Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial

Iorio‐Siciliano, Vincenzo; Blasi, A; Stratul, Ştefan‐Ioan; Ramaglia, Luca; Sculean, Anton; Salvi, Giovanni E.; Rusu, Darian

doi:10.1007/s00784-019-03060-2

Cited by 26 publications

(38 citation statements)

References 27 publications

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“…Non-surgical treatment of peri-implant mucositis: • Alternative measures for biofilm removal (4 RCTs [23][24][25][26]); • Adjunctive diode laser/antimicrobial photodynamic therapy (aPDT) (4 RCTs (5 publications) [27][28][29][30][31]); • Adjunctive local antiseptics (4 RCTs [32][33][34][35]); • Adjunctive systemic antibiotics (2 RCTs [29,36]); • Adjunctive probiotics (2 RCTs [37,38]); • Adjunctive antiseptic home care mouthrinse ).…”

Section: Subdivision Of Selected Studiesmentioning

confidence: 99%

“…As an adjunct to mechanical debridement, included studies employed either applications of CHX (0.12%) gel [32], a full-mouth disinfection concept utilizing CHX gel and mouth rinse [33,34], or applications of sodium hypochlorite [35]. Over a 3-to 6-month follow-up period, adjunctive use of the aforementioned local antimicrobials led to similar changes in BOP scores [32,34,35] and PD values [33][34][35] compared to control treatments (i.e., mechanical debridement alone), whereas one study reported on a greater PD reduction following the adjunctive use of local CHX (0.12%) applications [32].…”

Section: Adjunctive Local Antisepticsmentioning

confidence: 99%

“…Based on 4 RCTs, the WMD in PD values was − 0.23 mm [SE = 0.10; p = 0.03; 95% CI (− 0.43, − 0.03); unit of analysis: implant], favoring the adjunctive use of local antiseptics (i.e., CHX and sodium hypochlorite; p value for heterogeneity: 0.929, I 2 = 0.0% = low heterogeneity; Fig. 2f ) [32][33][34][35].…”

Section: Adjunctive Local Antisepticsmentioning

confidence: 99%

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Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

2021

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Purpose To evaluate the efficacy of alternative or adjunctive measures to conventional non-surgical or surgical treatment of peri-implant mucositis and peri-implantitis. Material and methods Prospective randomized and nonrandomized controlled studies comparing alternative or adjunctive measures, and reporting on changes in bleeding scores (i.e., bleed0ing index (BI) or bleeding on probing (BOP)), probing depth (PD) values or suppuration (SUPP) were searched. Results Peri-implant mucositis: adjunctive use of local antiseptics lead to greater PD reduction (weighted mean difference (WMD) = − 0.23 mm; p = 0.03, respectively), whereas changes in BOP were comparable (WMD = − 5.30%; p = 0.29). Non-surgical treatment of peri-implantitis: alternative measures for biofilm removal and systemic antibiotics yielded higher BOP reduction (WMD = − 28.09%; p = 0.01 and WMD = − 17.35%; p = 0.01, respectively). Surgical non-reconstructive peri-implantitis treatment: WMD in PD amounted to − 1.11 mm favoring adjunctive implantoplasty (p = 0.02). Adjunctive reconstructive measures lead to significantly higher radiographic bone defect fill/reduction (WMD = 56.46%; p = 0.01 and WMD = − 1.47 mm; p = 0.01), PD (− 0.51 mm; p = 0.01) and lower soft-tissue recession (WMD = − 0.63 mm; p = 0.01), while changes in BOP were not significant (WMD = − 11.11%; p = 0.11). Conclusions Alternative and adjunctive measures provided no beneficial effect in resolving peri-implant mucositis, while alternative measures were superior in reducing BOP values following non-surgical treatment of peri-implantitis. Adjunctive reconstructive measures were beneficial regarding radiographic bone-defect fill/reduction, PD reduction and lower soft-tissue recession, although they did not improve the resolution of mucosal inflammation.

