Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis

Meva, François Eya’ane; Prior, Timothy J.; Evans, David; Shah, Sachin N.; Tamngwa, Cynthia Fake; Belengue, Herschelle Guyenne Lagrange; Mang, Roland Emmanuel; Munro, Justin T.; Qahash, Tarrick; Llinás, Manuel

doi:10.1007/s11164-021-04607-3

Cited by 9 publications

(6 citation statements)

References 37 publications

(32 reference statements)

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“…Among these, nitrogen heterocycles, their analogs and derivatives are the most abundant. Derivatization and hybrid drug design along with transposition are some of the excellent tools to minimize the manufacturing-cost involved and to enhance drug development to counter resistance ( Aly et al, 2020 ; Eya’ane Meva et al, 2021 ; Kumar et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

et al. 2022

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Fluorinated heterocycles have attracted extensive attention not only in organic synthesis but also in pharmaceutical and medicinal sciences due to their enhanced biological activities than their non-fluorinated counterparts. Triazole is a simple five-membered heterocycle with three nitrogen atoms found in both natural and synthetic molecules that impart a broad spectrum of biological properties including but not limited to anticancer, antiproliferative, inhibitory, antiviral, antibacterial, antifungal, antiallergic, and antioxidant properties. In addition, incorporation of fluorine into triazole and its derivatives has been reported to enhance their pharmacological activity, making them promising drug candidates. This mini-review explores the current developments of backbone-fluorinated triazoles and functionalized fluorinated triazoles with established biological activities and pharmacological properties.

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Section: Introductionmentioning

confidence: 99%

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

et al. 2022

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“…Meva and co-workers reported 5-pyridin-2-y1-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester (64, Figure 20) acting as an antimalarial agent against Pf3D7 with IC 50 of 176 μM. [87] Additionally, they also reported its anti-inflammatory potential through the denaturation of egg albumin. Fernanda et al have analyzed the anti-malarial potential of 1,2,3-triazoles.…”

Section: Triazolementioning

confidence: 99%

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

Dhameliya,

Patel,

Kathuria

et al. 2024

ChemistrySelect

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Malaria remains a severe infectious disease caused by Plasmodium parasites among the primarily afflicting impoverished populations. According to World Health Organization (WHO) report, there were an estimated 247 million malarial cases globally, resulting in approximately 6,19,000 fatalities. Particularly prevalent in tropical and subtropical regions, the development of drug resistance has exacerbated this public health challenge. Consequently, there has been a concrete effort to explore novel compounds with anti‐malarial properties. In continuation of our previous works, this review focuses on heterocyclic compounds documented in 2021 and 2022, including artemisinin, benzimidazole, benzofuran, β‐lactam, coumarin, furan, indole, morpholine, piperazine, pyrimidine, quinoline, triazole, etc. highlighting their efficacy, structural characteristics, in vitro and in vivo activities, among other relevant aspects for the broad interest of medicinal chemists working on the design and development of novel anti‐malarial agents.

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“…Triazoles as important compounds with anti-inflammatory, 2 antimicrobial, 3 antimalarial, 4 antiviral, 5 and anticancer 6 activities can be synthesized through the click reaction between azides and alkynes catalyzed by copper. There have been several reports about copper catalysts used in the click reaction of alkynes and azides over the last few years.…”

Section: Introductionmentioning

confidence: 99%

Copper supported modified magnetic carrageenan as a bio-based catalyst for the synthesis of novel scaffolds bearing the 1,2,3-triazole unit through the click reaction

Khaleghi,

Esmkhani,

Noori

et al. 2024

Nanoscale Adv.

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Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1,2,4]triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis

Cited by 9 publications

References 37 publications

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

Copper supported modified magnetic carrageenan as a bio-based catalyst for the synthesis of novel scaffolds bearing the 1,2,3-triazole unit through the click reaction

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