Anti-inflammatory activities of novel heat shock protein 90 isoform selective inhibitors in BV-2 microglial cells
Amanda G. Smith,
Valentin M. Kliebe,
Sanket Mishra
et al.
Abstract:Heat shock protein 90 (Hsp90) is a family of chaperone proteins that consists of four isoforms: Hsp90α, Hsp90β, glucose-regulated protein 94 (Grp94), and tumor necrosis factor type 1 receptor-associated protein (TRAP1). They are involved in modulating the folding, maturation, and activation of their client proteins to regulate numerous intracellular signaling pathways. Previous studies demonstrated that pan-Hsp90 inhibitors reduce inflammatory signaling pathways resulting in a reduction of inflammation and pai… Show more
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