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Section: Subdivision Of Selected Studiesmentioning

confidence: 99%

Section: Adjunctive Local Antisepticsmentioning

confidence: 99%

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Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

2021

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“…Also found that 0.5% cetylpyridinium chloride and 40% citric acid were not effective in reducing biofilm. Lorio-Siciliano et al [21] used sodium hypochlorite as an adjunct to mechanical debridement and compared with mechanical debridement alone (ultrasonic scaler). A 5× application for 30 s of NaOCl gel prior to mechanical debridement with an ultrasonic scaler failed to statistically significantly improve PD and BoP reductions compared with mechanical debridement alone.…”

Section: Treatment Modalities For Peri-implant Diseases Treatment Therapies For Peri-implant Mucositismentioning

confidence: 99%

Periimplant diseases and its treatment modalities: A review

Shah¹,

Shetty²,

Dharmadhikari³

2021

Int. J. Appl. Dent. Sci.

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Dental implants are widely used and are considered to be one of the most feasible treatment options that can be used to replace missing teeth. The placement of dental implants has become a routine procedure in the oral rehabilitation of totally or partially edentulous patient. Implant treatment effectively restores normal oral function and esthetics and has overall satisfactory survival rates. However, implant therapy has certain drawbacks and risks, such as inflammation of peri-implant soft and hard tissues. This review article will provide insights regarding different treatment modalities for treating peri-implant diseases.

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“…An amino acid buffered hypochlorite solution (Perisolv® De Ore biomaterials Negrar -Verona Italy) has been previously used for non-surgical periodontal and peri-implant therapy for the surface treatment of involved teeth and implants [11][12][13][14]. The product is a system with two components: sodium hypochlorite solution (NaOCl) at 0.95% and gel containing amino acids (glutamic acid, leucine, lysine), carboxymethylcellulose, and ultrapure water (pH > 10).…”

Section: Introductionmentioning

confidence: 99%

Effects of an amino acid buffered hypochlorite solution as an adjunctive to air-powder abrasion in open-flap surface decontamination of implants failed for peri-implantitis: an ex vivo randomized clinical trial

Monaca

Mengoni²,

Puggioni

et al. 2022

Clin Oral Invest

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Objectives To evaluate ex vivo the efficacy of an amino acid buffered hypochlorite solution supplemented to surface debridement with air-powder abrasion in removing bacterial biofilm following open-flap decontamination of implants failed due to peri-implantitis. Materials and methods This study was an ex vivo, single-blind, randomized, intra-subject investigation. Study population consisted of 20 subjects with at least three implants failed for peri-implantitis (in function for > 12 months and progressive bone loss exceeding 50%) to be explanted. For each patient, implants were randomly assigned to surface decontamination with sodium bicarbonate air-powder abrasion (test-group 1) or sodium bicarbonate air-powder abrasion supplemented by amino acid buffered hypochlorite solution (test-group 2) or untreated control group. Following open-flap surgery, untreated implants (control group) were explanted. Afterwards, test implants were decontaminated according to allocation and explanted. Microbiological analysis was expressed in colony-forming units (CFU/ml). Results A statistically significant difference in the concentrations of CFU/ml was found between implants of test-group 1 (63,018.18 ± 228,599.36) (p = 0.007) and implants of test-group 2 (260.00 ± 375.80) (p < 0.001) compared to untreated implants (control group) (86,846.15 ± 266,689.44). The concentration of CFU/ml on implant surfaces was lower in test-group 2 than in test-group 1, with a statistically significant difference (p < 0.001). Conclusion The additional application of amino acid buffered hypochlorite solution seemed to improve the effectiveness of implant surface decontamination with air-powder abrasion following open-flap surgery. Clinical relevance. Lacking evidence on the most effective method for biofilm removal from contaminated implant surfaces, the present experimental study provides further information for clinicians and researchers.

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Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial

Cited by 26 publications

References 27 publications

Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

Periimplant diseases and its treatment modalities: A review

Effects of an amino acid buffered hypochlorite solution as an adjunctive to air-powder abrasion in open-flap surface decontamination of implants failed for peri-implantitis: an ex vivo randomized clinical trial

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