Anti-inflammatory activity of the Fruits of Blue Honeysuckle

Hwa, Kim Jeong; 조미나,; 한주환,; 표승현,; 김태수,; 김은희,; Lee, Jaekwon

doi:10.17480/psk.2016.60.5.235

Cited by 3 publications

(6 citation statements)

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“…국내에서는 강 원도와 함경도, 그리고 한라산 능선 지역에서 생산되고 있 다. 댕댕이나무에 관한 연구로는 항산화 활성 및 성분 분 석에 대한 연구가 진행 되었고 [8,9] 알코올성 손상 간기능 개선 효과에 대한 연구 [10] 면역 [11], 항암 [12]등에 효과 적이며 특히 항산화 효과는 방사선 치료 시 회복에 도움을 주는 것으로 보고되었다 [13,14]…”

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Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)

Park

Lee

2019

J Nutr Health

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Purpose: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes, cardiovascular diseases, and cancer. Lonicera caerulea (LC) originates from high mountains or wet areas and has been used as a traditional medicine in northern Russia, China, and Japan. LC contains a range of bioactive constituents, such as vitamins, minerals, and polyphenols. This study examined the anti-obesity effects of LC during differentiation in preadipocytes. Methods: The cell viability assay was performed after the differentiation of 3T3-L1 cells for 7 days. Oil Red O staining was used to visualize the changes in lipid droplets in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs). The mRNA expression of obesity-related genes was determined by quantitative real-time PCR. Results: According to the results of Oil Red O staining, the lipid levels and size of lipid droplets in the adipocytes were reduced and the LC extract (LCE, 0.25-1 mg/mL) markedly inhibited adipogenesis in a dose-dependent manner. The treatment of LCE also decreased the mRNA expression of peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein-α (C/EBPα), and sterol regulatory element binding protein 1 (SREBP1) in 3T3-L1 cells. Western blot analysis showed that the PPARγ, C/EBPα, and SREBP1 protein levels in both 3T3-L1 and MADSC were reduced in a dose-dependent manner. Conclusion: These results suggest that LCE can inhibit adipogenic differentiation through the regulation of adipogenesis-related markers.

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Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)

Park

Lee

2019

J Nutr Health

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“…The cortex and leaves of P. densiflora were extracted with MeOH. Following ioassay-guided fractionation, the EtOAc and n-BuOH soluble fractions were then fractionated and purified by column chromatography and preparative HPLC, resulting in the isolation of 26 compounds, including two new megastigmane-type compounds (1 and 2), 21 diterpenoids (3-23), and three flavonoids (24)(25)(26).…”

Section: Isolation and Structural Elucidation Of Compounds Isolated F...mentioning

confidence: 99%

“…However, to the best of our knowledge, there have been limited studies evaluating the antiviral properties of P. densiflora, especially against influenza A at the compound level. Regarding its chemical components, essential oils (0.3-1.3%, antioxidant and antiaging) including α-pinene, β-pinene, camphene, limonene, borneol (6.8%), bornyl acetate (3.8%), along with cinnamic acid, benzoic acid, flavonoids, abietane diterpenoid, and stilbenoid (antibacterial and antifungal) have been reported from its leaves [20,[25][26][27]. It has been reported that the pine cones that contain labdane-type diterpenoids that have inhibitory activity against acne [28].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activities of Compounds Isolated from Pinus densiflora (Pine Tree) against the Influenza A Virus

Lee

Nguyen

et al. 2020

Biomolecules

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Pinus densiflora was screened in an ongoing project to discover anti-influenza candidates from natural products. An extensive phytochemical investigation provided 26 compounds, including two new megastigmane glycosides (1 and 2), 21 diterpenoids (3–23), and three flavonoids (24–26). The chemical structures were elucidated by a series of chemical reactions, including modified Mosher’s analysis and various spectroscopic measurements such as LC/MS and 1D- and 2D-NMR. The anti-influenza A activities of all isolates were screened by cytopathic effect (CPE) inhibition assays and neuraminidase (NA) inhibition assays. Ten candidates were selected, and detailed mechanistic studies were performed by various assays, such as Western blot, immunofluorescence, real-time PCR and flow cytometry. Compound 5 exerted its antiviral activity not by direct neutralizing virion surface proteins, such as HA, but by inhibiting the expression of viral mRNA. In contrast, compound 24 showed NA inhibitory activity in a noncompetitive manner with little effect on viral mRNA expression. Interestingly, both compounds 5 and 24 were shown to inhibit nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in a dose-dependent manner. Taken together, these results provide not only the chemical profiling of P. densiflora but also anti-influenza A candidates.

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“…The P. densiflora essential oils' chemical components in leaves and twigs are similar. However, the component α-pinene is the most abundant in leaf essential oils, while β-pinene is predominantly found in the essential oils extracted from twigs [30]. Unlike essential oils from the leaves and twigs of P. densiflora, the major chemical component of wood essential oils is longifolene (14.3%) [24].…”

Section: Investigating the Selected Pinaceae And Cupressaceae For Ess...mentioning

confidence: 99%

“…P. densiflora leaf essential oils showed antioxidant and anti-ageing activity owing to phellandrene and B-pinene. So, it could be used as a functional cosmetic ingredient for anti-wrinkle benefits [30]. Furthermore, essential oils contain anti-proliferative, antisurvival, and pro-apoptotic effects on human oral squamous cells because of α-pinene, leading to the cytotoxic effect [31].…”

Section: Investigating the Selected Pinaceae And Cupressaceae For Ess...mentioning

confidence: 99%

Development of Pinaceae and Cupressaceae Essential Oils from Forest Waste in South Korea

Park,

Woo,

Park

2023

Plants

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The growing awareness of environmental issues has garnered increasing interest in the use of waste material in a wide variety of applications. From this viewpoint, developing essential oils from forest waste can bring new cost opportunities for the effective and sustainable management of unused forestry biomass. However, better knowledge of the production, chemical constituents, and application of essential oils is necessary. Among the species considered to be of interest from the point of view of their essential oils and forest biomass, Pinaceae and Cupressaceae were selected in this study as potential candidates for commercial essential oils based on previous studies. This current study focuses on investigating Pinaceae (Larix kaempferi, Pinus densiflora, and Pinus koraiensis) and Cupressaceae (Chamaecyparis obtusa and Chamaecyparis pisifera) essential oils extracted from various parts from the perspective of their bioactive compounds and potential applications. This is followed by an overview of the essential oils industry in South Korea, with particular attention being paid to utilising unused forest biomass. Therefore, this is a comprehensive review suggesting that Pinaceae and Cupressaceae essential oils extracted from various parts of forest waste could be utilised in various industries, adding value to the aspect of sustainable industry. Furthermore, our study contributes towards capturing the value of forest resources through the utilisation of native essential oils in South Korea.

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Anti-inflammatory activity of the Fruits of Blue Honeysuckle

Cited by 3 publications

References 0 publications

Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)

Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)

Antiviral Activities of Compounds Isolated from Pinus densiflora (Pine Tree) against the Influenza A Virus

Development of Pinaceae and Cupressaceae Essential Oils from Forest Waste in South Korea

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