Anti-Inflammatory Activity of Polysaccharide Fraction of Curcuma longa Extract (NR-INF-02)

Illuri, Ramanaiah; Bethapudi, Bharathi; Anandakumar, Senthilkumar; Murugan, Sasikumar; Joseph, Joshua Allan; Mundkinajeddu, Deepak; Agarwal, Amit; Chandrasekaran, C.V.

doi:10.2174/1871523014666150407150533

Cited by 22 publications

(16 citation statements)

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“…Bioactive polysaccharides derived from medicinal plants have gained many interests especially for biomedical applications due to their various pharmacological activities including wound healing stimulation [1], inhibition of cancer cell growth [2], modulation of immune responses [3], reduction of inflammation [4, 5] and inhibition of bacterial growth [6]. Several methods have been used to evaluate these bioactive phytocompounds with high sensitivity, resolution and quantitative detection such as high‐performance liquid chromatography [7], gas chromatography mass spectrometry [8] and Fourier transform infrared spectroscopy (FTIR) [9].…”

Section: Introductionmentioning

confidence: 99%

Electrospun cellulose acetate membrane for size separating and antibacterial screening of crude polysaccharides

Chumpol

Siri

2016

IET nanobiotechnol.

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This study aims to produce electrospun cellulose acetate (CA) membrane as the alternative supporting medium for a separation of crude polysaccharides by electrophoresis and a screening of their antibacterial activity. Among the tested conditions of fabrication, electrospun CA membrane at 57% porosity showed the best separation of each polysaccharide from the standard mixture and the crude extract of via electrophoresis. As compared with the commercial CA membrane, the produced electrospun CA membrane demonstrated more separated spots of polysaccharides. The antibacterial activity of the electrophoretic polysaccharide was also determined against and as the inhibition zone after the bacterial culture agar was overlaid on the membrane and incubated for 24 h. The results of this study suggested the potential application of electrospun CA membrane combining with electrophoresis as a simple method for separating crude polysaccharides and screening for their antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Electrospun cellulose acetate membrane for size separating and antibacterial screening of crude polysaccharides

Chumpol

Siri

2016

IET nanobiotechnol.

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“…2013[ 8 ] and Illuri et al . 2015[ 10 ] These two studies indicated that turmerosaccharides of NR-INF-02 contributed to the anti-inflammatory effects. The analgesic effect of turmerosaccharides rich fraction appears to be similar to the anti-nociceptive activity of synthetic drugs, tramadol that resulted in 55% of anti-nociceptive activity.…”

Section: Resultsmentioning

confidence: 99%

“…420. [ 10 ] Thus, these studies clearly indicated that the possible anti-inflammatory activity of NR-INF-02 is primarily due to turmerosaccharides. However, the turmerosaccharides rich fraction was not investigated in in vivo monosodium iodoacetate (MIA)-induced osteoarthritic (OA) pain model.…”

Section: Introductionmentioning

confidence: 90%

Bioactive turmerosaccharides from Curcuma longa Extract (NR-INF-02): Potential ameliorating effect on osteoarthritis pain

et al. 2017

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Background:Curcuma longa has long history of medicinal use in Ayurveda. A unique product NR-INF-02 was prepared from C. longa that was standardized to contain turmerosaccharides.Objective:The present study investigated the effect of turmerosaccharides rich fraction of NR-INF-02 on monosodium iodoacetate (MIA)-induced OA pain animal model that mimics human OA. Further, the analgesic effect of turmerosaccharides rich fraction was compared to turmerosaccharides less fraction of NR-INF-02.Materials and Methods:OA pain was chemically induced by intra-articular administration of single dose of 25 μl of 0.9% saline containing 0.3 mg MIA into the right knee of male albino Wistar rat. Turmerosaccharides rich fraction and turmerosaccharides less fraction (at 22.5, 45 and 90 mg/kg rat body weight dose levels) were administered as a single dose orally on day 5 of post-MIA injection. OA pain was measured using hind limb weight-bearing ability at 1, 3, 6, and 24 h post-test substance administration on day 5.Results:Oral administration of turmerosaccharides rich fraction and turmerosaccharides less fraction (at 45 and 90 mg/kg) although significantly decreased the OA pain at all the intervals, the effect of turmerosaccharides rich fraction (57%) on OA pain was superior to turmerosaccharides less fraction (35%).Conclusion:Bioactive turmerosaccharides from C. longa extract contribute to the observed anti-arthritic effect in rats.SUMMARY Osteoarthritic pain was induced by intra-articular injection of MIA into the right kneeSingle administration of TRF/TLF on day 5 resulted in dose-dependent significant reduction of OA painTRF showed better analgesic activity than TLFTRF at 45 and 90 mg/kg has similar effects on OA pain as that of tramadolTurmerosaccharides identified as bioactive constituents of C. longa extract. Abbreviations used: MIA: Monosodium iodoacetate; i.ar: Intra-articular; OA: Osteoarthritis; TRF: Turmerosaccharides rich fraction; TLF: Turmerosaccharides less fraction; PGE2: Prostaglandin E2; ROS: Reactive oxygen species.

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“…In the past decades, some bioactive polysaccharides have attracted much research attention owing to their wide range of biological activities, such as anti‐viral, anti‐inflammatory, antioxidant, anti‐ulcer, immunostimulatory, antitumor activity and so on . It is also worth mentioning that these natural polysaccharides have been recognized as a source of safe and potent natural medicine because of their lower toxicity and higher efficacy .…”

Section: Discussionmentioning

confidence: 99%

A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)‐induced osteoporosis in rats

Sun

Wei

Peng

et al. 2020

J Cellular Molecular Medi

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In the present study, a homogenous polysaccharide (DFPW) was isolated and purified from the dried rhizome of Drynaria fortunei, and its protective effect against osteoporosis was investigated in ovariectomized (OVX) rats. Histological analysis indicated that oral administration of DFPW (100 and 400 mg/kg) for 12 weeks significantly improved trabecular bone mass, as demonstrated by the increase in trabecular area, trabecular thickness and its number in OVX rats. Furthermore, the decline of bone mineral density and bone mineral content including Ca, P and Mg induced by OVX was reversed by the DFPW administration. This function was achieved by the decreased levels of the bone turnover markers, such as serum ALP, urinary deoxypyridinoline (DPD), Ca and P excretions. Besides, DFPW improved biomechanical parameters (maximum load, energy, Young's, modulus and maximum stress) to strengthen the hardness and strength femoral diaphysis in OVX rats. These results strongly suggested that DFPW might be a hopeful alternative therapeutics to treat postmenopausal osteoporosis.

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Anti-Inflammatory Activity of Polysaccharide Fraction of Curcuma longa Extract (NR-INF-02)

Cited by 22 publications

References 0 publications

Electrospun cellulose acetate membrane for size separating and antibacterial screening of crude polysaccharides

Electrospun cellulose acetate membrane for size separating and antibacterial screening of crude polysaccharides

Bioactive turmerosaccharides from Curcuma longa Extract (NR-INF-02): Potential ameliorating effect on osteoarthritis pain

A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)‐induced osteoporosis in rats

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