Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract

NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton

“…As shown in the right panel of Figure 2(a), only marginal inhibition (25%) by AP736 was observed at 30  μ M, indicating that AP736-mediated suppression of NO production is due to not only direct radical scavenging by AP736, but also other pharmacological mechanisms. We also confirmed that two control compounds, L-NAME (used in the NO assay) and indomethacin (used in the PGE 2 assay), exerted dose-dependent inhibition of NO release and PGE 2 secretion, respectively (Figure 2(c)), consistent with previous results [36]. Importantly, AP736 did not show any cytoxicity to RAW264.7 cells at concentrations up to 30  μ M at 8 and 24 h (Figure 2(d) left and right panels).…”

In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract

“…4C) strongly suggests that other flavonoid components with glycosides are also involved. In addition, we could also exclude luteolin, jaceosidin, and eupatilin, found in Artemisia asiatica ethanol extract (Aa-EE), exhibiting strong anti-gastritis and anti-inflammatory activities (Jeong et al, 2014), since we failed to identify these compounds in Pa-ME ( Fig. 4A and data not shown).…”

Essential oil of Artemisia argyi suppresses inflammatory responses by inhibiting JAK/STATs activation

“…A. argyi is reported to possess multiple pharmacological activities including anti-inflammatory, antimicrobial, antiasthma, analgesic, antivirus, antioxidant, antitumor and immunomodulatory effects (Jiang et al, 2005;Ge et al, 2016;Huang et al, 2012;Bao et al, 2013;), most of which are contributed by the essential oil existing in A. argyi leaves. Though the anti-inflammatory activity of Artemisia genus has been studied intensively and several anti-inflammatory compounds were also found in this plant (Moscatelli et al, 2006;Min et al, 2009;Choi et al, 2013;Habib and Waheed, 2013;Jeong et al, 2014;Park et al, 2015;Zeng et al, 2014), there is no much substantial evidence supporting the anti-inflammatory property of this herbal medicine and the molecular targets for the effects still remain unclear, which limited its application into clinical practice. Therefore this study was aimed to evaluate the anti-inflammatory potential of the essential oil of A. argyi (AAEO), and investigate the underlying mechanisms by lipopolysaccharide (LPS)-stimulated murine macrophages and acute in vivo inflammatory model in mice.…”