Anti-inflammatory activities, triterpenoids, and diarylheptanoids of<i>Alnus acuminata</i>ssp.<i>arguta</i>

Aguilar, María Isabel; Rovelo, Ricardo; Verjan, Juan G; Illescas, Oscar; Baeza, Ana E; Fuente, Marcela De La; Avila, Ileana; Navarrete, Andrés

doi:10.3109/13880209.2011.564634

Cited by 10 publications

(11 citation statements)

References 37 publications

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“…The bark of Myrica rubra contains flavonoids, tannins, triterpenes, and diarylheptanoids . Diarylheptanoids are used not only as food flavoring agents but also as medicines because of their many beneficial properties, including antitumor (Ishida et al, 2000), antiviral (Konno et al, 2011), antioxidant (Tao et al, 2008), and anti-inflammatory (Aguilar et al, 2011). Medicinal chemists and pharmaceutical researchers have recently focused on natural plants.…”

Section: Introductionmentioning

confidence: 99%

Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells

Dai¹,

Meng

Tong³

et al. 2014

Phytomedicine

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Section: Introductionmentioning

confidence: 99%

Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells

Dai¹,

Meng

Tong³

et al. 2014

Phytomedicine

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“…Previous studies have reported that Alnus plants possess a variety of terpenoids, flavonoids, polyphenols, steroids, and tannins, besides. Numerous bioactivities of genus Alnus were reported, including hepato-protective, antioxidant, and antitumor activities [26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract

Ryu

Sung

et al. 2020

Molecules

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JNK and p38 are important mitogen-activated protein kinases (MAPKs) that respond to stress stimuli. The stress-activated MAPKs associated with apoptotic cell death play vital roles in mammalian cells. Alnus hirsuta, which contains abundant diarylheptanoids derivatives, is a valuable medicinal plant. The CHCl3 extract (AHC) containing platyphyllenone (1) and platyphyllone (3) as main compounds showed in vitro anticancer effects. We report the biological activities of A. hirsuta extract associated with the regulation of apoptosis and JNK and p38 in MCF-7 breast cancer cells. Levels of phospho-JNK and phospho-p38 by AHC treatment were evaluated by enzyme-linked immunosorbent assay (ELISA). ROS production, apoptotic effect, and DNA contents of the cells were measured by flow cytometry. The two diarylheptanoids 1 and 3 and the AHC extract exhibited cytotoxic effects on MCF-7 cells in MTT assay, with IC50 values of 18.1, 46.9, 260.0 μg/mL, respectively. AHC induced ROS generation and elevated the endogenous levels of phospho-JNK and phospho-p38. AHC resulted in apoptosis and cell cycle arrest. We suggest that the antitumor effect of A. hirsuta extract is achieved by apoptosis promotion and cell cycle arrest mediated by the activation of JNK and p38 signaling pathway via ROS generation.

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“…A total of 48 triterpenes (compound 201 – 248 ) shown in Figure 9 , Figure 10 and Figure 11 and Table 14 and Table 15 and six steroids (compounds 249 – 254 ) in Figure 12 were obtained from the genus Alnus . Most of triterpenes are isolated from flowers, leaves and barks of Alnus plants [ 8 , 30 , 55 , 56 , 57 ]. They can be assigned into two classes: tetracyclic triterpenes (compounds 201 – 223 ) and pentacyclic triterpenes (compounds 224 – 248 ).…”

Section: Chemical Constituentsmentioning

confidence: 99%

The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities

et al. 2017

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The genus Alnus (Betulaceae) is comprised of more than 40 species. Many species of this genus have a long history of use in folk medicines. Phytochemical investigations have revealed the presence of diarylheptanoids, polyphenols, flavonoids, terpenoids, steroids and other compounds. Diarylheptanoids, natural products with a 1,7-diphenylheptane structural skeleton, are the dominant constituents in the genus, whose anticancer effect has been brought into focus. Pure compounds and crude extracts from the genus exhibit a wide spectrum of pharmacological activities both in vitro and in vivo. This paper compiles 273 naturally occurring compounds from the genus Alnus along with their structures and pharmacological activities, as reported in 138 references.

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Anti-inflammatory activities, triterpenoids, and diarylheptanoids ofAlnus acuminatassp.arguta

Cited by 10 publications

References 37 publications

Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells

Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells

Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract

The Genus Alnus, A Comprehensive Outline of Its Chemical Constituents and Biological Activities

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