Anti-Inflammatory Activity of Acetophenones from<i>Ophryosporus axilliflorus</i>

Favier, Laura S.; Tonn, Carlos E.; Guerreiro, Eduardo; Rotelli, Alejandra Ester; Pelzer, Lilian Eugenia

doi:10.1055/s-2006-957543

Cited by 31 publications

(23 citation statements)

References 5 publications

(7 reference statements)

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“…A. inulifolium se utiliza como anticonceptivo, emenagogo y abortivo, B. salicifolia presenta actividad antileishmaniasis, insecticida, antimicrobiana, antirreumática, antiinflamatoria, antiséptica y astringente, en tanto que O. axilliflorus es analgésica, antisifilítica, astringente y dermopática. En general, estas especies presentan compuestos químicos entre los cuales se destacan flavonoides, terpenos, lactonas y cromonas, (Jakupovic et al, 1990;Favier et al, 1998;Freire & Urtubey, 1999;Nuñez & Cantero, 2000). A pesar de su potencial farmacobotánico, no existen investigaciones anatómicas o histoquímicas de estas especies.…”

Section: Introductionunclassified

Morfoanatomía e histoquímica de cuatro Asteraceae nativas del Bosque Chaqueño Serrano (Córdoba, Argentina)

Tosoratto¹,

Cosa²,

Delbón³

2016

Bol. Soc. Argent. Bot.

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Summary: Morfoanatomy and histochemistry in Asteraceae native from Chaco Serrano Forest (Córdoba, Argentina). Chaco Serrano Forest is characterized by a semiarid climate; the species that live there have modifications related mainly to water balance. In this habitat the Asteraceae family is one of the largest, concentrating large numbers of species with medicinal properties. Four of them were studied in this work, they are: Austroeupatorium inulifolium, Baccharis salicifolia, Chromolaena hookeriana and Ophryosporus axilliflorus. We inquired about air vegetative organs in order to understand the adaptive strategies presented in relation to the environment in which they live, detect active producing structures and infer the chemicals they produce. In the four studied species xeromorphic features were observed, including the presence of trichomes, ducts and endodermis with Caspary band in the stem. Also they were positive in pectic and lipid compounds test and B. salicifolia presented tannins in the epidermis. We conclude that the secretory structures and chemicals found were directly related to the medicinal properties of these species.Key words: Austroeupatorium inulifolium, Baccharis salicifolia, Chromolaena hookeriana, Ophryosporus axilliflorus, secretory duct, trichomes, endodermis, Caspary band.Resumen: El Bosque Chaqueño Serrano se caracteriza por un clima semiárido; las especies que habitan en él presentan una serie de modificaciones relacionadas principalmente al balance hídrico. En este hábitat la familia Asteraceae es una de las más numerosas, nucleando gran cantidad de especies con propiedades medicinales. Cuatro de ellas fueron estudiadas en el presente trabajo, ellas son: Austroeupatorium inulifolium, Baccharis salicifolia, Chromolaena hookeriana y Ophryosporus axilliflorus. Se indagó sobre los órganos vegetativos aéreos con el objetivo de comprender las estrategias adaptativas que presentan en relación al ambiente en que viven, detectar estructuras productoras de principios activos e inferir los compuestos químicos que ellas producen. En las cuatro especies estudiadas se observaron características consideradas xeromórficas, destacándose la presencia de tricomas, conductos y endodermis con banda de Caspary en los tallos. Además, resultaron positivas para las pruebas de compuestos pécticos y lipídicos y B. salicifolia presentó taninos en la epidermis. Concluimos que las estructuras secretoras y los compuestos químicos encontrados estarían directamente relacionados con las propiedades medicinales de estas especies.

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Section: Introductionunclassified

Morfoanatomía e histoquímica de cuatro Asteraceae nativas del Bosque Chaqueño Serrano (Córdoba, Argentina)

Tosoratto¹,

Cosa²,

Delbón³

2016

Bol. Soc. Argent. Bot.

