Anti-inflammatory activity of Commiphora molmol

Tariq, Mohammad; Ageel, A. M.; Al-Yahya, Mohammed A.; Mossa, Jaber S.; Alsaid, Mansour S.; Parmar, N. S.

doi:10.1007/bf01982655

Cited by 100 publications

(98 citation statements)

References 2 publications

(2 reference statements)

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“…T. polium extract contains selenium (Jurisic et al, 2003) and has shown antioxidant activity (Ljubuncic et al, 2006) like a-tocopherol. Some studies state the anti-inflammatory effects of T. polium extract (Tariq et al, 1989;Ljubuncic et al, 2005). Antibacterial activity against some Gram-positive and Gram-negative bacteria (Autore et al, 1984) as well as antifungal activity against Yarrovia lipolitica and Saccharomyces cerevisiae (Aggelis et al, 1998) has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effects ofTeucrium polium. on Some Established Cell Lines

Nematollahi-Mahani

Rezazadeh-Kermani

Mehrabani

et al. 2007

Pharmaceutical Biology

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Teucrium polium (Lamaceae), part of the natural flora of Iran and the Middle East, has long been used for the treatment of diabetes, gastric inflammation, and convulsion in traditional medicine (Reishinger, 1982). Although some benefits of T. polium have been claimed by researchers, very few studies have investigated the cytotoxic effects of this herb. In the current study, we investigated the cytotoxic effects of an ethanol extract of T. polium on four cell lines, A549, BT20, MCF7, and PC12, by measurement of mitochondrial respiration as well as colony-forming assay. We also compared T. polium cytotoxicity to paclitaxel, a known herbal anticancer agent. Our results show that the ethanol extract of T. polium suppressed the growth of all tested cell lines effectively. The IC 50 values for each cell line were calculated as follows: A549, 90 mg=mL; BT20, 106 mg=mL; MCF-7, 140 mg=mL; and PC12, 120 mg=mL. T. polium extract also inhibited formation of colonies in agarose efficiently. Further investigations are now needed to establish the exact mechanism of action and identify the active ingredient(s) of T. polium extract in order to show its therapeutic efficacy.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic Effects ofTeucrium polium. on Some Established Cell Lines

Nematollahi-Mahani

Rezazadeh-Kermani

Mehrabani

et al. 2007

Pharmaceutical Biology

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“…Its extract has been shown to induce hypotensive (7), anti-inflammatory (8), hypoglycemic (9), antispasmodic (10), antibacterial and antipyretic (11) effects. Most of these effects have been related to the antioxidant and free radical scavenging properties of Teucrium polium (12).…”

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confidence: 99%

Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats

Panovska

Kulevanova

Gjorgoski³

et al. 2007

Acta Pharmaceutica

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Hepatoprotective activity of the ethyl acetate extract of Teucrium polium L. was investigated using rats with CCl 4 --induced liver damage. Specific biochemical parameters (glutathione peroxidase, superoxide dismutase, reduced glutathione and total antioxidative status) were estimated in blood and in liver homogenate. Lipid peroxidation in CCl 4 -intoxicated rats was evidenced by a marked increment in the levels of thiobarbituric acid reactive substances. Histopatological examinations of the liver were undertaken to monitor the liver status. Silymarin was used as a standard to compare the hepatoprotective activity of the extract. Some biochemical parameters in groups treated with the Teucrium polium extract at a dose of 25 mg kg -1 , showed significantly different values than that of the CCl 4 -treated group. The liver biopsy of all experimental rat groups treated with the Teucrium polium ethyl acetate extract showed significant restoration of the normal histomorphological pattern of liver cells. The study substantiates the potential hepatoprotective activity of the ethyl acetate extract of Teucrium polium L.

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“…Some members of the genus Teucrium such as T. polium have been used for their anti-inflammatory and antibacterial effect. 28 Sarac and Ugur 29 demonstrated the antimicrobial activities of the ethanolic toxicity of S. sclarea could be explained by the fact that the plant was cultivated outside its normal geographical distribution. These results indicate that the V. fischeri bioluminescence inhibition bioassay is suitable at least for screening herbs for their bactericide properties.…”

Section: Methodsmentioning

confidence: 99%