Anti-Inflammatory Activity of Essential Oil from Zingiber ottensii Valeton in Animal Models

Abstract

Zingiber ottensii (ZO) Valeton, a local plant in Northern Thailand, has been widely used in traditional medicine. Many studies using in vitro models reveal its pharmacological activities, including the anti-inflammatory activity of ZO essential oil, extracted from ZO rhizomes. However, the scientific report to confirm its anti-inflammatory activity using animal models is still lacking. The present study aimed to evaluate the anti-inflammatory activity and explore the possible mechanisms of action of ZO essential oil in rats. The results revealed that ZO essential oil significantly reduced the ear edema formation induced by ethyl phenylpropiolate. Pre-treatment with ZO essential oil significantly reduced the carrageenan-induced hind paw edema and the severity of inflammation in paw tissue. In addition, pre-treatment with ZO essential oil exhibited decreased COX-2 and pro-inflammatory cytokine TNF-α expression in paw tissue, as well as PGE2 levels in serum. On this basis, our study suggests that ZO essential oil possesses anti-inflammatory activity in animal models. Its possible mechanisms of action may involve the inhibition of TNF-α expression as well as the inhibition of COX-2 and PGE2 production. These findings provide more crucial data of ZO essential oil that may lead to new natural anti-inflammatory product development in the future.

Sugarcane molasses essential oils: mesoporous silica nanoparticles as carriers to improve their slow-release activity and the study on their anti-inflammatory activities in vivo

“…49 By evaluating the anti-inflammatory activity of Zingiber ottensii (ZO) essential oil in rats, it was found that its possible mechanism was to inhibit TNF-α expression and inhibit COX-2 and PGE2 production. 50…”

“…49 By evaluating the anti-inflammatory activity of Zingiber ottensii (ZO) essential oil in rats, it was found that its possible mechanism was to inhibit TNF-α expression and inhibit COX-2 and PGE2 production. 50 Effect of SMEOs on acetic acid-induced peritoneal permeability increased inflammation in mice. In this experiment, the peritoneal permeability in mice was destroyed by acetic acid.…”

Repurposing Inhaled Ibuprofenate, a Non Steroidal Anti‐Inflammatory Drug, as a Potential Adjuvant Treatment for Pneumonia, CARDS and its Aetiological Agent SARS‐CoV‐2

“…NaIHS, by direct inhibition of COX‐2, may inhibit all of the above‐mentioned local inflammatory mediators: prostaglandins, 12 prostacyclins, 12 histamines, 38 bradykinins 6,33,39 and NO 31 and thus it may prevent vasodilation and pulmonary oedema. In the particular case of bradykinin, it is worth mentioning that NaIHS, through the aforementioned COX2‐dependent mechanism, may produce two effects: on the one hand, it may lead to down‐regulation of the bradykinin B2 receptor (B2R) 39 and on the other hand, it may promote ACE2 up‐regulation, as mentioned above 33 .…”

“…IL‐8, 27 IL‐10, 27 IL‐18, 24 tumor necrosis factor‐alpha (TNF‐α), 13 interferon‐gamma (IFN‐γ), 13 transforming growth factor‐beta 1 (TGF‐β1), 13 intercellular adhesion molecule‐1 (ICAM‐1), 13 vascular adhesion molecule‐1 (VCAM‐1), 28 E‐selectin, 12 monocyte chemoattractant protein 1 (MCP‐1), 27 chemokine (C‐C motif) ligand 2 (CCL2), 27 growth factors granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) 29 and hepatocyte growth factor (HGF) 27 ; (3) Down‐regulation of nitric oxide (NO) hyperproduction : see Table 3; (4) Inhibition of the main local inflammatory mediators : by COX2 inhibition effect, it may inhibit prostaglandins, 12 prostacyclins, 12 histamine, 38 bradykinins 6,33,39 and NO 31 and (5) Antiangiogenic effect : by COX‐2 inhibition effect, it would negatively modulate vascular endothelial growth factor (VEGF), 40,42 basic fibroblast growth factor (bFGF), 40,42 CCL2, 27 HGF, 27 extracellular signal‐regulated kinase 2 (ERK2), 40 mitogen‐activated protein kinase (MAPK), 40 cyclin‐dependent kinase 1/2 (CDK 1/2), 40 checkpoint kinase 1 (CHK1), 40 cyclin A, 40 via Apelin/G protein‐coupled receptor (APJ) 40 and, by COX‐independent effect, NaIHS would inhibit hypoxia inducible factor‐1 alpha (HIF‐1α) 37 and HIF‐2α 43 . .…”

A descriptive review on exploiting the therapeutic significance of essential oils as a potential nutraceutical and food preservative

“…In general, EOs are isolated from the aqueous phase using a physical technique resulting in no or little significant changes in their chemical profile. To generate these aromatic oily liquids, various plant segments such as seeds, leaves, flowers, peels, buds, and others are employed, and various extraction procedures are used (Thitinarongwate et al., 2022).…”