Anti-inflammatory activity of a Vernonia cinerea methanolic extract in vitro

Saraphanchotiwitthaya, Aurasorn; Sripalakit, Pattana

doi:10.2306/scienceasia1513-1874.2015.41.392

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…is a plant in Family Asteraceae. It has several activities such as antioxidant activity [1–5], anti-inflammatory activity [6, 7], and radioprotective activity [8]. Furthermore, it also has antitumor activity, antimicrobial activity, antidiabetic activity, etc.…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature and Duration Time of Maceration on Nitrate Content of Vernonia cinerea (L.) Less.: Circumscribed Central Composite Design and Method Validation

Monton

Luprasong

2019

International Journal of Food Science

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Vernonia cinerea (L.) Less. is a herbal plant in Family Asteraceae. It can be used as a smoking cessation aid due to the fact that it contains nitrate which can induce tongue numbness and cause less favor of cigarette smell and taste. The aim of this work was to investigate the effect of maceration temperature and time on the nitrate content of V. cinerea. A circumscribed central composite experimental design was applied in the work. Two factors (temperature and duration time) were investigated and two responses (yield of the extraction and nitrate content) were monitored. The high performance liquid chromatography using for quantitative analysis of nitrate content was validated. The HPLC response was linear (R2 = 1.000) in range of 10-100 μg/mL. The HPLC method was specific, precise, and accurate. The maceration temperature and time were varied from 40 to 100°C and 10 to 60 min, respectively. Results showed that maceration at high temperature and long duration time gave the simultaneous high yield of the extraction and nitrate content. The prediction by the computer software, Design-Expert, was stable, reliable, and accurate. The optimal condition that provided simultaneous high yield of the extraction and nitrate content was achieved when extraction was at 99.5°C for 56.4 min. V. cinerea extracted using the optimal condition gave the yield of the extraction and nitrate content of 15.6% and 0.610%, respectively. In conclusion, maceration temperature and duration time had a positive effect on yield of the extraction and nitrate content of V. cinerea. Furthermore, the optimal condition in this work could be used as a guide for extraction of V. cinerea to obtain the high yield of the extraction as well as nitrate content.

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Section: Introductionmentioning

confidence: 99%

Effect of Temperature and Duration Time of Maceration on Nitrate Content of Vernonia cinerea (L.) Less.: Circumscribed Central Composite Design and Method Validation

Monton

Luprasong

2019

International Journal of Food Science

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“…Both plants had strong anti-inflammatory properties. A previous study reported that CC extract significantly inhibited the secretion of IFN-γ in a dose-dependent fashion, while IL-10 anti-inflammatory cytokine increased [ 48 ]. Identified isothiocyanates from MO leaf extract significantly decreased gene expression and production of inflammatory mediators in RAW macrophages [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Cyanthillium cinereum (Less) H. Rob. Lozenges in Volunteer Smokers

Luetragoon

Sranujit

Noysang

et al. 2021

Plants

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Smokers have high plaque accumulation that initiates gingival inflammation and progresses to periodontitis. Thus, oral hygiene to control microbial plaque formation is an effective method of preventing gingivitis. Medicinal plants such as Moringa oleifera Lam. (MO) and Cyanthillium cinereum (Less.) H. Rob. (CC) have an anti-inflammatory effect that might improve oral health in smokers. This study evaluated the effect of MO leaf and CC extracts using MO lozenges and a combination of MO + CC lozenges on oral inflammation and gingivitis in volunteer smokers. Lozenges consisting of MO and CC extracts were developed and studied in vivo. The results showed that lozenges significantly reduced oral inflammation and gingivitis in volunteers. The gingival index (GI) of group III (MO + CC lozenges) significantly decreased, while the percentage decrease of oral inflammation in group II (MO lozenges) was significantly higher than the other groups. The percentage decrease of GI values in group II (MO lozenges) and group III (MO + CC lozenges) were significantly higher than the placebo group I. Our findings indicated that MO and MO + CC lozenges reduced oral inflammation and gingivitis and showed potential to improve oral health in smokers.

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“…These cytokines contribute to the pathogenesis and maintenance of the usual neuropathy presented in diabetic patients, promoting nervous excitability and therefore, inducing pain. [91][92][93] As for the antimicrobial activity of eugenol, there is a general idea about its action mechanism, which relates to the alteration of its permeability mechanism by damaging and altering lysosome, microsome, and cell walls. This damage causes bacterial death by the leakage of its essential cell constituents.…”

Section: Eugenolmentioning

confidence: 99%

Electrospun and co-electrospun biopolymer nanofibers for skin wounds on diabetic patients: an overview

et al. 2021

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Anti-inflammatory activity of a Vernonia cinerea methanolic extract in vitro

Cited by 12 publications

References 33 publications

Effect of Temperature and Duration Time of Maceration on Nitrate Content of Vernonia cinerea (L.) Less.: Circumscribed Central Composite Design and Method Validation

Effect of Temperature and Duration Time of Maceration on Nitrate Content of Vernonia cinerea (L.) Less.: Circumscribed Central Composite Design and Method Validation

Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Cyanthillium cinereum (Less) H. Rob. Lozenges in Volunteer Smokers

Electrospun and co-electrospun biopolymer nanofibers for skin wounds on diabetic patients: an overview

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