Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips

Guo, De-Jian; Xu, Lijia; Cao, Xinwei; Guo, Yinlong; Yan, Yonghong; Chan, Chi-On; Mok, Daniel K. W.; Yu, Zhi‐Ling; Chen, Sibao

doi:10.1016/j.jep.2011.10.010

Cited by 51 publications

(22 citation statements)

References 33 publications

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“…The fruits and roots of some Rosa species are used as medicine and many studies reported that they had the pharmacological activities like anti-Helicobacter pylori, cytotoxic, multidrug resistance (MDR) reversal and radical scavenging, anti-HIV, antibacterial, antioxidant, antitussive, antidiabetic, anti-inflammatory and so on [2][3][4][5]. Rosa sericea is an ornamental plant which abundantly grows in the southwest of China.…”

Section: Introductionmentioning

confidence: 99%

Three new phenolic compounds from the leaves of Rosa sericea

Liu

et al. 2013

Fitoterapia

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Section: Introductionmentioning

confidence: 99%

Three new phenolic compounds from the leaves of Rosa sericea

Liu

et al. 2013

Fitoterapia

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“…The uses of Rose Hip scientifically reported so far are as functional food, antioxidant, osteoarthritis care, antiinflammatory, antidiabetic, cardioprotective, antimicrobial, immunomodulatory, gastroprotective and dermatological applications [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Healing incisional surgical wounds using Rose Hip oil in rats

Cavalcante¹,

Pessoa²,

Júnior³

et al. 2017

int arch med

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“…NO is a short-lived molecule that has an important role in various physiologic processes. However, NO overproduction can activate NF-κB to induce expression of proinflammatory mediators and can promote inflammation by increasing cyclic guanosine monophosphate, vascular permeability, and transmigration of inflammatory cells to inflammation sites [5,9]. NO toxicity increases considerably if it reacts with a superoxide radical; thereby, forming the highly reactive peroxynitrite anion, which leads to oxidative damage and tissue injury [22].…”

Section: Discussionmentioning

confidence: 99%

“…COX exists in two isoforms: COX-1 and COX-2. Selective inhibition of COX-2 has been suggested to be an approach for the treatment of inflammatory disorders [5]. LPS induces selective expression of COX-2, and dexamethasone selectively inhibits COX-2 expression [24].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of Rosa multiflora Thunb. flower extract and suppressive activity on proinflammatory mediator production in lipopolysaccharide- stimulated RAW 264.7 macrophages

Kwak

Choi²,

Yang³

2016

FFHD

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Background: Oxidative stress and inflammation are associated with various age-related chronic diseases. The fruits and roots of Rosa multiflora Thunb. have been used in medicine for the treatment of edema and inflammatory diseases in Eastern Asia. Dried Rosa multiflora Thunb. flowers (RMF) are consumed as a tea in Korea, but reports on the biological activity of RMF are lacking. We evaluated the in vitro antioxidant and anti-inflammatory effects of an ethanol extract from RMF as well as various solvent fractions from the extract. Methods:The ethanol extract (Et) of RMP was fractionated sequentially by hexane (Hx), dichloromethane (DM), ethyl acetate (EA), n-Butanol (Bt), and water (DW). Total phenolic and flavonoid contents, scavenging activities of the 2,2-diphenyl-1 picrylhydrazyl radical, 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical, and ferric-reducing antioxidant power were measured. Anti-inflammatory effects in terms of levels of nitric oxide (NO), prostaglandin (PG) E2, and production of pro-inflammatory cytokines such as interleukin (IL)-6, tumor necrosis factor (TNF)-α in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages were measured. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were measured by the Western blot analysis.Results: EA demonstrated the highest total phenolic and flavonoid contents and strongest antioxidant activity, followed by Bt and Et. Treatment with Et, Hx, DM, EA, Bt, and DW significantly suppressed (p<0.05) NO production in a dose-dependent manner in LPS-treated RAW 264.7 macrophages via reduction of expression of iNOS protein. Treatment with Et, DM, and EA significantly suppressed (p<0.05) PGE2 production induced by LPS treatment; however, only Bt treatment significantly reduced (p<0.05) the expression of COX-2 protein. Treatment with EA and Bt suppressed IL-6 production significantly (p<0.05) in LPS-treated RAW 264.7

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Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips

Cited by 51 publications

References 33 publications

Three new phenolic compounds from the leaves of Rosa sericea

Three new phenolic compounds from the leaves of Rosa sericea

Healing incisional surgical wounds using Rose Hip oil in rats

Antioxidant activity of Rosa multiflora Thunb. flower extract and suppressive activity on proinflammatory mediator production in lipopolysaccharide- stimulated RAW 264.7 macrophages

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