plants Stud.

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Background: Home remedies were possibly used by human beings since their advent. Even in the modern era, home remedies may form the only recourse for people in rural and urban Bangladesh, who either cannot afford conventional treatment or live in remote areas from where transport to a modern hospital is practically not possible in time. As a result, from time immemorial, home remedies have formed a practical feature of the medical landscape in Bangladesh. The objective of this study was to gather information from households in Dhaka city regarding their use of home remedies. Methods and findings: Information was collected from households comprising of friends, relatives, and household workers through snowball sampling. Together they formed a wide spectrum of people of varying income but mostly on the low income side, that is earning less than Bangladesh Taka (BDT) 30,000 per month (1 US$ = BDT107.24). All collected information were given voluntarily by the households surveyed and duplicate information was discarded. The main question asked was as to what home remedies ('totka chikitsha' in Bengali) were used, if any. As far as possible, detailed descriptions were taken about the formulations, diseases, and dosages. Plants named by the people were common plants and easily identified from their Bengali names. Conclusions: Interestingly, most plants used as home remedies were either cultivated plants and easily obtained in the kitchen markets of Dhaka city or could be found by roadsides and outskirts of the city on fallow lands. Despite their uses by the common people, a scientific perusal of the literature suggests that they can form a real remedial recourse for people when no better treatment modes are affordable or nearby. Furthermore, the plants used can be found all throughout Bangladesh making them readily available items for treatment.

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“…Furthermore, NSE markedly inhibited inflammation and hepatocyte apoptosis via PPARγ influenced modulation of JAK2/STAT3 and Bcl-2/Bax/Caspase-9 signaling pathways, suggesting a possible hepatoprotective role of NSE. NSE, rich in polyphenols such as quercetin, gallic acid, chlorogenic acid, m-coumeric acid, ferulic acid and sinapic acid, has been recognized for antioxidative [37,38], analgesic [39], anti-inflammatory, immunomodulatory [16,19] and anticancer [40] activities. Therefore, NSE was tested for its hepatoprotective effectiveness in this study.…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa L. Attenuates Oxidative Stress, Inflammation and Apoptosis in Concanavalin A-induced Acute Immunological Liver Damage in Mice

Mushtaq,

Aslam,

Faisal

et al. 2024

Braz. arch. biol. technol.

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Liver's contribution to innate immunity is eminent. However, uncontrolled inflammatory conditions predispose the liver to immune-mediated injury. Nigella sativa L. is traditionally implicated in infectious, inflammatory, metabolic and hepatorenal complications. This study aimed to evaluate the protective role of N. sativa seed extract (NSE) against concanavalin A (ConA)-induced acute immunological liver injury in mice. In vitro, NSE was subjected to quantitative phytochemical characterization and 1,1-diphenyl-2-picryhydrazyl (DPPH) analysis. In vivo, male Balb/c mice were pretreated with NSE (100, 200 and 400 mg/kg/day, p.o.) and pioglitazone (5 mg/kg/day, p.o.) for seven consecutive days. A single dose of ConA (12 mg/kg, i.v.) was injected and samples were collected for biochemical, histopathological and qRT-PCR analyses after 8 h of ConA injection. In vitro analysis showed considerable quantities of polyphenols and significant DPPH scavenging ability of NSE. In mice, ConA resulted in a significant (p<0.05) increase in liver injury markers (ALT, AST, ALP and TBil) and hepatic oxidative stress (SOD, CAT and MDA). Also, a substantial elevation of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in liver tissues was noticed. Furthermore, ConA HIGHLIGHTS• Nigella sativa seed extract (NSE) possess significant polyphenol contents and antioxidant potential.• NSE attenuated concanavalin A-induced liver injury and oxidative stress.• NSE suppressed liver inflammation through modulating PPARγ/JAK2/STAT3 pathway.• NSE inhibited hepatocyte apoptosis via downregulating Bcl-2/Bax/Caspase-9 pathway.

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Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems

Cited by 6 publications

References 39 publications

Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats

Chronic Treatment with Nigella sativa Oil Exerts Antimanic Properties and Reduces Brain Inflammation in Rats

A collection of home remedies used in Dhaka city, Bangladesh

Nigella sativa L. Attenuates Oxidative Stress, Inflammation and Apoptosis in Concanavalin A-induced Acute Immunological Liver Damage in Mice

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