Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum burmannii (Nees &amp; T. Nees) Blume from Lombok Timur Indonesia

Budiastuti,; Nurcholida, Rosy Dwi; Primaharinastiti, Riesta; Sukardiman,

doi:10.5530/pj.2021.13.130

Cited by 8 publications

(13 citation statements)

References 12 publications

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“…The anti-inflammatory effects of the leaf essential oil of Cinnamomum subavenium were evaluated by LPS-stimulated RAW264.7 cells, and the levels of proinflammatory mediators, such as TNF-𝛼, IL-1𝛽 and IL-6, which were considerably increased by LPS, were significantly decreased by the essential oil [ 37 ]. Similar findings were reported in the case of Cinnamomum burmannii bark oil [ 40 ] and leaf oil of Cinnamomum cassia [ 42 ]. The findings of the present investigation are consistent with those of similar studies performed on RAW 264.7 cells, wherein plant essential oils were reported to suppress the production of proinflammatory cytokines generated by LPS [ 13 , 74 , 75 ].…”

Section: Resultssupporting

confidence: 89%

“…Although no reports have been published on the anti-inflammatory activities of essential oil of any Neocinnamomum species to date, the essential oils of several species of its closely related genus, Cinnamomum , are potent anti-inflammatory agents [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Therefore, it is expected that the essential of oil Neocinnamomum species might have similar anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

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Neocinnamomum caudatum Essential Oil Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Cells by Inhibiting NF-κB Activation and ROS Production

et al. 2022

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Neocinnamomum caudatum (Lauraceae) plant is used in the traditional system of medicine and is considered a potential source of edible fruits, spices, flavoring agents and biodiesel. The leaves, bark and roots of the species are used by local communities for the treatment of inflammatory responses, such as allergies, sinusitis and urinary tract infections. However, there is no scientific evidence to support the molecular mechanism through which this plant exerts its anti-inflammatory effect. The aim of the current research was to characterize the chemical constituents of bark (NCB) and leaf (NCL) essential oil of N. caudatum and to elucidate its anti-inflammatory action in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Essential oils extracted by hydrodistillation were further subjected to gas chromatography mass spectrometry (GC-MS) analysis. The major constituents in bark essential oil identified as β-pinene (13.11%), α-cadinol (11.18%) and α-pinene (10.99%), whereas leaf essential oil was found to be rich in β-pinene (45.21%), myrcene (9.97%) and α-pinene (9.27%). Treatment with NCB and NCL at a concentration of 25 µg/mL exerted significant anti-inflammatory activity by significantly reducing LPS-triggered nitric oxide (NO) production to 45.86% and 61.64%, respectively, compared to the LPS-treated group. In the LPS-treated group, the production of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, decreased after treatment with essential oil, alleviating the mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. The essential oil also inhibited the production of intracellular ROS and attenuated the depletion of mitochondrial membrane potential in a concentration-dependent manner. Pretreatment with NCB also reduced nuclear factor kappa-B (NF-κB)/p65 translocation and elevated the levels of endogenous antioxidant enzymes in LPS-induced macrophages. The present findings, for the first time, demonstrate the anti-inflammatory potential of both bark and leaf essential oils of N. caudatum. The bark essential oil exhibited a significantly more important anti-inflammatory effect than the leaf essential oil and could be used as a potential therapeutic agent for the treatment of inflammatory diseases.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Neocinnamomum caudatum Essential Oil Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Cells by Inhibiting NF-κB Activation and ROS Production

et al. 2022

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“…2020 ). Bioactive compounds of C. burmannii consist of eugenol, coumarin and cinnamaldehyde ( Budiastuti et al . 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Blood Glucose Level, Langerhans Pancreas and Lipid Profile of Diabetic Rats After Administration of Red Betel, Ginger and Cinnamon Combination Extract

Safithri

Bintang

Syaefudin

2023

tlsr

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Previous studies had reported antihyperglycemic activity in vitro, in vivo and in silico of red betel (Piper crocatum) extract, which was associated with its polyphenolic, tannins, alkaloids, and flavonoids compounds. This study aimed to determine blood glucose level, Langerhans pancreas, lipid profile and bodyweight of streptozotocin-induced diabetic rats after administrating red betel combination extract. Red betel combination extract is composed of red betel extract that was combined with ginger and cinnamon extracts. 16 male rats (Sprague Dawley) were divided randomly into two controls groups (Normal and diabetic groups; orally administered with 2 mL of aquadest for 14 days) and two extract groups (diabetic groups; orally administered with red betel combination extract 9 mL/kg BW and 13.5 mL/kg BW). Results showed that the administration of red betel combination extract for 14 days (9 mL/kg BW dosage) decreased the rat’s blood glucose level up to 55.42%, which was significantly different (p < 0.05) compared to the rat’s blood glucose levels on day 3. While the combination extract (dosages 9 mL/kg BW and 13.5 mL/kg BW) increased the numbers of rat Langerhans islets up to 10.9%–30.6%. The level of rat’s blood high-density lipoprotein (HDL) and triglyceride levels in the diabetic control group were significantly different (p < 0.05) compared to that of the diabetic with red betel combination extract and normal groups. The treatment orally with red betel combination extract (various dosages) for 14 days suppressed the weight loss of rats by 10%–11%.

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“…A certificate of authenticity for the bark of C. zeylanicum was obtained from CSIR-NISCAIR (New Delhi, India), and the hydro-methanolic extract of powdered bark was prepared as described previously ( Budiastuti et al, 2021 ). Briefly, coarse powder of the bark was incubated overnight with 50% ethanol in an orbital incubator shaker.…”

Section: Methodsmentioning

confidence: 99%

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

et al. 2022

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Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have elucidated the anti-tumor effects of Cinnamomum zeylanicum extract (CZE) and its bioactive compound cinnamaldehyde (CIN) on oral cancer and elucidated underlying molecular mechanisms. Anti-tumor activities of CZE and CIN were demonstrated by various in vitro experiments on oral cancer cells (SCC-4, SCC-9, SCC-25). The cell proliferation, growth, cell cycle arrest, apoptosis, and autophagy were analyzed by MTT, clonogenic assay, propidium iodide, annexin-V-PI, DAPI, and acridine orange staining, respectively. The binding affinity of CIN towards dihydrofolate reductase and p38-MAP kinase alpha was analyzed by molecular docking. Western blot assay was performed to assess the alteration in the expression of various proteins. CZE and CIN treatment significantly inhibited the growth and proliferation of oral cancer cells in a dose-dependent manner. These treatments further induced apoptosis, cell cycle arrest, and autophagy. CZE and CIN inhibited the invasion and cytoplasmic translocation of NF-κB in these cell lines. CIN showed a high affinity to MAP kinase P38 alpha and dihydrofolate reductase with binding affinities of −6.8 and −5.9 kcal/mol, respectively. The cancer cells showed a decreased expression of various PI3k-AKT-mTOR pathways related to VEGF, COX-2, Bcl-2, NF-κB, and proteins post-treatment.

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Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum burmannii (Nees & T. Nees) Blume from Lombok Timur Indonesia

Cited by 8 publications

References 12 publications

Neocinnamomum caudatum Essential Oil Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Cells by Inhibiting NF-κB Activation and ROS Production

Neocinnamomum caudatum Essential Oil Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Cells by Inhibiting NF-κB Activation and ROS Production

Blood Glucose Level, Langerhans Pancreas and Lipid Profile of Diabetic Rats After Administration of Red Betel, Ginger and Cinnamon Combination Extract

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

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