Anti-inflammatory action of dapsone: inhibition of neutrophil adherence is associated with inhibition of chemoattractant-induced signal transduction

Debol, Steven M.; Herron, Michael J.; Nelson, Robert D.

doi:10.1002/jlb.62.6.827

Cited by 111 publications

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“…Several other mechanisms regarding dapsone's anti-inflammatory properties have been previously proposed. These include its propensity to interfere with neutrophil chemotactic migration [36,37] , integrin-mediated adherence [38] , leukocyte myeloperoxidase (MPO) and eosinophil peroxidase (EPO) activity [39][40][41] , leukotriene B 4 (LTB 4 ) stimulated inflammation and chemotactic response [42] , 5-lipoxygenase (5-LOX) metabolite production [43] , and the inhibition of lysosomal enzymes [44,45] . Perhaps the combination of dapsone's various antiinflammatory mechanisms, which mainly target the effector mechanisms of the inflammatory process, may lead to its efficacy in treating a variety of inflammatory dermatoses.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Dapsone in the Treatment of Pemphigus Vulgaris: A Single-Center Case Study

Baum¹,

Debby²,

Gilboa³

et al. 2016

Dermatology

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Background: Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease. Most patients require long-term therapy with systemic steroids, and a steroid-sparing agent is usually also utilized. Dapsone is a chemotherapeutic agent with anti-inflammatory properties that is used as a steroid-sparing agent in PV. Objective: The aim of the present study was to evaluate the efficacy of dapsone as an adjuvant therapy in patients with PV. Methods: A retrospective analysis of patients' files was performed. All 26 patients included in the study group were treated with dapsone as an adjuvant to systemic steroids for at least 3 consecutive months and were followed up during their dapsone treatment period. Results: After 3 months of treatment with dapsone, 13 patients were in the consolidation phase, 4 patients demonstrated partial remission on minimal therapy, 7 patients demonstrated complete remission on minimal therapy, and 2 patients were defined as treatment failures. The trend of clinical improvement continued after 6 months of treatment and at the study end point. Conclusion: This retrospective case series, one of the largest reported, indicates that dapsone is efficacious and safe for patients with PV in whom it is well tolerated soon after the initiation of treatment.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Dapsone in the Treatment of Pemphigus Vulgaris: A Single-Center Case Study

Baum¹,

Debby²,

Gilboa³

et al. 2016

Dermatology

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“…Dapsone has multiple anti-inflammatory properties. [1314] Although a topical formulation of dapsone (Aczone, Allergan, Inc., Irvine, CA, USA) has been approved by the FDA for the treatment of acne vulgaris but the risks of serious side effects have made it an undesirable drug for use in the relatively healthy acne population. [8] In our study, there is no significant difference between before and after hemoglobin level.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of 5% dapsone gel plus oral isotretinoin versus oral isotretinoin alone in acne vulgaris: A randomized double-blind study

et al. 2014

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Background:Acne vulgaris, a common human skin condition, is an inflammatory disease characterized by comedones, papules, nodules and possibly scarring.This study aimed to evaluate the efficacy of a combination of 5% dapsone gel plus oral isotretinoin in the treatment of acne vulgaris.Materials and Methods:A randomized, placebo-controlled, study was carried out on patients with moderate to severe acne. The patients were randomly divided in two groups: (dapsone gel and vehicle gel). All Patients were administered oral isotretinoin 20 mg daily and topical gel twice a day for 8 weeks. The Global Acne Assessment Score (GAAS), the number lesions and side-effects were documented at base line and weeks 4, 8 and 12.Results:A total of 58 patients (age range: 18-25 years) were included in our study. The number of lesions was significantly lower in the dapsone-treated group at all follow-up visits (P < 0.001). The mean GAAS score in the dapsone-treated group and in the Placebo-treated group decreased, but there was no statistical difference in two groups (P < 0.001). The side-effects on the dapsone-treated group were a mild burning sensation in 7 patients (24.13%), mild erythema of the skin and mild dryness in 4 (13.79%) and 3 (10.34%) cases respectively (P < 0.001). In our study, adverse effects were common but they were minor and tolerable. No clinically significant changes in laboratory parameters were observed (P < 0.001).Conclusions:Dapsone gel was an effective medication for patients who received isotretinoin for acne vulgaris treatment resulting in a significant reduction of the number of lesions.

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“…The skin lesions are characterized by patches of small, itchy blisters, usually found on the arms and back. 14 , 15 Dapsone as also been shown to suppress neutrophil migration by blocking integrin-mediated adherence function. 4 For neutrophils to be directed to an extravascular lesion, they must first adhere to vascular endothelial and then penetrate the vessel wall.…”

Section: Discussionmentioning

confidence: 99%

The Management of Oral Pemphigus Vulgaris with Systemic Corticosteroid and Dapsone

Azizi

Lawaf²

2008

Journal of Dental Research

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Anti-inflammatory action of dapsone: inhibition of neutrophil adherence is associated with inhibition of chemoattractant-induced signal transduction

Abstract: Abstract

Cited by 111 publications

References 0 publications

Efficacy of Dapsone in the Treatment of Pemphigus Vulgaris: A Single-Center Case Study

Efficacy of Dapsone in the Treatment of Pemphigus Vulgaris: A Single-Center Case Study

The efficacy of 5% dapsone gel plus oral isotretinoin versus oral isotretinoin alone in acne vulgaris: A randomized double-blind study

The Management of Oral Pemphigus Vulgaris with Systemic Corticosteroid and Dapsone

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