Anti-inflammatory Actions of (+)-3′α-Angeloxy-4′-keto-3′,4′-dihydroseselin (Pd-Ib) against Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice

Mu, Huai Xue; Liu, Jing; Fatima, Sarwat; Lin, Cheng Yuan; Shi, Xiao Ke; Du, Bin; Xiao, Haitao; Fan, Bao Min; Bian, Zhaoxiang

doi:10.1021/acs.jnatprod.5b01071

Cited by 33 publications

(17 citation statements)

References 42 publications

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“…It is well known that the anti-inflammatory cytokine IL-10 is elevated in colitis patients [47,[82][83][84][85][86]] and our study mirrored this effect upon DSS exposure. Elevated levels of IL-10 could be interpreted as a compensatory mechanism to counteract the substantial inflammation in the colon.…”

Section: Discussionsupporting

confidence: 85%

Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms

Shastri

Shinde

Sohal

et al. 2020

IJMS

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Oxidative stress is a key player of the inflammatory cascade responsible for the initiation of ulcerative colitis (UC). Although the short chain quinone idebenone is considered a potent antioxidant and a mitochondrial electron donor, emerging evidence suggests that idebenone also displays anti-inflammatory activity. This study evaluated the impact of idebenone in the widely used dextran sodium sulphate (DSS)-induced mouse model of acute colitis. Acute colitis was induced in C57BL/6J mice via continuous exposure to 2.5% DSS over 7 days. Idebenone was co-administered orally at a dose of 200 mg/kg body weight. Idebenone significantly prevented body weight loss and improved the disease activity index (DAI), colon length, and histopathological score. Consistent with its reported antioxidant function, idebenone significantly reduced the colonic levels of malondialdehyde (MDA) and nitric oxide (NO), and increased the expression of the redox factor NAD(P)H (nicotinamide adenine dinucleotide phosphate) dehydrogenase quinone-1 (NQO-1) in DSS-exposed mice. Immunohistochemistry revealed a significantly increased expression of tight junction proteins, which protect and maintain paracellular intestinal permeability. In support of an anti-inflammatory activity, idebenone significantly attenuated the elevated levels of pro-inflammatory cytokines in colon tissue. These results suggest that idebenone could represent a promising therapeutic strategy to interfere with disease pathology in UC by simultaneously inducing antioxidative and anti-inflammatory pathways.

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Section: Discussionsupporting

confidence: 85%

Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms

Shastri

Shinde

Sohal

et al. 2020

IJMS

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“…Body weight, stool consistency and fecal blood were monitored daily from the first day of drug treatment. Disease activity index (DAI) was determined as described previously [ 49 , 50 ]. Briefly, the scores of body weight loss, stool consistency and stool blood were calculated based on standard parameters [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

“…Distal colons with 0.5~1 cm length were fixed in 4% paraformaldehyde for 12 h and embedded in paraffin. Colon sections were stained with hematoxylin/eosin and then subjected to blind analysis and scored as previously described [ 49 , 50 ].…”

Section: Methodsmentioning

confidence: 99%

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

Zhao

Xiao

et al. 2017

Molecules

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Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity. Moreover, colonic pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) induced by colitis were dramatically decreased by magnolol. To further unveil the metabolic signatures upon magnolol treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in mice serum were performed. Compared with controls, abnormality of serum metabolic phenotypes in DSS-treated mice were effectively reversed by different doses of magnolol. In particular, magnolol treatment effectively elevated the serum levels of tryptophan metabolites including kynurenic acid (KA), 5-hydroxyindoleacetic acid, indoleacetic acid (IAA), indolelactic acid and indoxylsulfuric acid, which are potential aryl hydrocarbon receptor (AHR) ligands to impact colitis. These findings suggest that magnolol exerts anti-inflammatory effect on DSS-induced colitis and its underlying mechanisms are associated with the restoring of tryptophan metabolites that inhibit the colonic inflammation.

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“…Chai Hu Shu Gan San is composed of 3 key herbs: Chai Hu ( Bupleurum Chinese ), Xiangfu ( Cyperus rotundus ),and Chuanxiong ( Ligusticum chuanxiong ). Bupleurum Chinese iswell known for its anti-inflammatory actions [ 49 ] and neuroprotective effects [ 50 ]. It has also been explored extensively for antioxidant, anticancer, and apoptotic properties in treating other diseases [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials

Sun

Zhang

et al. 2018

BMC Complement Altern Med

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BackgroundDepression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression.MethodsSeveral databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017. In this review, wehave included randomized control trials that compared Chai Hu Shu Gan San (or its combination with a regular Western medicine) with a regular Western medicine alone for the treatment of depression. Two investigators independently extracted and analyzed the data using RevMan 5.2.0 software. Mean difference (with a 95% confidence interval) was used as efficacy indices for outcomes.ResultsWe included 42 studies involving 3234 patients with depression in 15 different types of diseases. Meta analyses showed better effect of Chai Hu Shu Gan San than fluoxetine for pure depression (MD = − 1.59, from − 2.82 to − 0.37, 4 trials, I2 = 26%), for post-stroke depression (MD = − 4.20, from − 6.20 to − 2.19, 7 trials, I2 = 96%), and for postpartum depression (MD = − 4.10, from − 7.48 to − 0.72 7 trials, I2 = 86%). None of the articles reported severe adverse events of oral administration of Chai Hu Shu Gan San. Furthermore, any adverse effects of using Chai Hu Shu Gan San alone were fewer than those of regular Western medicines.ConclusionsThis review found that Chai Hu Shu Gan San has some advantages in treating depression, especially post-stroke depression and post-partum depression. A meticulously designed and conducted randomized control trial is needed for further evaluation.

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Anti-inflammatory Actions of (+)-3′α-Angeloxy-4′-keto-3′,4′-dihydroseselin (Pd-Ib) against Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice

Cited by 33 publications

References 42 publications

Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms

Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials

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