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“…Phenolic compounds or polyphenols, which consist of secondary vegetal metabolites, constitute a wide and complex array of phytochemicals that exhibit antioxidant action (9). Among the phenolic compounds, some acetophenones possess several biological properties (10). It has been reported by Mathiesen and collaborators (11) that phloroacetophenone (2′,4′,6′-trihydroxyacetophenone – THA; Fig.…”

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confidence: 99%

Potent hepatoprotective effect in CCl₄-induced hepatic injury in mice of phloroacetophenone fromMyrcia multiflora

Ferreira

Gris

Correia

et al. 2010

Libyan Journal of Medicine

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BackgroundThis study investigated the hepatoprotective effect and antioxidant properties of phloroacetophenone (2′,4′,6′-trihydroxyacetophenone – THA), an acetophenone derived from the plant Myrcia multiflora.Material & MethodThe free radical scavenging activity in vitro and induction of oxidative hepatic damage by carbon tetrachloride (CCl4) (0.5 ml/kg, i.p.) were tested in male Swiss mice (25±5 g).ResultsThis compound exhibited in vitro antioxidant effects on FeCl2–ascorbate-induced lipid peroxidation (LPO) in mouse liver homogenate, scavenging hydroxyl and superoxide radicals, and 2,2-diphenyl-1-picrylhydrazyl. The in vivo assays showed that THA significantly (p<0.01) prevented the increases of hepatic LPO as measured by the levels of thiobarbituric acid-reactive substances, mitochondrial swelling. It also protected hepatocytes against protein carbonylation and oxidative DNA damage. Consistent with these observations, THA pre-treatment normalized the activities of antioxidant enzymes, such as catalase, glutathione peroxidase, and superoxide dismutase, and increased the levels of reduced glutathione (GSH) in CCl4-treated mice. In addition, THA treatment significantly prevented the elevation of serum enzymatic activities of alanine amino transferase, aspartate amino transferase, and lactate dehydrogenase, as well as histological alterations induced by CCl4. Silymarin (SIL) (24 mg/kg), a known hepatoprotective drug used for comparison, led to a significant decrease (p<0.01) in activities of theses enzymes in way very similar to that observed in pre-treatment with THA.ConclusionThese results suggest that the protective effects are due to reduction of oxidative damage induced by CCl4 resulting from the antioxidant properties of THA.

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“…Structures were determinate by EM, 1 H y 13 C-RMN ( The anti-inflammatory activity of all the extracts has been evaluated by paw edema test [4] ( Table 2). …”

Section: Resultsmentioning

confidence: 99%

Phytochemical Study Conyza Sophiaefolia. Antiinflammatory Activity

et al. 2000

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Anti-Inflammatory Activity of Acetophenones fromOphryosporus axilliflorus

Cited by 31 publications

References 5 publications

Morfoanatomía e histoquímica de cuatro Asteraceae nativas del Bosque Chaqueño Serrano (Córdoba, Argentina)

Morfoanatomía e histoquímica de cuatro Asteraceae nativas del Bosque Chaqueño Serrano (Córdoba, Argentina)

Potent hepatoprotective effect in CCl₄-induced hepatic injury in mice of phloroacetophenone fromMyrcia multiflora

Phytochemical Study Conyza Sophiaefolia. Antiinflammatory Activity

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Anti-Inflammatory Activity of Acetophenones fromOphryosporus axilliflorus

Cited by 31 publications

References 5 publications

Morfoanatomía e histoquímica de cuatro Asteraceae nativas del Bosque Chaqueño Serrano (Córdoba, Argentina)

Morfoanatomía e histoquímica de cuatro Asteraceae nativas del Bosque Chaqueño Serrano (Córdoba, Argentina)

Potent hepatoprotective effect in CCl4-induced hepatic injury in mice of phloroacetophenone fromMyrcia multiflora

Phytochemical Study Conyza Sophiaefolia. Antiinflammatory Activity

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Potent hepatoprotective effect in CCl₄-induced hepatic injury in mice of phloroacetophenone fromMyrcia multiflora