Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages

Zhong, Ying; Chiou, Yi-Siou; Pan, Min‐Hsiung; Shahidi, Fereidoon

doi:10.1016/j.foodchem.2012.02.172

Cited by 188 publications

(122 citation statements)

References 27 publications

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“…The potencies of the inhibitory activities of (-)-epicatechin on Raw 264.7 mouse macrophages are comparable to those of epigallocatechin gallate (EGCG), another anti-inflammatory compound isolated from green tea [12].…”

Section: Discussionmentioning

confidence: 87%

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Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages

Wang¹,

ZhiRan²

2014

Trop. J. Pharm Res

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Purpose: To investigate the protective effects of (-)-epicatechin on lipopolysaccharide (LPS)-induced inflammation in Raw 264.7 murine macrophages and the possible underlying mechanisms. Methods: The effects of epicatechin on LPS-stimulated production of inflammatory mediators in Raw 264.7 cells were evaluated by enzyme-linked immunosorbent assay. Results: Epicatechin in doses of 5, 25 and 50 µM remarkably (p < 0.05) inhibited the production of proinflammatory mediators including nitric oxide (NO) and prostaglandin E2 (PGE2), as well as the production of pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in LPS-induced Raw 264.7 macrophages. Conclusion:The results suggest that epicatechin can inhibit inflammatory response and may be a potential therapeutic candidate for the treatment of chronic inflammatory diseases.

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Section: Discussionmentioning

confidence: 87%

“…These beneficial effects of flavonoids might be partially attributed to their anti-oxidative capacity. Epicatechin is a natural phenolic compound found widely in plants, and possesses anti-oxidative, anti-cancer and other biological activities [12,13].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages

Wang¹,

ZhiRan²

2014

Trop. J. Pharm Res

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“…The activity observed with the studied extracts is probably due to the presence of active substances that can cross the skin barrier and exert anti-inflammatory effect (Manga et al 2004). Flavonoids and polyphenols are likely candidates for this effect (Gonzalez et al 2011;Zhong et al, 2012).…”

Section: Discussionmentioning

confidence: 91%

Phenolic content, anti-inflammatory and antioxidant activities of Anacyclus clavatus extracts

Bouriche¹,

Kherbache²,

Kada³

et al. 2016

EEB

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The anti-inflammatory and the antioxidant activities of methanol (ME) and aqueous (AE) extracts of Anacyclus clavatus were evaluated. Phenolic constituents in the extracts were screened. Croton oil-induced ear edema in mice, carrageenan-induced paw edema and pleurisy in rats were evoked. The antioxidant effect was tested by 1,1-diphenyl-2-picrylhydrazyl, ion chelating, lipid peroxidation tests. Both extracts are rich in phenolic compounds. The application of 2 mg per ear of ME or AE inhibited ear edema by 84 and 83 %, respectively. The oral treatment of rats with 200 or 400 mg kg -1 of ME reduced paw edema by 64 and 74%, respectively, whereas the inhibition by AE was by 65 and 80%, respectively. At 400 mg kg -1 , the extracts decreased exudation and neutrophil migration into the pleural cavity by 64 and 66%, respectively, while the inhibition by AE was 42 and 55%, respectively. On the other hand, ME exerted scavenging activity higher than AE, while the AE chelating activity was more than that of ME. However, both extracts had similar inhibitory effect on lipid peroxidation. In general, A. clavatus may be used as a source of anti-inflammatory and anti-oxidant agents.

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“…Previous studies have also shown that EGCG improves glucose tolerance, protects pancreatic islets, ameliorates aortic reactivity and the development of diabetic nephropathy [30], suppresses high glucose-induced apoptosis, ameliorates hyperglycemia-induced embryonic vasculopathy, and attenuates glucotoxicity [31]. Moreover structural modification of EGCG to produce lipophilic ester derivatives has been shown to enhance its cellular absorption and bioefficiency in vivo [32], thereby indicating the possibility of improvement in its pharmacokinetic profile.…”

Section: Discussionmentioning

confidence: 98%

Green Tea Polyphenol Epigallocatechin-3-<i>O</i>-Gallate Attenuates Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Cells

Lee¹,

Kang²,

Lee³

et al. 2014

JFNR

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Epigallocatechin-3-O-gallate (EGCG), the major polyphenol found in green tea, has been shown to downregulate inflammatory responses in macrophages; however, the underlying mechanism has not been understood. Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) is known to be closely correlated with the pathology of a variety of diseases and inflammations. In this study, we investigated the inhibitory effect of EGCG on NO production and its molecular mechanism in lipopolysaccharide (LPS)-stimulated macrophage RAW264.7 cells. Besides a decrease in NO secretion, protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) also decreased in LPS-stimulated RAW264.7 macrophage cells treated with EGCG. These results suggest that EGCG possesses a potent anti-inflammatory activity.

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Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages

Cited by 188 publications

References 27 publications

Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages

Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages

Phenolic content, anti-inflammatory and antioxidant activities of Anacyclus clavatus extracts

Green Tea Polyphenol Epigallocatechin-3-<i>O</i>-Gallate Attenuates Lipopolysaccharide-induced Nitric Oxide Production in RAW264.7 Cells

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