Anti-inflammatory activity of roots of Ecbolium viride (Forsk) Merrill

Lalitha, K. G.; Sethuraman, Mathur Gopalakrishnan

doi:10.1016/j.jep.2009.12.030

Cited by 24 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, based on the results of cell proliferation and migrations, these four compounds may serve as lead in the breakthrough of therapeutic bioactive agents that may improve wound healing. Generally, these flavonoid C-glycosides were reported to possess high antioxidant [22][23][24], and anti-inflammatory activities [16,17], and may be associated with wound healing enhancement. Further studies should be conducted on the correlation of these activities and wound healing properties in OPL extracts and flavonoid enriched extracts.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Wound Healing Potential of Flavonoid C-Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaves on 3T3 Fibroblast Cells

et al. 2020

View full text Add to dashboard Cite

Oil palm (Elaeis guineensis Jacq.) leaves (OPL) are widely available at zero cost in Southeast Asia countries, especially in Malaysia and Indonesia due to large scale oil palm plantations. OPLs contain a large amount of flavonoids in particular flavonoid C-glycosides, which are known to possess useful biological properties including antioxidant and wound healing properties. The present study aimed at evaluating the wound healing efficacy of OPL in various solvent extracts and flavonoid enriched fractions and to determine the contribution of flavonoid C-glycosides (orientin, isoorientin, vitexin and isovitexin) using in-vitro scratch assay on 3T3 fibroblast cells. Solvent crude extracts with different polarity were screened and the most active extract was subjected to acid hydrolysis. The crude and acid hydrolysed extracts were further enriched using macroporous resins, XAD7HP. UHPLC-UV/PDA and LC-MS/MS analysis were applied for identification and confirmation of flavonoid C-glycosides. The wound healing properties comprised of cell viability, cell proliferation and cell migration were studied. Allantoin was used as a positive control to compare the efficacy among the tested samples. The results revealed all OPL crude extracts, flavonoid enriched fractions and flavonoid C-glycosides were non-toxic at concentrations below 25 µg/mL and showed better cell proliferation and migration activities at low concentrations than higher concentrations.. This study also demonstrated orientin, isoorientin, vitexin and isovitexin presented in OPL extracts and flavonoid enriched fractions stimulated proliferation and migration of 3T3 fibroblast cells. Hence, these findings may pose potential therapeutic bioactive agents for wound healing by enhancing fibroblast proliferation and migration.

show abstract

Section: Discussionmentioning

confidence: 99%

In Vitro Wound Healing Potential of Flavonoid C-Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaves on 3T3 Fibroblast Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The cotton pellet induction of granuloma is a model for the proliferative phase of inflammation, which develops over a period of several days (Lalitha and Sethuraman, 2010). The antiinflammatory activity of the extract was assessed after the eighth day by measuring the weight of the granulomas.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis

Santa-Cecília

Vilela

Rocha

et al. 2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…linneanum has been reported to possess many ritual uses such as in jaundice, menorrhoea, rheumatism (Chopra et al, 1956), anti-inflammatory activity (Lalitha and Sethuraman, 2010). Root juice is used as anti-helmintic and also to treat premenstrual colic (Sharma and Sharma, 2010).…”

Section: Ecbolium Linneanummentioning

confidence: 99%

Review on Medicinal and Pharmacological Properties of <i>Iresine herbstii, Chrozophora rottleri</i> and <i>Ecbolium linneanum</i>

Dipankar¹,

Sevanan²,

Devi³

2011

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

India has a rich tradition of plant-based knowledge on healthcare. A large number of plants/plant extracts/decoctions or pastes are equally used by tribals and folklore traditions in India for treatment of cuts, wounds and burns. The resistance of the microorganism has increased due to the indiscriminate use of commercial antimicrobial drugs commonly used for the treatment of infectious diseases. Resistance to antimicrobial agents has resulted in morbidity, mortality, from treatment failures and increased health care costs. There is an urgent need to discover novel, effective plant-based antimicrobial drug to the increasing problem of drug resistance. This situation forced the scientist to search for new antimicrobial substances from various sources including medicinal plants. Iresine herbstii, Ecbolium linneanum , Chrozophora rottleri have been used in folk remedies and is reported to have a broad range of therapeutic effects. Therefore this paper attempts to bridge the lacunae in the existing literature and offers immense scope for researchers engaged in validation of the traditional claims and development of safe and effective therapeutic agent.

show abstract

Anti-inflammatory activity of roots of Ecbolium viride (Forsk) Merrill

Cited by 24 publications

References 10 publications

In Vitro Wound Healing Potential of Flavonoid C-Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaves on 3T3 Fibroblast Cells

In Vitro Wound Healing Potential of Flavonoid C-Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaves on 3T3 Fibroblast Cells

Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis

Review on Medicinal and Pharmacological Properties of <i>Iresine herbstii, Chrozophora rottleri</i> and <i>Ecbolium linneanum</i>

Contact Info

Product

Resources

About