Anti-Inflammatory Activity of Benzoxazinoids from Roots of Coix lachryma-jobi var. Ma-yuen

Abstract

The anti-inflammatory activities of six benzoxazinoids isolated from roots of Coix lachryma-jobi var. ma-yuen and structurally related synthetic materials were investigated by measurement of their inhibition of histamine release from rat mast cells stimulated with concanavalin A (Con A) and sensitized with immunoglobulin E (reagin). Because the inhibition data for either Con A or IgE with these compounds were comparable, Con A can be used for rapid first-stage screening of active compounds. Four glycosides out of the eleven compounds investigated were not active. Other results showed that the free hydroxyl group at the 2-position in the benzoxazinone skeleton is important for the expression of inhibitory activity.

Megastigmane, aliphatic alcohol and benzoxazinoid glycosides from Acanthus ebracteatus

“…The HMBC correlations of compound 5. 9) and phenylpropanoids (14-15) as the major constituents are in agreement with Thai traditional usage as an anti-inflammatory preparation (Otsuka et al, 1988;Cometa et al, 1993). Furthermore, the toxicological and pharmacological properties of benzoxazinoids have been reported as the chemical resistance factors against insects, fungi, bacteria and viruses in many crop plants of the family Gramineae (Niemeyer, 1988;Sicker et al, 2000), as well as having mutagenic activities (Hashimoto and Shudo, 1996).…”

Effects of adlay hull extracts on uterine contraction and Ca2+mobilization in the rat

“…It has been reported that AHM possesses some low-molecular-weight and moderately polar substances that have antioxidative effects (23). Moreover, at least of the following six classes of chemical constituents of AHM have been demonstrated: lignan, phenolic acid, phytosterols, polyphenols, polysaccharides, and flavonoids (15,22,34,43). In our previous study (15), we quantified the components of the AHM-EA fraction; it contained naringenin, quercetin, vanillin, syringaldehyde, gallic acid, syringic acid, and p-coumaric acid.…”

Peroxisome Proliferator-Activated Receptor .GAMMA. Ligands Isolated from Adlay Seed (Coix lacryma-jobi L. var. ma-yuen STAPF.)

“…[8][9][10][11][12] Some active compounds previously isolated from the adlay seed include coixenolides that possess anti-tumor effects, 13) coixans A, B, and C that possess hypoglycemic effects, 14) and benzoxazinones that possess anti-inflammatory effects. 15) In our search for novel PPARg agonists, we selected 88 herbal crude drugs that are frequently used in Kampo medicines. Compounds isolated from the adlay seed extract showed relatively high PPARg agonist activity and the structures of the active compounds were determined to be hydroxy unsaturated fatty acids.…”