Anti-inflammatory activities of some brown marine algae in LPS-stimulated RAW 264.7 cells

Hwang, Joon-Ho; Oh, You-Sung; Lim, Sang-Bin

doi:10.1007/s10068-014-0116-2

Cited by 10 publications

(11 citation statements)

References 26 publications

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“…The decrease in LPS-induced NO production at 50 µg mL −1 to levels similar to those observed in untreated cells reveals the remarkable anti-inflammatory potential of this extract. In fact, the anti-inflammatory activity of the extract is considerable higher than reported for other macroalgae extracts, namely from Saccharina japonica [ 53 ] or Undaria pinnatifida [ 54 ]. To our knowledge, this is the first study reporting the anti-inflammatory activity of B. bifurcata .…”

Section: Resultsmentioning

confidence: 74%

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

et al. 2017

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Macroalgae have been seen as an alternative source of molecules with promising bioactivities to use in the prevention and treatment of current lifestyle diseases. In this vein, the lipophilic fraction of short-term (three weeks) cultivated Bifurcaria bifurcata was characterized in detail by gas chromatography–mass spectrometry (GC-MS). B. bifurcata dichloromethane extract was composed mainly by diterpenes (1892.78 ± 133.97 mg kg−1 dry weight (DW)), followed by fatty acids, both saturated (550.35 ± 15.67 mg kg−1 DW) and unsaturated (397.06 ± 18.44 mg kg−1 DW). Considerable amounts of sterols, namely fucosterol (317.68 ± 26.11 mg kg−1 DW) were also found. In vitro tests demonstrated that the B. bifurcata lipophilic extract show antioxidant, anti-inflammatory and antibacterial activities (against both Gram-positive and Gram-negative bacteria), using low extract concentrations (in the order of µg mL−1). Enhancement of antibiotic activity of drug families of major clinical importance was observed by the use of B. bifurcata extract. This enhancement of antibiotic activity depends on the microbial strain and on the antibiotic. This work represents the first detailed phytochemical study of the lipophilic extract of B. bifurcata and is, therefore, an important contribution for the valorization of B. bifurcata macroalgae, with promising applications in functional foods, nutraceutical, cosmetic and biomedical fields.

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Section: Resultsmentioning

confidence: 74%

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

et al. 2017

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“…The methodologies used in these studies were different from that used in the current study, in which the activity of the COX‐2 enzyme was reduced by inhibition. Some other species of brown seaweed, such as Undaria pinnatifida , have been said to promote anti‐inflammatory activity (Hwang et al ., ). This activity was also observed in an alcoholic extract.…”

Section: Discussionmentioning

confidence: 99%

Azorean macroalgae (Petalonia binghamiae, Halopteris scoparia and Osmundea pinnatifida) bioprospection: a study of fatty acid profiles and bioactivity

Campos

Matos

Afonso

et al. 2018

Int J of Food Sci Tech

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Summary The Azorean macroalgae Petalonia binghamiae, Halopteris scoparia and Osmundea pinnatifida are undervalued and require further study regarding their potential use as food. These three seaweed species had low fat contents, and their fatty acid (FA) profiles were characterised by a high proportion of saturated FA (SFA) in the case of O. pinnatifida and similar weights of SFA and polyunsaturated FA (PUFA) in the other two species. Within the PUFAs, the ω3 PUFAs were the most prominent in O. pinnatifida and P. binghamiae, yielding ω3/ω6 ratios that were higher than one. Eicosapentaenoic acid (EPA, 20:5 ω3) was the most important ω3 PUFA (10–14%). Regarding the other bioactive compounds, the polyphenols were found to reach non‐negligible levels (140–220 mg/100 g dw). Significant antioxidant activity was detected. Ethanolic extracts of H. scoparia and aqueous extracts of P. binghamiae showed cyclooxygenase‐2 (COX‐2) inhibitory capacities between 40% and 79%, indicating anti‐inflammatory activity.

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“…Since PPPs from SA and JD significantly decreased ROS ated in brown seaweed, Undaria pinnatifida using local strains collected from southeastern sea shores in Korea (Hwang et al 2014). The different antioxidant and antiinflammatory activities of the seaweeds in the three areas indicated differences chemical compositions and different inhabited areas (Sanjeewa et al 2019).…”

Section: Apoptotic Body Formation In Vero Cells Upon Treatment With Pmentioning

confidence: 99%

Protective effects of extracts from six local strains of <italic>Pyropia yezoensis</italic> against oxidative damage <italic>in vitro</italic> and in zebrafish model

Dai¹,

Kim²,

Kang³

et al. 2020

ALGAE

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Pyropia yezoensis has been used as functional food in East Asia, especially in Korea and Japan, for more than five hundred years. This study aims to evaluate the antioxidant effect of polyphenols and proteins-rich extracts from P. yezoensis (PPPs) against 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidative cell damage. Among six Korean local strains obtained from Jinhae (JiH), Haenam (HN), Jangheung (JaH), Jindo (JD), Wando (WD), and Sinan (SA) areas, the extracts of P. yezoensis from SA and JD are relatively higher in polyphenols and proteins contents. SA showed the lowest IC 50 scavenging activities against 1,1-diphenyl-2-picryl-hydrazyl and alkyl radicals and displayed protective effects against reactive oxygen species (ROS) in AAPH-induced Vero cells. Especially, the PPPs extracts from SA and JD showed protective activities against AAPH-induced apoptosis, as observed by nuclear staining with Hoechst 33342. Furthermore, in vivo studies of the SA extract in zebrafish showed significantly reduced ROS generation, lipid peroxidation, and cell damage. This is the first study, to our knowledge, to evaluate the antioxidant bioactivity of PPP in the Korean Peninsula using a zebrafish model. Due to SA and JD both located in the west coast of Korea, we deduced that the chemical content of the different PPP extracts was mildly influenced by their geographic location, and this alga has potential of protective activity against AAPH-induced ROS both in vitro and in vivo.

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Anti-inflammatory activities of some brown marine algae in LPS-stimulated RAW 264.7 cells

Cited by 10 publications

References 26 publications

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

Azorean macroalgae (Petalonia binghamiae, Halopteris scoparia and Osmundea pinnatifida) bioprospection: a study of fatty acid profiles and bioactivity

Protective effects of extracts from six local strains of <italic>Pyropia yezoensis</italic> against oxidative damage <italic>in vitro</italic> and in zebrafish model

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