Anti-inflammatory activity of caffeic acid derivatives from Ilex rotunda

Kim, Chang‐Kwon; Yu, Jayeon; Le, DucDat; Han, Sanghee; Yu, Soojung; Lee, Mina

doi:10.1016/j.intimp.2022.109610

Cited by 11 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, supplementation of weaned piglets with Xiasangju residues significantly reduced the diarrhea score of the piglets. The reduction in diarrhea in weanling piglets caused by Xiasangju residues may be due to the presence of lutein, caffeic acid, and chlorogenic acid, which inhibit pathogenic bacteria ( Köksal et al., 2017 ; Sun et al., 2022 ; Zhang et al., 2022 ), are anti-inflammatory and improve the intestinal barrier ( Naveed et al., 2018 ; Kim et al., 2023 ), as also confirmed in this study.…”

Section: Discussionsupporting

confidence: 82%

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets

Sun,

Chen,

Huang

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Weaning stress can induce diarrhea, intestinal damage and flora disorder of piglets, leading to slow growth and even death of piglets. Traditional Chinese medicine residue contains a variety of active ingredients and nutrients, and its resource utilization has always been a headache. Therefore, we aimed to investigate the effects of traditional Chinese medicine residues (Xiasangju, composed of prunellae spica, mulberry leaves, and chrysanthemum indici flos) on growth performance, diarrhea, immune function, and intestinal health in weaned piglets. Forty-eight healthy Duroc× Landrace × Yorkshire castrated males weaned aged 21 days with similar body conditions were randomly divided into 6 groups with eight replicates of one piglet. The control group was fed a basal diet, the antibiotic control group was supplemented with 75 mg/kg chlortetracycline, and the residue treatment groups were supplemented with 0.5%, 1.0%, 2.0% and 4.0% Xiasangju residues. The results showed that dietary Xiasangju residues significantly reduced the average daily feed intake, but reduced the diarrhea score (P < 0.05). The 1.0% and 2.0% Xiasangju residues significantly increased the serum IgM content of piglets, and the 0.5%, 1.0%, 2.0% and 4.0% Xiasangju residues significantly increased the serum IgG content, while the 1.0%, 2.0% and 4.0% Xiasangju residues significantly increased the sIgA content of ileal contents (P < 0.05). Dietary Xiasangju residues significantly increased the villus height and the number of villus goblet cells in the jejunum and ileum, and significantly decreased the crypt depth (P<0.05). The relative mRNA expression of IL-10 in the ileum was significantly increased in the 1% and 2% Xiasangju residues supplemented groups (P < 0.05), while IL-1β in the ileum was downregulated (P < 0.05). Xiasangju residues improved the gut tight barrier, as evidenced by the enhanced expression of Occludin and ZO-1 in the jejunum and ileum. The diets with 1% Xiasangju residues significantly increased the relative abundance of Lactobacillus johnsonii, and 2% and 4% Xiasangju residues significantly increased the relative abundance of Weissella jogaeotgali (P < 0.05). Dietary supplementation with 0.5%, 1.0%, 2% and 4% with Xiasangju residues significantly decreased the relative abundance of Escherichia coli and Treponema porcinum (P < 0.05). In summary, dietary supplementation with Xiasangju residues improves intestinal health and gut microbiota in weaned piglets.

show abstract

Section: Discussionsupporting

confidence: 82%

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets

Sun,

Chen,

Huang

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Thus, the glucosidation at C-3 might be favorable to inhibiting IL-8 production. Compounds (16)(17)(18) have the same quercetin backbone. Compound 16 contained 3-rhamnoside, showing a better inhibitory effect than those of 17 and 18.…”

Section: Discussionmentioning

confidence: 99%

“…Three total extracts were analyzed using our previous method [18] with a slight modification. Particularly, mobile phase elution of a gradient solvent system consisted of channel A (pure water containing 0.1% formic acid) and channel B (acetonitrile, 0.1% formic acid) as follows: 5-15% (B) for 0-4 min, 4-35% (B) for 4-12 min, 35-45% (B) for 12-17 min, 45-100% (B) for 17-23 min and held for three minutes, and 100-5% (B) for 1 min before re-equilibrium with 5% (B).…”

Section: Lc-ms/ms Conditions and Molecular Network Experimentsmentioning

confidence: 99%

Molecular Networking and Bioassay-Guided Preparation and Separation of Active Extract and Constituents from Vicia tenuifolia Roth

Le,

Yu,

Dang

et al. 2023

Antioxidants

Self Cite

View full text Add to dashboard Cite

Molecular networking drove the selection of material from V. tenuifolia organs that targeted active flavonoid glycosides. To optimize the extraction process, the flowers of V. tenuifolia were used to produce an anti-inflammatory extract. The effects of variables—organic solvent ratio; extraction time; and temperature—were investigated by the response of anti-inflammatory activity. Bioactivities-guided experiments helped identify fractions with high total phenolic and flavonoid content as well as antioxidant potential. Furthermore, one new compound (1), 19 first isolated together, and two known compounds were obtained and identified from the active fraction of this plant. Among them, compounds (15 and 22) were first reported for nuclear magnetic resonance (NMR) data from this study. All the isolates were evaluated for their anti-inflammatory capacity throughout, modulating nitric oxide (NO), interleukin (IL)-1β, and IL-8 production. Active compounds were further investigated for their regulation and binding affinity to the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins by Western blot and in silico approaches, respectively. The findings of this study suggested that the developed extract method, active fraction, and pure components should be further investigated as promising candidates for treating inflammation and oxidation.

show abstract

“…In this regards, Caffeic acid (CA), the famous phenolic compound found in daily dietary tea and coffee has been used as a powerful radical scavenger due to its hydrogen-donating [19,20]. Moreover, it has been reported as an e cient antioxidant [21], anti-in ammatory [22], antidiabetic [23], and cardioprotective [24].…”

mentioning

confidence: 99%

The Hepatorenal protective potential of caffeic acid consumption on the Arsenic-exposed Syrian mice

Chekneh,

Azadi,

Baghshani

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of Caffeic acid was investigated in Arsenic-exposed Syrian mice. Methods 24 male Syrian mice (30 \(\pm\)8 g) were provided and randomly divided into 4 groups of 6 receiving Nothing, Arsenic, Arsenic & caffeic, and caffeic acid. The mice passed the 21-day treatment program. The mice's blood was collected and analyzed by measuring the serum ALT/AST enzymes and Creatinine/Urea levels, respectively. Finally, the histopathological properties in both the kidney and liver organs of the mice were studied. Results Arsenic Administration significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), LDH, urea, and creatinine concentrations (p < 0.05). Simultaneous administration of caffeic acid with arsenic decreased the serum AST and creatinine (p < 0.05). Moreover, the renal glomerulus and liver regeneration in the mice receiving caffeic acid supplements exhibited the caffeic acid hepatorenal protective potential. Conclusion The histopathological changes caused by arsenic in the mice's liver and kidney tissue including degeneration, necrosis, hyperemia, and tissue hypotrophy were shifted to normal conditions following the Caffeic acid administration dose, which was verified by the mice blood biochemical analysis results.

show abstract

Anti-inflammatory activity of caffeic acid derivatives from Ilex rotunda

Cited by 11 publications

References 38 publications

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets

Molecular Networking and Bioassay-Guided Preparation and Separation of Active Extract and Constituents from Vicia tenuifolia Roth

The Hepatorenal protective potential of caffeic acid consumption on the Arsenic-exposed Syrian mice

Contact Info

Product

Resources

About