Anti-inflammatory activity of polysaccharide from Pholiota nameko

Abstract

Pholiota nameko polysaccharide (PNPS-1) has been isolated and purified by enzymatic hydrolysis, hot water extraction, ethanol precipitation, and ion-exchange and gel-filtration chromatography. The anti-inflammatory activity of PNPS-1 was evaluated in rodents using xylene-induced ear edema, egg albumin-, carrageenin-, and formaldehyde-induced paw edema, cotton pellet granuloma test, adhesion of peritoneal leukocytes in vitro, and ulcerogenic activity. The results showed that PNPS-1 (5 mg/ear) inhibited topical edema in the mouse ear and at 100, 200, and 400 mg/kg (intraperitoneally) it significantly suppressed the development of egg albumin-, carrageenin-, and formaldehyde-induced paw edema in the animals. PNPS-1 (100, 200, and 400 mg/kg, per oral) significantly inhibited the growth of granuloma tissues induced by subcutaneously implanted cotton pellets in rats by 10.96, 18.07, and 43.75%, respectively. PNPS-1 also inhibited spontaneous and phorbol-12-myristate-13-acetate-activated adhesion of peritoneal leukocytes in vitro. Further, both acute as well as chronic administration of PNPS-1 (100, 200, and 400 mg/kg, per oral) did not produce any gastric lesion in rats. In conclusion, these data indicated that PNPS-1 possesses significant anti-inflammatory activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory-related diseases.

Characterisation of the chemical composition and in vitro anti-inflammation assessment of a novel lotus (Nelumbo nucifera Gaertn) plumule polysaccharide

“…Li, Lu, Zhang, Lu, and Liu (2008) indicated that Pholiota nameko polysaccharide possesses significant anti-inflammatory activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory-related diseases . This study further suggests that LPPS administration may modulate autoimmune diseases, such as T1D, via its potent anti-inflammatory activities.…”

Phytochemical screening and anti-inflammatory properties of AlgerianHertia cheirifoliamethanol extract

“…In this acute inflammatory model, the proliferation of macrophages, neutrophils, and fibroplasts are the sources of inflammation (Li et al 2008). The present study revealed that methanol extract of H. cheirifolia inhibited neutrophil recruitment into the cavity of the air pouch.…”

Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-κB and MAPK activities in RAW 264.7 macrophage cells

“…An increasing number of studies demonstrated the ability of mushroom extracts or mushroom-derived moieties to exhibit anti-inflammatory effects (31)(32)(33)(34)(35)(36)(37)(38). Anti-inflammatory activity was mediated by polysaccharides (38) or by small molecules such as cordycepin (34), grifolin (33,37), ergosterol peroxide (35), cycloepoxydon (32), panepoxydone (31), and caffeic acid phenethyl ester (CAPE) (39,40).…”