Anti-Inflammatory Activity of Phycocyanin Extract in Acetic Acid-Induced Colitis in Rats

González, Ricardo; Rodríguez, Sandra; Romay, Cheyla; González, Amnely; Armesto, Julia; Remírez, Diadelis; Merino, Nelsón

doi:10.1006/phrs.1998.0409

Cited by 188 publications

(102 citation statements)

References 16 publications

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“…In agreement with our study, Abdel -Daim et al showed decreased colonic MPO by 15 days of SP preadministration (500 mg/kg) in colitis rats (1). In a very short period intervention, phycocyanin significantly reduced colonic MPO when administered 30 minutes before colitis induction (31). The present investigation showed that the pretreatment of rats with SP and honey individually and in combination had protective effects against oxidative stress and lipid peroxidation, as presented by reduced colonic MDA, a marker of lipid peroxidation in tissues (10).…”

Section: Discussionsupporting

confidence: 93%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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Background: Overproduction of reactive oxygen species (ROS) causes increased lipid peroxidation, decreased intestinal epithelial barrier integrity, and ultimately mucosal disruption and ulceration. Several studies have confirmed the antioxidant, antiinflammatory, and immunomodulatory properties of Spirulina Platensis (SP), edible blue -green algae, in various inflammatory diseases. In addition, natural honey, a source of phenolic and flavonoid compounds, is a powerful antioxidant, which can help prevent chronic oxidative stress and subsequent inflammation. Objectives: In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats. Methods: Forty male rats were allocated into five groups (N = 8) and received pretreatment for 32 consecutive days. The administrations were as follows: group 1 (control) and group 2 (AA-colitis group): normal saline, group 3: 1 ml honey/day, group 4: 1 ml honey/day plus 1 g/kg SP, and group 5: 1 g/kg SP. Colitis was induced on the 30th day in groups 2 to 5. On day 32, the clinical activity was determined and anesthetized animals were sacrificed. Serum interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), colonic tissues myeloperoxidase (MPO), prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined. In addition, histopathological changes of the colon were observed microscopically.

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Section: Discussionsupporting

confidence: 93%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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“…The acetic acid rat model applied in the current study is commonly used to produce acute colitis mimicking the inflammatory response in human IBD. The model was validated by using several drugs applied in treatment of IBD and finding similar profile effects in murine and human colonic specimens [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

El-Galil¹,

ElGhamrawy²

2015

J Cytol Histol

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“…Red algae were reported to contain active secondary metabolites that may inhibit inflammation (Kang et al 2008), prevent or treat gastric ulcers and cancers caused by oxidative stress (Gonzalez et al 1999;Yeh et al 2012), inhibit inflammatory activities by suppressing the production of inflammatory mediators (Khan et al 2007 and induce cancer cell apoptosis in colon (Synytsya et al 2010) and stomach (Kwon & Nam 2007). Natural compounds derived from the edible algae could be used as anti-inflammatory, analgesic and antiulcerogenic therapeutics as they have been taken in alimentation and used in traditional medicines in the last centuries (Dhargalkar & Pereira 2005).…”

Section: Introductionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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Context: Red algae have been recognized as a rich natural source of compounds possessing interesting biological and pharmacological activities. Objective: This work investigates anti-inflammatory, analgesic and gastroprotective activities of MeOH/ CH 2 Cl 2 crude extract and its fractions F1 (50% MeOH) and F2 (80% MeOH) from the whole alga plant Laurencia obtusa Hudson (Rhodomelaceae). Materials and methods: Anti-inflammatory activity was evaluated in vitro using cytometric bead array (CBA) technology to follow up the secretion of tumour necrosis factor alpha (TNF-a) in lipopolysaccharide activated THP-1 monocytic cells at doses of 10-250 lg/mL and in vivo using carrageenan-induced paw oedema in Wistar rats at doses of 25, 50, 100 and 200 mg/kg. Crude extract and fractions were tested at the doses of 25, 50, 100 and 200 mg/kg for peripheral and central analgesic activity by acetic acid-induced writhing test and hot-plate method, respectively, in Swiss albino mice. Gastroprotective activity was evaluated using HCl/ethanol-induced gastric ulcer test in rats at doses of 25, 50, 100 and 200 mg/kg. Results: Crude extract, F1 and F2 showed an interesting inhibition of TNF-a secretion with IC 50 values of 25, 52 and 24 lg/mL, respectively, and a significant anti-inflammatory activity in vivo (p < 0.01), 3 h after carrageenan injection, the oedema inhibition was 55.37%, 52.18% and 62.86%, respectively, at the dose of 100 mg/kg. Furthermore, they showed a significant peripheral analgesic activity with 53.79%, 55.92% and 57.37% (p < 0.01) of writhing inhibition, respectively. However, no significant activity was found in the hotplate test. An interesting gastroprotective effect was observed with crude extract and its fractions F1 and F2 with a gastric ulcer inhibition of 65.48%, 77.42% and 81.29%, respectively, at the dose of 50 mg/kg. Discussion and conclusion: These results suggest that L. obtusa might be used as a potential source of natural anti-inflammatory and analgesic agents with gastroprotective effect. ARTICLE HISTORY

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Anti-Inflammatory Activity of Phycocyanin Extract in Acetic Acid-Induced Colitis in Rats

Cited by 188 publications

References 16 publications

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

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