Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense

Nesterova, Yu. V.; Povetieva, T. N.; Суслов, Н. И.; Zyuz’kov, G. N.; Aksinenko, S. G.; Пушкарский, С. В.; Krapivin, A. V.

doi:10.1007/s10517-014-2421-4

Cited by 36 publications

(17 citation statements)

References 1 publication

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“…Hypaconitine from the root of Aconitum species can suppress 0.1% histamine-induced acute inflammation without showing an ulcerogenic effect [199]. Hypaconitine (8 µM) can inhibit TGF-1-evoked EMT of A549 lung cancer cells possibly by blocking NF-κB activation [200].…”

Section: Reversal Of Emt By Anti-inflammatory Natural Compoundsmentioning

confidence: 99%

Reversal of Epithelial–Mesenchymal Transition by Natural Anti-Inflammatory and Pro-Resolving Lipids

Lee

2019

Cancers

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Epithelial mesenchymal transition (EMT) is a key process in the progression of malignant cancer. Therefore, blocking the EMT can be a critical fast track for the development of anticancer drugs. In this paper, we update recent research output of EMT and we explore suppression of EMT by natural anti-inflammatory compounds and pro-resolving lipids.A typical signaling pathway of EMT is the transforming growth factor-β1 (TGF-β1) pathway. TGF-β1 induces EMT via SMAD-dependent or non-SMAD signaling pathway [7]. Growth factors including FGF, HGF, IGF1, EGF, and PDGF via receptor tyrosine kinase can induce EMT via signaling pathway of PI3K-AKT and ERK MAPK [8][9][10][11]. Wnt signaling, hedgehog signaling, Notch signaling, hypoxia, and inflammatory tumor microenvironment also involves in EMT [5]. Recently, it has been shown that hippo signaling is also involved in EMT [12]. YAP and TAZ can enhance EMT through upregulation of EMT transcription factors such as forkhead box C2 (FOXC2), snail family zinc finger 1/2 (SNAIL1, SLUG), twist-related protein 1 (TWIST1), and ZEB1 [12-15]. Transcription Factors Involved in EMTNovel players are newly recognized as regulatory transcription factor in the EMT. Brachyury, the T-box transcription factor, is a novel transcription factor implicated in the EMT of cancer cells [16]. Brachyury is known as the target gene of WNT, one of the m ajor signaling pathways of EMT [17]. Foxq1, one of forkhead transcription factor, has also regarded as a novel transcription factor mediating the EMT of gastric cancer [6,18]. Runt-related transcription factor 2 (Runx2) belongs to the runt-related transcription factor family [19]. Runx2 plays a key role in EMT of hepatocellular carcinoma (HCC) [20]. GATA transcription factors are also implicated in the EMT of cancer cells [21].A typical signaling pathway of EMT is the transforming growth factor-β1 (TGF-β1) pathway. TGF-β1 induces EMT via SMAD-dependent or non-SMAD signaling pathway [7]. Growth factors including FGF, HGF, IGF1, EGF, and PDGF via receptor tyrosine kinase can induce EMT via signaling pathway of PI3K-AKT and ERK MAPK [8][9][10][11]. Wnt signaling, hedgehog signaling, Notch signaling, hypoxia, and inflammatory tumor microenvironment also involves in EMT [5]. Recently, it has been shown that hippo signaling is also involved in EMT [12]. YAP and TAZ can enhance EMT through upregulation of EMT transcription factors such as forkhead box C2 (FOXC2), snail family zinc finger 1/2 (SNAIL1, SLUG), twist-related protein 1 (TWIST1), and ZEB1 [12-15]. Transcription Factors Involved in EMTNovel players are newly recognized as regulatory transcription factor in the EMT. Brachyury, the T-box transcription factor, is a novel transcription factor implicated in the EMT of cancer cells [16]. Brachyury is known as the target gene of WNT, one of the major signaling pathways of EMT [17]. Foxq1, one of forkhead transcription factor, has also regarded as a novel transcription factor mediating the EMT of gastric cancer [6,18]. Runt-related transcription factor 2 (Runx2...

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Section: Reversal Of Emt By Anti-inflammatory Natural Compoundsmentioning

confidence: 99%

Reversal of Epithelial–Mesenchymal Transition by Natural Anti-Inflammatory and Pro-Resolving Lipids

Lee

2019

Cancers

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“…These alkaloids activate mesenchymal stem cells thereby increasing wound healing [33,34]. The anti-inflammatory effect of both compounds was comparable to diclofenac, in histamine-induced acute inflammation model in mice [20]. In rats, intraperitoneal administration of both compounds was shown to reduce painful reaction induced by acetic acid.…”

Section: Introductionmentioning

confidence: 99%

In vivo screening of diterpene alkaloids using bdelloid rotifer assays

Kiss

Mácsai

Csupor

et al. 2017

Acta Biologica Hungarica

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The group of diterpene alkaloids contains numerous compounds with complex chemistry and diverse pharmacological activities. Beside toxicity, these compounds possess activity on the cardiovascular system, tumor cell lines and nervous system. The pharmacological properties have been described using in vitro and in vivo techniques; however, the bioactivities of many compounds have not thoroughly been studied. Here we report on the in vivo evaluation of ten diterpene alkaloids using bdelloid rotifer assays. Napelline exerted toxic effects on rotifers, while wide tolerance range was observed for other investigated compounds. Weak toxicity of songorine is supported by our experiment. Toxicological data for senbusine A, senbusine C, septentrioidine and hetisinone are reported for the first time.

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“…brachy podum, has various biological activities, including anti-arrhythmia, anti-anxiety, analgesia, anti-inflammatory, anti-infection and promoting tissue regeneration. [4][5][6][7][8] Our recent studies indicated that songorine (IC50 = 3.21 nM) had an inhibitory effect on Class B GPCRs in vitro utilizing Double Antibody Sandwich ELISA (DAS-ELISA), a rapid and sensitive method completed by combining antigens with antibodies, [9,10] which is suitable for preliminary screening.…”

mentioning

confidence: 99%

New Songorine Derivatives as Novel G Protein-Coupled Receptor Antagonists: Syntheses and Preliminary Bioactivities Assay

Wang¹,

Guo²

2019

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In our early screening process, songorine isolated from Aconitum brachypodum diels possessed prominent activity of inhibiting class B G protein-coupled receptors (GPCRs). For further study, a series of ester and carbonyl derivatives were synthesized and their potential inhibitory activities on class B GPCRs were also assayed by the Double Antibody Sandwich ELISA (DAS-ELISA) in vitro. Moreover, the structure-activity relationships (SARs) of songorine derivatives were discussed in detail. In this paper, the story behind this study was described.

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Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense

Cited by 36 publications

References 1 publication

Reversal of Epithelial–Mesenchymal Transition by Natural Anti-Inflammatory and Pro-Resolving Lipids

Reversal of Epithelial–Mesenchymal Transition by Natural Anti-Inflammatory and Pro-Resolving Lipids

In vivo screening of diterpene alkaloids using bdelloid rotifer assays

New Songorine Derivatives as Novel G Protein-Coupled Receptor Antagonists: Syntheses and Preliminary Bioactivities Assay

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