Anti-inflammatory activity of methanolic extracts from edible mushrooms in LPS activated RAW 264.7 macrophages

Moro, Carlos; Palacios, Irene; Lozano, Miguel; D’Arrigo, M.; Guillamón, Eva; Villares, Ana; Martínéz, J. Alfredo; García–Lafuente, Ana

doi:10.1016/j.foodchem.2011.07.049

Cited by 163 publications

(110 citation statements)

References 37 publications

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“…It is usually associated with the pathogenesis of diseases such as diabetes, arthritis, obesity, metabolic syndrome, cancer and several cardiovascular diseases (Bellik et al, 2012;Moro et al, 2012;Ma, Chen, Dong, & Lu, 2013). …”

Section: Introductionmentioning

confidence: 99%

“…An immune stimulant causes the pro-inflammatory cells, such as macrophages and monocytes, to start to secrete a number of inflammatory mediators such as interleukins (IL 1β,, tumor necrosis factor (TNF-α), nuclear factor-κB (NF-κB), intercellular adhesion molecule-1 (ICAM-1), inducible type cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), 5-lipoxygenase (5-LOX), and inducible nitric oxide synthase (iNOS) (Moro et al, 2012;Choi et al, 2014a;Taofiq et al, 2015). Uncontrolled production of these inflammatory mediators has been known to cause several cell damage and also initiate the inflammation process (Kanwar, Kanwar, Burrow, & Baratchi, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…They have not just been consumed for their culinary importance because of their unique taste and flavour (Kalač, 2013), but also because of their potential therapeutic properties which dates back to over 2000 years ago and are recognized as effective to treat and prevent varieties of disorders (Lim et al, 2007;Moro et al, 2012;Silveira et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…antimicrobial (Alves et al, 2012(Alves et al, , 2013a, immunomodulator (Borchers, Krishnamurthy, Keen, Meyers, & Gershwin, 2008), antiatherogenic (Mori, Kobayashi, Tomita, Inatomi, & Ikeda, 2008) hypoglycemic (Hu, Wang, Lien, Liaw, & Lee, 2006) and anti-inflammatory (Moro et al, 2012;Tung et al, 2013;Xu et al, 2013;Choi et al, 2014a;Taofiq et al, 2015) activities.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, the antiinflammatory activity of several mushroom species has been reported as well as of their bioactive metabolites. It has been related with a reduction in the production of nitric oxide (NO) and other inflammatory mediators such as interleukins (IL 1β,, tumor necrosis factor (TNF-α) and prostaglandin E2 (PGE2), causing reduction of inflammation (Jedinak, Dudhgaonkar, Wu, Simon, & Sliva, 2011;Moro et al, 2012;Fangkrathok, Junlatat, NF-κB is a transcription factor that regulates the expression of several pro-inflammatory cytokines and enzymes such as IL-1β, TNF-α, iNOS, and COX-2 that play vital roles in apoptosis, in the immune system, as well as in the inflammation (Hseu, Huang, & Hsiang, 2010). When there is an immune stimulant such as lipopolysaccharide, viral proteins or cytokines, the NF-κB becomes activated (Kim et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%