Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs

Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis

“…(1) Herbal compounds could inhibit the binding and interactions of HMGB1 to its receptors. This concept was supported by the finding that herbal medicine blocks chemokine binding to its receptors [8][9][10][11][12][13][14]. (2) Herbal compounds could block the downstream signaling pathway of receptors activation by HMGB1; this is also supported by the finding that recently we showed that herbal compounds inhibited LPS-stimulated NF-κB activation which is the down-stream transcriptional factor of HMGB1 [8,11,[13][14][15][16][18][19][20][21][22].…”

“…This concept was supported by the finding that herbal medicine blocks chemokine binding to its receptors [8][9][10][11][12][13][14]. (2) Herbal compounds could block the downstream signaling pathway of receptors activation by HMGB1; this is also supported by the finding that recently we showed that herbal compounds inhibited LPS-stimulated NF-κB activation which is the down-stream transcriptional factor of HMGB1 [8,11,[13][14][15][16][18][19][20][21][22]. (3) Herbal compounds could enter cells and interact with proinflammatory intracellular kinases or signaling pathways such as NF-κB, c-Jun N-terminal kinases (JNK1/2) or signal transducer and activator of transcription 3 (STAT3) and inflammatory intracellular molecules such as interleukin-6 (IL-6), IL-8, monocyte chemoattractant protein 1 (MCP-1), TNF-α, IL-1β or atrogin-1.…”

“…We recently showed that herbal single compound down-regulated the cell surface expression of the three receptors, TLR-2, TLR-4, and RAGE, which are known to bind HMGB1 to initiate pro-inflammatory responses in endothelial cells [8][9][10][11][12][13][14]. Similar to HMGB1, LPS also upregulated the expression of all three receptors on endothelial cells, and single compound from herbal medicines down regulated this effect [8][9][10][11][12][13][14][15][16][17][18], suggesting that herbal compounds can inhibit the amplification of pro-inflammatory pathways propagated by LPS and HMGB1 during infections. There are several potential mechanisms by which herbal compounds could interfere with HMGB1 functions.…”

Anti-inflammatory effect of oleanoic acid 28-O--D-glycopyranosyl ester isolated from Aralia cordata in activated HMC-1 cells

“…Oleanolic acid, a natural pentacyclic triterpene widely found in a variety of plants, has been shown to display numerous biological properties with therapeutic potential (Dzubak et al, 2006;Liu, 2005;MartinezGonzalez et al, 2008). Recent reports have demonstrated anti-inflammatory effects of oleanoic acid by the modulation of high mobility group box 1(HMGB1)-dependent pro-inflammatory responses (Yang et al, 2012). But, no report has been issued on anti-inflammatory effect of OA, which has a sugar moiety in the oleanoic acid.…”

Tumour cell derived effects on monocyte/macrophage polarization and function and modulatory potential of Viscum album lipophilic extract in vitro

“…Amongst these, pentacyclic triterpenes have shown effects on tumours not only by inducing tumour cell apoptosis [16], but also by modulating the immune system and showing anti-angiogenic and anti-inflammatory activities in vitro and in vivo [17][18][19][20].…”