Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae)

Abstract

Over the years, medicinal plants have been employed in the treatment of inflammation and related ailments. This study evaluated the anti-inflammatory potential of the aerial parts of S. brevipes. The extracts and fractions were further evaluated for anti-inflammatory activity in carrageenan-induced rat model at varying doses (200 and 400 mg/kg doses, orally) for 5 h of treatment. The result of the phytochemical screening showed the presence of alkaloids, terpenoids, glycosides, flavonoids and tannins in the aerial parts of the plant. The in vivo anti-inflammatory study exhibited inhibition of 42% and 44%, 47% and 36%, 33% and 31%, and 43% and 42% for methanol extract n-hexane fraction, ethyl acetate fraction, and methanol fraction, at 200 and 400 mg/kg doses, respectively. The positive control (diclofenac sodium) showed an inhibition value of 51% at 5 mg/kg dose. Finally, it is concluded that S. brevipes possesses anti-inflammatory potential which validates the enthnomedicinal claim of the plant.

IN-VITRO NUTRITIONAL, PHYTOCHEMICAL, ANTIOXIDANT AND ANTI-INFLAMMATORY ANALYSES INDICATED DISPARITY IN Cola nitida L. and Garcinia kola Heckel USED IN NIGERIA

“…Using herbs and other plants as medicine is common among rural residents of developing and poor countries. Traditional plant treatments have been used to treat and prevent illnesses in humans for thousands of years, suggesting that they are the ancestors of today's pharmaceuticals (Khan et al, 2023;Attah et al, 2022;Apiamu et al, 2018). Even in regions where modern treatment is the norm, including the poor and industrialized nations, a deal of people still use traditional medicine (Attah et al, 2022;Apiamu et al, 2018;Himal et al, 2008).…”

“…Traditional plant treatments have been used to treat and prevent illnesses in humans for thousands of years, suggesting that they are the ancestors of today's pharmaceuticals (Khan et al, 2023;Attah et al, 2022;Apiamu et al, 2018). Even in regions where modern treatment is the norm, including the poor and industrialized nations, a deal of people still use traditional medicine (Attah et al, 2022;Apiamu et al, 2018;Himal et al, 2008). To this end, the study evaluated the phytochemical, antioxidant, free radical-scavenging capability, and antiinflammatory properties of C. nitida and G. kola Heckel nuts to establish which is more useful in traditional medicine.…”

“…Medicine, fibre, food, construction materials, and other necessities come from the aerial parts of plants, such as seeds, stems and leaves among others (Khan et al, 2023;Hussain et al, 2020;Apiamu et al, 2018;Evuen et al, 2016). Plants provide the body with minerals, salts, vitamins, and some hormone precursors in addition to protein and energy (Attah et al, 2022;Evuen et al, 2022). More than 80% of humanity relies on conventional therapies for primary healthcare, according to global report (WHO, 2011).…”